Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate.

scientific article

Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/BI0524666
P698PubMed publication ID16906772

P50authorHans-Joachim LehmlerQ37369137
Gabriele LudewigQ48356974
Neil OsheroffQ88626020
P2093author name stringLarry W Robertson
Ryan P Bender
P433issue33
P407language of work or nameEnglishQ1860
P921main subjectpoisoningQ114953
polychlorinated biphenylQ211171
P304page(s)10140-10152
P577publication date2006-08-01
P1433published inBiochemistryQ764876
P1476titlePolychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate.
P478volume45

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cites work (P2860)
Q24627296(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases
Q35788447Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions
Q24627367Bioflavonoids as poisons of human topoisomerase II alpha and II beta
Q58616150Bioflavonoids promote stable translocations between MLL-AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks
Q34379629Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism
Q37355255Chlorinated biphenyl quinones and phenyl-2,5-benzoquinone differentially modify the catalytic activity of human hydroxysteroid sulfotransferase hSULT2A1.
Q35510474Crystal structure and density functional theory studies of toxic quinone metabolites of polychlorinated biphenyls.
Q36903197DNA topoisomerase II, genotoxicity, and cancer
Q36160055Density functional theory study of semiquinone radical anions of polychlorinated biphenyls in the syn- and anti-like conformation
Q24642324Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement
Q35679872Effects of Olive Metabolites on DNA Cleavage Mediated by Human Type II Topoisomerases
Q37064199Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases
Q39939254Etoposide quinone is a covalent poison of human topoisomerase IIβ.
Q35058862Etoposide quinone is a redox-dependent topoisomerase II poison
Q28392095Identification of sulfated metabolites of 4-chlorobiphenyl (PCB3) in the serum and urine of male rats
Q28396295Investigation of mechanism(s) of DNA damage induced by 4-monochlorobiphenyl (PCB3) metabolites
Q33889361Leishmania actin binds and nicks kDNA as well as inhibits decatenation activity of type II topoisomerase
Q34686946Mechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin F
Q27004214Metabolism and metabolites of polychlorinated biphenyls
Q33944673Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate
Q33662233Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIα
Q49459452Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα.
Q36520921Oxidative metabolites of curcumin poison human type II topoisomerases
Q37658182Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons
Q36828366Polychlorinated biphenyls (PCBs) as initiating agents in hepatocellular carcinoma
Q36127147Probing conformational changes in human DNA topoisomerase IIα by pulsed alkylation mass spectrometry
Q33957966Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.
Q35002075Recognition and repair of chemically heterogeneous structures at DNA ends
Q62609188Repair of DNA damage induced by the mycotoxin alternariol involves tyrosyl-DNA phosphodiesterase 1
Q37108461The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing
Q53231599The genotoxic and antigenotoxic effects of tannic acid in human lymphocytes.
Q36620880The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action.
Q37652882Topoisomerase II and leukemia
Q33350077Topoisomerase II inhibition involves characteristic chromosomal expression patterns

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