Defensins from insects and plants interact with fungal glucosylceramides

scientific article published on 6 November 2003

Defensins from insects and plants interact with fungal glucosylceramides is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M311165200
P698PubMed publication ID14604982

P50authorKarin ThevissenQ38319981
Bart P H J ThommaQ87722870
Bruno P A CammueQ88085635
P2093author name stringMartina Leipelt
Claudia Ott
Ernst Heinz
Ulrich Zähringer
Isabelle E J A François
Kathelijne K A Ferket
Dirk C Warnecke
P2860cites workSolution structures of the antifungal heliomicin and a selected variant with both antibacterial and antifungal activitiesQ27635109
Refined three-dimensional solution structure of insect defensin AQ27729857
Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeastQ27932650
A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii).Q27934644
Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) geneQ27939850
Identification and characterization of a sphingolipid delta 4-desaturase familyQ28506937
Two-dimensional 1H NMR study of recombinant insect defensin A in water: resonance assignments, secondary structure and global foldingQ30856449
Interaction of the verotoxin 1B subunit with soluble aminodeoxy analogues of globotriaosyl ceramidesQ33343700
Induction of verotoxin sensitivity in receptor-deficient cell lines using the receptor glycolipid globotriosylceramideQ33837961
Electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of the lipid molecular species composition of yeast subcellular membranes reveals acyl chain-based sorting/remodeling of distinct molecular species en route to the plasma membraneQ33871942
Plant defensins.Q34160569
Recently discovered functions of glucosylceramides in plants and fungiQ35162993
Human antibodies against a purified glucosylceramide from Cryptococcus neoformans inhibit cell budding and fungal growthQ39517451
CD40 ligand, Bcl-2, and Bcl-xL spare group I Burkitt lymphoma cells from CD77-directed killing via Verotoxin-1 B chain but fail to protect against the holotoxinQ40847307
Endocytosis from coated pits of Shiga toxin: a glycolipid-binding protein from Shigella dysenteriae 1.Q41575546
Insect immunity. Isolation from the lepidopteran Heliothis virescens of a novel insect defensin with potent antifungal activityQ42058984
The ATPase domain of hsp70 possesses a unique binding specificity for 3'-sulfogalactolipidsQ42635324
Characterization of monoclonal antibody MEST-2 specific to glucosylceramide of fungi and plantsQ43565267
Characterization of cerebrosides from the thermally dimorphic mycopathogen Histoplasma capsulatum: expression of 2-hydroxy fatty N-acyl (E)-Delta(3)-unsaturation correlates with the yeast-mycelium phase transitionQ43565271
Sterol glycosides and cerebrosides accumulate in Pichia pastoris, Rhynchosporium secalis and other fungi under normal conditions or under heat shock and ethanol stressQ43621887
Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts). Comparison of cholesterol to plant, fungal, and disease-associated sterols and comparison of sphingomyelin, cerebrosides, aQ43658464
The aglycone of sulfogalactolipids can alter the sulfate ester substitution position required for hsc70 recognitionQ43745061
Characterization of glucosylceramides in Pseudallescheria boydii and their involvement in fungal differentiationQ44013135
DmAMP1, an antifungal plant defensin from dahlia (Dahlia merckii), interacts with sphingolipids from Saccharomyces cerevisiaeQ44586191
Primary structure and inhibition of protein synthesis in eukaryotic cell-free system of a novel thionin, gamma-hordothionin, from barley endospermQ44759281
A sphingolipid desaturase from higher plants. Identification of a new cytochrome b5 fusion proteinQ48014345
Glucosylceramide synthases, a gene family responsible for the biosynthesis of glucosphingolipids in animals, plants, and fungiQ48354725
Specific binding sites for an antifungal plant defensin from Dahlia (Dahlia merckii) on fungal cells are required for antifungal activity.Q54064016
Primary structure of omega-hordothionin, a member of a novel family of thionins from barley endosperm, and its inhibition of protein synthesis in eukaryotic and prokaryotic cell-free systems.Q54398451
Globotriaosyl ceramide (CD77/Gb3) in the glycolipid-enriched membrane domain participates in B-cell receptor–mediated apoptosis by regulating Lyn kinase activity in human B cellsQ57363943
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)3900-3905
P577publication date2003-11-06
P1433published inJournal of Biological ChemistryQ867727
P1476titleDefensins from insects and plants interact with fungal glucosylceramides
P478volume279

Reverse relations

cites work (P2860)
Q34538329A Family of CSαβ Defensins and Defensin-Like Peptides from the Migratory Locust, Locusta migratoria, and Their Expression Dynamics during Mycosis and Nosemosis
Q33747075A genomic approach highlights common and diverse effects and determinants of susceptibility on the yeast Saccharomyces cerevisiae exposed to distinct antimicrobial peptides
Q45025652A non-cyclic baboon θ-defensin derivative exhibiting antimicrobial activity against the phytopathogen Verticillium dahliae.
Q91718483A novel recombinant javanicin with dual antifungal and anti-proliferative activities
Q41541798ARACINs, Brassicaceae-specific peptides exhibiting antifungal activities against necrotrophic pathogens in Arabidopsis
Q38187883Activation of stress signalling pathways enhances tolerance of fungi to chemical fungicides and antifungal proteins
Q36195040Advances on plant products with potential to control toxigenic fungi: a review
Q33211603Altered fungal sensitivity to a plant antimicrobial peptide through over-expression of yeast cDNAs
Q37880638Antibiotic activities of host defense peptides: more to it than lipid bilayer perturbation.
Q46969762Antifungal activity of plant defensin AFP1 in Brassica juncea involves the recognition of the methyl residue in glucosylceramide of target pathogen Candida albicans
Q40821099Antifungal mechanisms of a plant defensin MtDef4 are not conserved between the ascomycete fungi Neurospora crassa and Fusarium graminearum
Q38740360Antifungal plant defensins: increased insight in their mode of action as a basis for their use to combat fungal infections
Q26998006Antifungal plant defensins: mechanisms of action and production
Q38081821Antifungal proteins: More than antimicrobials?
Q58030986Antimicrobial Peptides
Q28082004Antimicrobial Peptides from Plants
Q46071524Antimicrobial activity of broccoli (Brassica oleracea var. italica) cultivar Avenger against pathogenic bacteria, phytopathogenic filamentous fungi and yeast
Q37918722Antimicrobial peptides: modes of mechanism, modulation of defense responses
Q38089201Antimicrobial peptides: to membranes and beyond
Q37936568Apoptosis-inducing antifungal peptides and proteins.
Q61052908Arabidopsis thaliana plants expressing human beta-defensin-2 are more resistant to fungal attack: functional homology between plant and human defensins
Q37323050Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin-lipid oligomeric assemblies and membrane permeabilization
Q37398912Biochemical characterization of potential virulence markers in the human fungal pathogen Pseudallescheria boydii
Q36889096Biology and pathogenesis of Fonsecaea pedrosoi, the major etiologic agent of chromoblastomycosis
Q36095320Biosynthesis and immunogenicity of glucosylceramide in Cryptococcus neoformans and other human pathogens
Q92504639Biosynthesis of long chain base in sphingolipids in animals, plants and fungi
Q33270640Cellular processes and pathways that protect Saccharomyces cerevisiae cells against the plasma membrane-perturbing compound chitosan
Q64970741CgGCS, Encoding a Glucosylceramide Synthase, Is Required for Growth, Conidiation and Pathogenicity in Colletotrichum gloeosporioides.
Q89965306Characterization, Expression Profiling, and Functional Analysis of PtDef, a Defensin-Encoding Gene From Populus trichocarpa
Q89562790Class I defensins (BraDef) from broccoli (Brassica oleracea var. italica) seeds and their antimicrobial activity
Q46379732Co-overexpression of Brassica juncea NPR1 (BjNPR1) and Trigonella foenum-graecum defensin (Tfgd) in transgenic peanut provides comprehensive but varied protection against Aspergillus flavus and Cercospora arachidicola
Q33895042Control of glucosylceramide production and morphogenesis by the Bar1 ceramide synthase in Fusarium graminearum
Q38936327Convergent evolution of defensin sequence, structure and function
Q35821584Deciphering the mode of action of a mutant Allium sativum Leaf Agglutinin (mASAL), a potent antifungal protein on Rhizoctonia solani.
Q38201011Defensins: antifungal lessons from eukaryotes
Q45010416Differential antifungal and calcium channel-blocking activity among structurally related plant defensins
Q34301662Distinct antifungal mechanisms: beta-defensins require Candida albicans Ssa1 protein, while Trk1p mediates activity of cysteine-free cationic peptides
Q27667797Disulfide-stabilized Helical Hairpin Structure and Activity of a Novel Antifungal Peptide EcAMP1 from Seeds of Barnyard Grass (Echinochloa crus-galli)
Q44586191DmAMP1, an antifungal plant defensin from dahlia (Dahlia merckii), interacts with sphingolipids from Saccharomyces cerevisiae
Q57134484Ectopic expression of Dahlia merckii defensin DmAMP1 improves papaya resistance to Phytophthora palmivora by reducing pathogen vigor
Q27312540Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death
Q44364474Evolutionary relationship between defensins in the Poaceae family strengthened by the characterization of new sugarcane defensins.
Q84428282Expression of a plant defensin in rice confers resistance to fungal phytopathogens
Q54390214Expression of a radish defensin in transgenic wheat confers increased resistance to Fusarium graminearum and Rhizoctonia cerealis.
Q34059812Four plant defensins from an indigenous South African Brassicaceae species display divergent activities against two test pathogens despite high sequence similarity in the encoding genes
Q42713687Functional characterization of the Aspergillus nidulans glucosylceramide pathway reveals that LCB Δ8-desaturation and C9-methylation are relevant to filamentous growth, lipid raft localization and Psd1 defensin activity
Q35136990Functional expression and activity of the recombinant antifungal defensin PvD1r from Phaseolus vulgaris L. (common bean) seeds
Q38703594Fungal Glucosylceramide-Specific Camelid Single Domain Antibodies Are Characterized by Broad Spectrum Antifungal Activity.
Q37949339Fungal glucosylceramides: from structural components to biologically active targets of new antimicrobials
Q34628045Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans
Q46972707Glucosylceramide synthase is essential for alfalfa defensin-mediated growth inhibition but not for pathogenicity of Fusarium graminearum.
Q36612983Glucosylceramides are critical for cell-type differentiation and organogenesis, but not for cell viability in Arabidopsis
Q35234280Glucosylceramides are required for mycelial growth and full virulence in Penicillium digitatum
Q47970288Glucosylceramides in Colletotrichum gloeosporioides are involved in the differentiation of conidia into mycelial cells
Q36643254Hidden weapons of microbial destruction in plant genomes
Q37845727Host defense peptides: general overview and an update on their activity against Chlamydia spp.
Q40433088Human beta-defensins: differential activity against candidal species and regulation by Candida albicans
Q33382327Identification and functional characterization of the 2-hydroxy fatty N-acyl-Delta3(E)-desaturase from Fusarium graminearum
Q34729481Identification and mechanism of action of the plant defensin NaD1 as a new member of the antifungal drug arsenal against Candida albicans
Q34433506Identification of defensin-encoding genes of Picea glauca: characterization of PgD5, a conserved spruce defensin with strong antifungal activity.
Q46843737Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling
Q41387320In vitro activity of the antifungal plant defensin RsAFP2 against Candida isolates and its in vivo efficacy in prophylactic murine models of candidiasis
Q52837540Increased resistance to late leaf spot disease in transgenic peanut using a combination of PR genes.
Q51363895Insect antimicrobial peptides show potentiating functional interactions against Gram-negative bacteria.
Q41810959Insight into invertebrate defensin mechanism of action: oyster defensins inhibit peptidoglycan biosynthesis by binding to lipid II.
Q37909413Killer peptide: a novel paradigm of antimicrobial, antiviral and immunomodulatory auto-delivering drugs.
Q41515503Killing of staphylococci by θ-defensins involves membrane impairment and activation of autolytic enzymes
Q33235964Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast
Q37482149Lipid signalling in pathogenic fungi
Q64054800Membrane Sphingolipids Regulate the Fitness and Antifungal Protein Susceptibility of
Q36313467Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection
Q88979031Monohexosylceramides from Rhizopus Species Isolated from Brazilian Caatinga: Chemical Characterization and Evaluation of Their Anti-Biofilm and Antibacterial Activities
Q44694854Nematode-derived drosomycin-type antifungal peptides provide evidence for plant-to-ecdysozoan horizontal transfer of a disease resistance gene
Q45226880Neutral glycolipids of the filamentous fungus Neurospora crassa: altered expression in plant defensin-resistant mutants
Q38752970Nicotiana alata Defensin Chimeras Reveal Differences in the Mechanism of Fungal and Tumor Cell Killing and an Enhanced Antifungal Variant
Q38072770Peptide antimicrobials: cell wall as a bacterial target
Q46466589Phaseococcin, an antifungal protein with antiproliferative and anti-HIV-1 reverse transcriptase activities from small scarlet runner beans
Q27682739Phosphoinositide-mediated oligomerization of a defensin induces cell lysis
Q38477825Plant antifungal proteins and their applications in agriculture
Q37677077Plant antimicrobial peptides.
Q37653904Plant defensins: defense, development and application.
Q91837486Plant defensins: types, mechanism of action and prospects of genetic engineering for enhanced disease resistance in plants
Q42278806Plants' Natural Products as Alternative Promising Anti-Candida Drugs.
Q38679057Plasma membrane lipids and their role in fungal virulence
Q58745624Primary Structure Analysis of Antifungal Peptides from Cultivated and Wild Cereals
Q38079168Properties and mechanisms of action of naturally occurring antifungal peptides
Q33780738Psd1 Effects on Candida albicans Planktonic Cells and Biofilms
Q45845010Psd1 binding affinity toward fungal membrane components as assessed by SPR: The role of glucosylceramide in fungal recognition and entry
Q64077248Purification of an Antifungal Peptide from Seeds of var. and Investigation of Its Antifungal Activity and Mechanism of Action
Q27649614Rational design of peptides active against the gram positive bacteria Staphylococcus aureus
Q60143650Recent Advances in the Use of Galleria mellonella Model to Study Immune Responses against Human Pathogens
Q53294820Recombinant expression, affinity purification and functional characterization of Scots pine defensin 1
Q55424061Regulated Cell Death as a Therapeutic Target for Novel Antifungal Peptides and Biologics.
Q26864737Revealing the properties of plant defensins through dynamics
Q90649119Rice Defensin OsAFP1 is a New Drug Candidate against Human Pathogenic Fungi
Q34300991Role of sphingolipids in microbial pathogenesis
Q27935700SKN1, a novel plant defensin-sensitivity gene in Saccharomyces cerevisiae, is implicated in sphingolipid biosynthesis
Q40221007Similarities between Reproductive and Immune Pistil Transcriptomes of Arabidopsis Species
Q91890020Species-Specific Differences in the Susceptibility of Fungi to the Antifungal Protein AFP Depend on C-3 Saturation of Glycosylceramides
Q37099376Sphingolipid C-9 methyltransferases are important for growth and virulence but not for sensitivity to antifungal plant defensins in Fusarium graminearum.
Q38833311Sphingolipids as targets for treatment of fungal infections
Q36994314Stress-induced cell death is mediated by ceramide synthesis in Neurospora crassa
Q34469047Structure, cellular distribution, antigenicity, and biological functions of Fonsecaea pedrosoi ceramide monohexosides
Q36209188Surveying the potential of secreted antimicrobial peptides to enhance plant disease resistance
Q34177095Symbiotic plant peptides eliminate Candida albicans both in vitro and in an epithelial infection model and inhibit the proliferation of immortalized human cells.
Q28547086Synergistic Activity of the Plant Defensin HsAFP1 and Caspofungin against Candida albicans Biofilms and Planktonic Cultures
Q35084966Synthesis and biological properties of fungal glucosylceramide
Q44711910Tandem combination of Trigonella foenum-graecum defensin (Tfgd2) and Raphanus sativus antifungal protein (RsAFP2) generates a more potent antifungal protein
Q47114771The Antifungal Plant Defensin HsAFP1 Is a Phosphatidic Acid-Interacting Peptide Inducing Membrane Permeabilization.
Q34047342The Antifungal Plant Defensin HsAFP1 from Heuchera sanguinea Induces Apoptosis in Candida albicans
Q37580398The C-terminal propeptide of a plant defensin confers cytoprotective and subcellular targeting functions
Q47301333The Defensins Consist of Two Independent, Convergent Protein Superfamilies
Q26798091The Plant Peptidome: An Expanding Repertoire of Structural Features and Biological Functions
Q35762592The antifungal plant defensin AhPDF1.1b is a beneficial factor involved in adaptive response to zinc overload when it is expressed in yeast cells.
Q37215786The antifungal plant defensin AtPDF2.3 from Arabidopsis thaliana blocks potassium channels.
Q45930644The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way in Candida albicans.
Q33621572The antifungal protein PAF interferes with PKC/MPK and cAMP/PKA signalling of Aspergillus nidulans.
Q57824019The peach (Prunus persica) defensin PpDFN1 displays antifungal activity through specific interactions with the membrane lipids
Q34183105The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans.
Q92015729The plant defensin gene AtPDF2.1 mediates ammonium metabolism by regulating glutamine synthetase activity in Arabidopsis thaliana
Q46702870The plant defensin, NaD1, enters the cytoplasm of Fusarium oxysporum hyphae
Q50092750The synthetic form of a novel chicken beta-defensin identified in silico is predominantly active against intestinal pathogens
Q90395922TmSpz4 Plays an Important Role in Regulating the Production of Antimicrobial Peptides in Response to Escherichia coli and Candida albicans Infections
Q27931025Transcriptional response of Saccharomyces cerevisiae to the plasma membrane-perturbing compound chitosan
Q33245396Transgenic expression of gallerimycin, a novel antifungal insect defensin from the greater wax moth Galleria mellonella, confers resistance to pathogenic fungi in tobacco
Q42507405Two mitogen-activated protein kinase signalling cascades mediate basal resistance to antifungal plant defensins in Fusarium graminearum.
Q79443415Use of a PTGS-MAR expression system for efficient in planta production of bioactive Arabidopsis thaliana plant defensins
Q59126012Variability of defensin genes from a Mexican endemic Triatominae: (Hemiptera: Reduviidae)
Q35641043Vesicular polysaccharide export in Cryptococcus neoformans is a eukaryotic solution to the problem of fungal trans-cell wall transport
Q33350056Vv-AMP1, a ripening induced peptide from Vitis vinifera shows strong antifungal activity
Q55312684X-ray structure of a carpet-like antimicrobial defensin-phospholipid membrane disruption complex.

Search more.