Biochemical Differences and Similarities between the DEAD-Box Helicase Orthologs DDX3X and Ded1p

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Biochemical Differences and Similarities between the DEAD-Box Helicase Orthologs DDX3X and Ded1p is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JMB.2017.10.008
P932PMC publication ID5693625
P698PubMed publication ID29037760

P2093author name stringDeepak Sharma
Eckhard Jankowsky
Andrea A Putnam
P2860cites workDEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAsQ24295198
DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth controlQ24296626
A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replicationQ24303621
The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational controlQ24309332
Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress responseQ24337086
DDX3, a potential target for cancer treatmentQ26779054
DEAD-box helicases as integrators of RNA, nucleotide and protein bindingQ26999638
RNA helicase proteins as chaperones and remodelersQ27025517
Coupling between the DEAD-box RNA helicases Ded1p and eIF4AQ27468894
Crystal structure of conserved domains 1 and 2 of the human DEAD-box helicase DDX3X in complex with the mononucleotide AMPQ27646741
Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structureQ27860806
Duplex unwinding with DEAD-box proteins.Q54687163
The DEAD-box protein Ded1 unwinds RNA duplexes by a mode distinct from translocating helicasesQ57259006
Biochemical and kinetic characterization of the RNA helicase activity of eukaryotic initiation factor 4AQ77353532
Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicaseQ27876214
The DEAD-box helicase Ded1 from yeast is an mRNP cap-associated protein that shuttles between the cytoplasm and nucleusQ27930711
ATP- and ADP-dependent modulation of RNA unwinding and strand annealing activities by the DEAD-box protein DED1.Q27933124
Requirement of the DEAD-Box protein ded1p for messenger RNA translationQ27935125
The DEAD-box protein Ded1 modulates translation by the formation and resolution of an eIF4F-mRNA complexQ27936899
The p20 and Ded1 proteins have antagonistic roles in eIF4E-dependent translation in Saccharomyces cerevisiae.Q27937737
The DEAD-box protein Dbp2 functions with the RNA-binding protein Yra1 to promote mRNP assemblyQ27938290
Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt SignalingQ29147391
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutationsQ30040534
The newly discovered Q motif of DEAD-box RNA helicases regulates RNA-binding and helicase activityQ34327481
DEAD-box proteins unwind duplexes by local strand separationQ34707215
Molecular insights into RNA and DNA helicase evolution from the determinants of specificity for a DEAD-box RNA helicaseQ35247331
Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysisQ35470624
Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A.Q35876068
DDX3 as a strongest prognosis marker and its downregulation promotes metastasis in colorectal cancerQ36210955
Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3.Q36518348
The DEAD-box helicase eIF4A: paradigm or the odd one out?Q36662305
Human DEAD box helicase 3 couples IκB kinase ε to interferon regulatory factor 3 activation.Q36826843
Human DDX3 protein is a valuable target to develop broad spectrum antiviral agentsQ36904981
DEAD-box proteins can completely separate an RNA duplex using a single ATP.Q37068571
Recruitment, Duplex Unwinding and Protein-Mediated Inhibition of the Dead-Box RNA Helicase Dbp2 at Actively Transcribed ChromatinQ37154644
Medulloblastoma-associated DDX3 variant selectively alters the translational response to stressQ37317515
The current understanding of Ded1p/DDX3 homologs from yeast to humanQ37357716
The prognostic effect of DDX3 upregulation in distant breast cancer metastases.Q37617548
From unwinding to clamping - the DEAD box RNA helicase familyQ37903659
Toward a molecular understanding of RNA remodeling by DEAD-box proteinsQ38045141
The Ded1/DDX3 subfamily of DEAD-box RNA helicasesQ38231370
RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity.Q38547052
RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3Q38734333
Prevalence and architecture of de novo mutations in developmental disordersQ38991782
RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.Q39754912
Division of Labor in an Oligomer of the DEAD-Box RNA Helicase Ded1pQ40694722
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphomaQ40717160
DEAD-box RNA helicase domains exhibit a continuum between complete functional independence and high thermodynamic coupling in nucleotide and RNA duplex recognitionQ42234194
AMP sensing by DEAD-box RNA helicasesQ42669947
Human DEAD-box ATPase DDX3 shows a relaxed nucleoside substrate specificityQ44216908
Low/negative expression of DDX3 might predict poor prognosis in non-smoker patients with oral cancerQ44724402
Characterization of the mammalian DEAD-box protein DDX5 reveals functional conservation with S. cerevisiae ortholog Dbp2 in transcriptional control and glucose metabolism.Q48273234
P4510describes a project that usesImageQuantQ112270642
P433issue23
P407language of work or nameEnglishQ1860
P304page(s)3730-3742
P577publication date2017-10-13
P1433published inJournal of Molecular BiologyQ925779
P1476titleBiochemical Differences and Similarities between the DEAD-Box Helicase Orthologs DDX3X and Ded1p
P478volume429

Reverse relations

cites work (P2860)
Q89896482DEAD-box RNA Helicase DDX3: Functional Properties and Development of DDX3 Inhibitors as Antiviral and Anticancer Drugs
Q64230099Mechanistic characterization of the DEAD-box RNA helicase Ded1 from yeast as revealed by a novel technique using single-molecule magnetic tweezers
Q92636216RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X
Q101226239Small molecules as potent biphasic modulators of protein liquid-liquid phase separation
Q97885504Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation
Q91841007The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X

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