RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X

scientific article published on 09 January 2020

RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/CELLS9010170
P932PMC publication ID7016805
P698PubMed publication ID31936642

P50authorDavid A JansQ62840108
Natalie A BorgQ45626069
Steven M. HeatonQ47503782
P2093author name stringSarah C Atkinson
Michelle D Audsley
Sundy N Y Yang
P2860cites workDDX3 DEAD-box RNA helicase is required for hepatitis C virus RNA replicationQ24293603
Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migrationQ24316451
Cellular cofactors affecting hepatitis C virus infection and replicationQ24317564
DEAD-box helicases as integrators of RNA, nucleotide and protein bindingQ26999638
Ring Expanded Nucleoside Analogues Inhibit RNA Helicase and Intracellular Human Immunodeficiency Virus Type 1 ReplicationQ27486874
Crystal structure of conserved domains 1 and 2 of the human DEAD-box helicase DDX3X in complex with the mononucleotide AMPQ27646741
Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation ModelingQ27860847
Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export functionQ28289911
An efficient, short synthesis and potent anti-hepatitis B viral activity of a novel ring-expanded purine nucleoside analogue containing a 5:7-fused, planar, aromatic, imidazo[4,5-e][1,3]diazepine ring systemQ28377459
Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?Q28486779
Antiviral drug resistance as an adaptive processQ33878407
The Thr205 phosphorylation site within respiratory syncytial virus matrix (M) protein modulates M oligomerization and virus productionQ33887779
Novel, Broad Spectrum Anti-Cancer Agents Containing the Tricyclic 5:7:5-Fused Diimidazodiazepine Ring SystemQ34975091
Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 HeterodimerQ63248526
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus InfectionQ91350840
The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3XQ91841007
Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysisQ35470624
Targeting DDX3 with a small molecule inhibitor for lung cancer therapyQ35822589
Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virusQ35893162
Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancerQ36414044
Human DDX3 protein is a valuable target to develop broad spectrum antiviral agentsQ36904981
The first synthesis of a novel 5:7:5-fused diimidazodiazepine ring system and some of its chemical propertiesQ37119311
The role of the DEAD-box RNA helicase DDX3 in mRNA metabolismQ38100770
RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3Q38734333
A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection.Q38987775
Cellular DDX3 regulates Japanese encephalitis virus replication by interacting with viral un-translated regionsQ39034822
Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosisQ40015254
c-Jun N-terminal kinase activity is required for efficient respiratory syncytial virus productionQ40382066
RNA helicase DDX3: a novel therapeutic target in Ewing sarcomaQ40545030
Nuclear import inhibitor N-(4-hydroxyphenyl) retinamide targets Zika virus (ZIKV) nonstructural protein 5 to inhibit ZIKV infection.Q41922059
Potent inhibition of NTPase/helicase of the West Nile Virus by ring-expanded ("fat") nucleoside analoguesQ42980688
Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virusQ43046703
Novel ring-expanded nucleoside analogs exhibit potent and selective inhibition of hepatitis B virus replication in cultured human hepatoblastoma cellsQ43828966
In vitro assays for studying helicase activities.Q45948232
Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatmentQ46312467
On the value of c: can low affinity systems be studied by isothermal titration calorimetry?Q47357121
Biochemical Differences and Similarities between the DEAD-Box Helicase Orthologs DDX3X and Ded1pQ47610758
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P577publication date2020-01-09
P1433published inCellsQ27724621
P1476titleRK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X
P478volume9

Reverse relations

Q112283513Cotranslational prolyl hydroxylation is essential for flavivirus biogenesiscites workP2860

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