A noncanonical function of cGAMP in inflammasome priming and activation.

scientific article

A noncanonical function of cGAMP in inflammasome priming and activation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20171749
P932PMC publication ID5716045
P698PubMed publication ID29030458

P50authorJenny TingQ50858300
Karen V. SwansonQ51485870
Avani A PendseQ88837229
Rachid El MorabitiQ89632923
Chris A BenedictQ89632926
P2093author name stringGlen N Barber
Robert D Junkins
Cathryn J Kurkjian
Elizabeth Holley-Guthrie
Alex Petrucelli
P2860cites workThe inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-betaQ24305136
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathwayQ24306635
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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNAQ24319765
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasomeQ24319799
Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanomaQ24320063
STING is an endoplasmic reticulum adaptor that facilitates innate immune signallingQ24336398
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomesQ24339219
The NAIP/NLRC4 inflammasomesQ26829603
Recognition of cytosolic DNA by cGAS and other STING-dependent sensorsQ27000358
Inflammasomes: mechanism of action, role in disease, and therapeuticsQ27001186
Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy.Q27322490
Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 ReceptorQ27678368
Innate immune recognition of DNA: A recent historyQ28080982
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNAQ28118718
Differential activation of the inflammasome by caspase-1 adaptors ASC and IpafQ28266417
Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activationQ28387955
Non-canonical inflammasome activation targets caspase-11Q28506831
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNAQ28585347
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA virusesQ29614469
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1Q29614473
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expressionQ29615589
K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matterQ29620146
Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.Q33665280
Mechanism of NLRP3 inflammasome activationQ33817836
Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malariaQ33927528
Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against SalmonellaQ34044445
Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activationQ34410101
The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signalingQ34417115
Dendritic cell programming by cytomegalovirus stunts naive T cell responses via the PD-L1/PD-1 pathway.Q34589567
Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infectionQ35177551
AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.Q35279584
Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenesQ35876024
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and AktQ35929017
STING manifests self DNA-dependent inflammatory diseaseQ36436812
MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signalsQ36845998
Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release.Q37031990
cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus InfectionQ37182691
Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasomeQ37252429
Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection.Q37298109
An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cellsQ37416793
Recognition of viruses by cytoplasmic sensorsQ37671348
STING-dependent cytosolic DNA sensing pathwaysQ38169005
Inflammasomes: mechanism of assembly, regulation and signallingQ38862650
cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signalingQ38972881
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta productionQ39774272
Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cellsQ39792930
Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus InfectionQ40287141
Dendritic cells under influence of mouse cytomegalovirus have a physiologic dual role: to initiate and to restrict T cell activationQ40660954
NLRP3 recruitment by NLRC4 during Salmonella infectionQ40690072
Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) effluxQ41108579
Caspase-11 protects against bacteria that escape the vacuoleQ41452200
Microbial modulation of host apoptosis and pyroptosisQ42702098
Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasomeQ42785062
Dendritic cells can be rapidly expanded ex vivo and safely administered in patients with metastatic breast cancerQ44927574
Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusionQ46823946
Type I Interferon Inhibits Interleukin-1 Production and Inflammasome ActivationQ57258441
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectinflammasome complexQ412405
P304page(s)3611-3626
P577publication date2017-10-13
P1433published inJournal of Experimental MedicineQ3186912
P1476titleA noncanonical function of cGAMP in inflammasome priming and activation
P478volume214

Reverse relations

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Q48280015cGAMP: A tale of two signals

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