scholarly article | Q13442814 |
P819 | ADS bibcode | 2017Sci...358..218W |
P356 | DOI | 10.1126/SCIENCE.AAN7969 |
P932 | PMC publication ID | 5714505 |
P698 | PubMed publication ID | 29026042 |
P50 | author | Paul Wender | Q15432981 |
Matthew C Stevens | Q56863299 | ||
Clayton Hardman | Q59748950 | ||
Jana K Maclaren | Q85041265 | ||
Akira Shimizu | Q89042815 | ||
Jack L Sloane | Q92092934 | ||
Stephen Ho | Q96025827 | ||
Matthew S Jeffreys | Q96025830 | ||
Ryan V Quiroz | Q96025833 | ||
Steven M Ryckbosch | Q96025835 | ||
P2093 | author name string | Stephen Ho | |
Paul A Wender | |||
Jana K Maclaren | |||
Matthew C Stevens | |||
Akira J Shimizu | |||
Clayton T Hardman | |||
Jack L Sloane | |||
Matthew S Jeffreys | |||
Ryan V Quiroz | |||
Steven M Ryckbosch | |||
P2860 | cites work | Total synthesis of bryostatin 7 via C-C bond-forming hydrogenation | Q24607710 |
Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches | Q24649951 | ||
A short history of SHELX | Q25938995 | ||
Reaction of the acetals with TESOTf-base combination; speculation of the intermediates and efficient mixed acetal formation | Q28196746 | ||
Protein kinase C: structure, function, and regulation | Q28618608 | ||
Structure validation in chemical crystallography | Q30485654 | ||
Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro | Q30558754 | ||
Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy | Q33331435 | ||
Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C | Q33651293 | ||
Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes | Q33687358 | ||
Bryostatin Effects on Cognitive Function and PKCɛ in Alzheimer's Disease Phase IIa and Expanded Access Trials | Q33708951 | ||
Total Synthesis of Bryostatin 3 | Q33913638 | ||
A new and more powerfully activating diamine for practical and scalable enantioselective aldehyde crotylsilylation reactions | Q34081568 | ||
Bryostatins: biological context and biotechnological prospects. | Q34145397 | ||
The practical synthesis of a novel and highly potent analogue of bryostatin | Q34158921 | ||
Total synthesis of bryostatin 9 | Q34187866 | ||
Total synthesis of bryostatin 1 | Q34538229 | ||
Synthetic studies on the bryostatins: preparation of a truncated BC-ring intermediate by pyran annulation | Q34686860 | ||
Pyran annulation: asymmetric synthesis of 2,6-disubstituted-4-methylene tetrahydropyrans | Q34686885 | ||
Total synthesis of (+)-acutiphycin | Q35141037 | ||
Bryostatin-1: a novel PKC inhibitor in clinical development | Q35634829 | ||
Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations. | Q35720063 | ||
Phase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant. | Q35733482 | ||
Protein Kinase C: One Pathway towards the Eradication of Latent HIV-1 Reservoirs | Q35830264 | ||
Total syntheses of bryostatins: synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragment | Q36452817 | ||
Protein kinase C, an elusive therapeutic target? | Q37141320 | ||
Simple one-pot conversion of aldehydes and ketones to enals | Q37317493 | ||
Lack of Overt Genome Reduction in the Bryostatin-Producing Bryozoan Symbiont "Candidatus Endobugula sertula". | Q37378672 | ||
Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease | Q37499816 | ||
New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo. | Q37695001 | ||
Determination of absolute structure using Bayesian statistics on Bijvoet differences. | Q40373988 | ||
Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy | Q40786377 | ||
Use of intensity quotients and differences in absolute structure refinement | Q40934629 | ||
SHELXT - integrated space-group and crystal-structure determination | Q41653750 | ||
Human immunodeficiency virus reactivation by phorbol esters or T-cell receptor ligation requires both PKCalpha and PKCtheta | Q42929742 | ||
Prolonging microtubule dysruption enhances the immunogenicity of chronic lymphocytic leukaemia cells | Q43279666 | ||
Sequential catalytic asymmetric allylic transfer reaction: enantioselective and diastereoselective construction of tetrahydropyran units | Q44255502 | ||
A Novel and General α-Regioselective and Highly Enantioselective Prenylation of Aldehydes | Q44412503 | ||
Aquaculture of three phyla of marine invertebrates to yield bioactive metabolites: process developments and economics | Q44550339 | ||
Effect of serum and antioxidants on the immunogenicity of protein kinase C-activated chronic lymphocytic leukemia cells | Q45024608 | ||
Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons | Q46941950 | ||
Catalytic Asymmetric Dihydroxylation | Q55877980 | ||
Variation in Growth Rate and Reproduction of the BryozoanBugula neritina | Q56188622 | ||
Directed reduction of .beta.-hydroxy ketones employing tetramethylammonium triacetoxyborohydride | Q56505805 | ||
ASYMMETRIC HYDROGENATION OF 3-OXO CARBOXYLATES USING BINAP-RUTHENIUM COMPLEXES: (R)-(−)-METHYL 3-HYDROXYBUTANOATE | Q56679498 | ||
OLEX2: a complete structure solution, refinement and analysis program | Q56812809 | ||
Isolation and structure of bryostatin 1 | Q57255655 | ||
Total Synthesis of Bryostatin 2 | Q57255656 | ||
Synthesis of bryostatin 7 | Q57255658 | ||
Antineoplastic Components of Marine Animals | Q59090309 | ||
The large-scale isolation of bryostatin 1 from Bugula neritina following current good manufacturing practices | Q67872610 | ||
New, abridged pathway to Masamune's "southern hemisphere" intermediate for the total synthesis of bryostatin 7 | Q72990907 | ||
The first and highly enantioselective crotylation of aldehydes via an allyl-transfer reaction from a chiral crotyl-donor | Q74502310 | ||
A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide | Q81327469 | ||
P433 | issue | 6360 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | bryostatin 1 | Q27095907 |
P304 | page(s) | 218-223 | |
P577 | publication date | 2017-10-01 | |
P1433 | published in | Science | Q192864 |
P1476 | title | Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV. | |
P478 | volume | 358 |
Q50061733 | Addressing supply issues for natural products in the clinic |
Q54978212 | Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents. |
Q57255660 | Chemoenzymatic Dissection of Polyketide β-Branching in the Bryostatin Pathway |
Q58568333 | Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1 |
Q89697243 | Evaluation of Toxic Amyloid 42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator |
Q53825808 | Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs). |
Q64887003 | Marine Spirotetronates: Biosynthetic Edifices That Inspire Drug Discovery. |
Q93057430 | Munc13 Is a Molecular Target of Bryostatin 1 |
Q90192470 | Natural Products as a Foundation for Drug Discovery |
Q58862085 | Natural product-derived compounds in HIV suppression, remission, and eradication strategies |
Q49384958 | REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment |
Q92092942 | Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy |
Q51146455 | The Who, Why, and How of Small-Molecule Production in Invertebrate Microbiomes: Basic Insights Fueling Drug Discovery. |
Q48168987 | Total Synthesis of Bryostatin 8 Using an Organosilane-Based Strategy. |
Search more.