Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV.

scientific article

Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2017Sci...358..218W
P356DOI10.1126/SCIENCE.AAN7969
P932PMC publication ID5714505
P698PubMed publication ID29026042

P50authorPaul WenderQ15432981
Matthew C StevensQ56863299
Clayton HardmanQ59748950
Jana K MaclarenQ85041265
Akira ShimizuQ89042815
Jack L SloaneQ92092934
Stephen HoQ96025827
Matthew S JeffreysQ96025830
Ryan V QuirozQ96025833
Steven M RyckboschQ96025835
P2093author name stringStephen Ho
Paul A Wender
Jana K Maclaren
Matthew C Stevens
Akira J Shimizu
Clayton T Hardman
Jack L Sloane
Matthew S Jeffreys
Ryan V Quiroz
Steven M Ryckbosch
P2860cites workTotal synthesis of bryostatin 7 via C-C bond-forming hydrogenationQ24607710
Total synthesis of bryostatin 16 using atom-economical and chemoselective approachesQ24649951
A short history of SHELXQ25938995
Reaction of the acetals with TESOTf-base combination; speculation of the intermediates and efficient mixed acetal formationQ28196746
Protein kinase C: structure, function, and regulationQ28618608
Structure validation in chemical crystallographyQ30485654
Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitroQ30558754
Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategyQ33331435
Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase CQ33651293
Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranesQ33687358
Bryostatin Effects on Cognitive Function and PKCɛ in Alzheimer's Disease Phase IIa and Expanded Access TrialsQ33708951
Total Synthesis of Bryostatin 3Q33913638
A new and more powerfully activating diamine for practical and scalable enantioselective aldehyde crotylsilylation reactionsQ34081568
Bryostatins: biological context and biotechnological prospects.Q34145397
The practical synthesis of a novel and highly potent analogue of bryostatinQ34158921
Total synthesis of bryostatin 9Q34187866
Total synthesis of bryostatin 1Q34538229
Synthetic studies on the bryostatins: preparation of a truncated BC-ring intermediate by pyran annulationQ34686860
Pyran annulation: asymmetric synthesis of 2,6-disubstituted-4-methylene tetrahydropyransQ34686885
Total synthesis of (+)-acutiphycinQ35141037
Bryostatin-1: a novel PKC inhibitor in clinical developmentQ35634829
Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations.Q35720063
Phase II study of bryostatin 1 and vincristine for aggressive non-Hodgkin lymphoma relapsing after an autologous stem cell transplant.Q35733482
Protein Kinase C: One Pathway towards the Eradication of Latent HIV-1 ReservoirsQ35830264
Total syntheses of bryostatins: synthesis of two ring-expanded bryostatin analogues and the development of a new-generation strategy to access the C7-C27 fragmentQ36452817
Protein kinase C, an elusive therapeutic target?Q37141320
Simple one-pot conversion of aldehydes and ketones to enalsQ37317493
Lack of Overt Genome Reduction in the Bryostatin-Producing Bryozoan Symbiont "Candidatus Endobugula sertula".Q37378672
Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's diseaseQ37499816
New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.Q37695001
Determination of absolute structure using Bayesian statistics on Bijvoet differences.Q40373988
Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapyQ40786377
Use of intensity quotients and differences in absolute structure refinementQ40934629
SHELXT - integrated space-group and crystal-structure determinationQ41653750
Human immunodeficiency virus reactivation by phorbol esters or T-cell receptor ligation requires both PKCalpha and PKCthetaQ42929742
Prolonging microtubule dysruption enhances the immunogenicity of chronic lymphocytic leukaemia cellsQ43279666
Sequential catalytic asymmetric allylic transfer reaction: enantioselective and diastereoselective construction of tetrahydropyran unitsQ44255502
A Novel and General α-Regioselective and Highly Enantioselective Prenylation of AldehydesQ44412503
Aquaculture of three phyla of marine invertebrates to yield bioactive metabolites: process developments and economicsQ44550339
Effect of serum and antioxidants on the immunogenicity of protein kinase C-activated chronic lymphocytic leukemia cellsQ45024608
Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbonsQ46941950
Catalytic Asymmetric DihydroxylationQ55877980
Variation in Growth Rate and Reproduction of the BryozoanBugula neritinaQ56188622
Directed reduction of .beta.-hydroxy ketones employing tetramethylammonium triacetoxyborohydrideQ56505805
ASYMMETRIC HYDROGENATION OF 3-OXO CARBOXYLATES USING BINAP-RUTHENIUM COMPLEXES: (R)-(−)-METHYL 3-HYDROXYBUTANOATEQ56679498
OLEX2: a complete structure solution, refinement and analysis programQ56812809
Isolation and structure of bryostatin 1Q57255655
Total Synthesis of Bryostatin 2Q57255656
Synthesis of bryostatin 7Q57255658
Antineoplastic Components of Marine AnimalsQ59090309
The large-scale isolation of bryostatin 1 from Bugula neritina following current good manufacturing practicesQ67872610
New, abridged pathway to Masamune's "southern hemisphere" intermediate for the total synthesis of bryostatin 7Q72990907
The first and highly enantioselective crotylation of aldehydes via an allyl-transfer reaction from a chiral crotyl-donorQ74502310
A mild and selective method for the hydrolysis of esters with trimethyltin hydroxideQ81327469
P433issue6360
P407language of work or nameEnglishQ1860
P921main subjectbryostatin 1Q27095907
P304page(s)218-223
P577publication date2017-10-01
P1433published inScienceQ192864
P1476titleScalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV.
P478volume358

Reverse relations

cites work (P2860)
Q50061733Addressing supply issues for natural products in the clinic
Q54978212Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents.
Q57255660Chemoenzymatic Dissection of Polyketide β-Branching in the Bryostatin Pathway
Q58568333Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1
Q89697243Evaluation of Toxic Amyloid 42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator
Q53825808Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs).
Q64887003Marine Spirotetronates: Biosynthetic Edifices That Inspire Drug Discovery.
Q93057430Munc13 Is a Molecular Target of Bryostatin 1
Q90192470Natural Products as a Foundation for Drug Discovery
Q58862085Natural product-derived compounds in HIV suppression, remission, and eradication strategies
Q49384958REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment
Q92092942Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy
Q51146455The Who, Why, and How of Small-Molecule Production in Invertebrate Microbiomes: Basic Insights Fueling Drug Discovery.
Q48168987Total Synthesis of Bryostatin 8 Using an Organosilane-Based Strategy.

Search more.