Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers

scientific article published on 16 October 2017

Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10555-017-9709-6
P698PubMed publication ID29039083

P2093author name stringChing-Hsien Chen
David C Yang
Lon Wolf R Fong
P2860cites workDirect involvement of protein myristoylation in myristoylated alanine-rich C kinase substrate (MARCKS)-calmodulin interaction.Q44594134
Involvement of Rho-kinase in inflammatory and neuropathic pain through phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS).Q45263165
MARCKS actin-binding capacity mediates actin filament assembly during mitosis in human hepatic stellate cells.Q53171098
Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation.Q53305406
Dissociation of phosphorylation and translocation of a myristoylated protein kinase C substrate (MARCKS protein) in C6 glioma and N1E-115 neuroblastoma cells.Q55482973
The Effector Domain of Myristoylated Alanine-rich C Kinase Substrate Binds Strongly to Phosphatidylinositol 4,5-BisphosphateQ57371944
The bi-directional translocation of MARCKS between membrane and cytosol regulates integrin-mediated muscle cell spreadingQ57375243
MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulinQ24323363
Tob-mediated cross-talk between MARCKS phosphorylation and ErbB-2 activationQ28186288
MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitroQ28215052
Myristoylated alanine-rich C kinase substrate (MARCKS) sequesters spin-labeled phosphatidylinositol 4,5-bisphosphate in lipid bilayersQ28217297
The MARCKS family of phospholipid binding proteins: regulation of phospholipase D and other cellular componentsQ28253543
The MARCKS family of protein kinase-C substratesQ28273578
Expression of MARCKS effector domain mutants alters phospholipase D activity and cytoskeletal morphology of SK-N-MC neuroblastoma cellsQ28575172
Dynamic adhesions and MARCKS in melanoma cellsQ28579253
The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactionsQ29010955
Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteinsQ30447412
The MARCKS protein plays a critical role in phosphatidylinositol 4,5-bisphosphate metabolism and directed cell movement in vascular endothelial cellsQ30497948
MARCKS phosphorylation is modulated by a peptide mimetic of MARCKS effector domain leading to increased radiation sensitivity in lung cancer cell linesQ33597596
Tumor necrosis factor alpha modifies agonist-dependent responses in human neutrophils by inducing the synthesis and myristoylation of a specific protein kinase C substrateQ33706259
Inhibition of myristoylated alanine-rich C kinase substrate (MARCKS) protein inhibits ozone-induced airway neutrophilia and inflammationQ33781030
PhosphoMARCKS drives motility of mouse melanoma cellsQ33814631
Activation of protein kinase C isoforms and its impact on diabetic complicationsQ33881442
Role of AKT signaling in DNA repair and clinical response to cancer therapyQ34193741
Myristoylated alanine-rich C kinase substrate (MARCKS) produces reversible inhibition of phospholipase C by sequestering phosphatidylinositol 4,5-bisphosphate in lateral domains.Q34398956
Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein.Q34805664
Global characterization of signalling networks associated with tamoxifen resistance in breast cancer.Q34857146
Targeting myristoylated alanine-rich C kinase substrate phosphorylation site domain in lung cancer. Mechanisms and therapeutic implicationsQ34987170
The MARCKS brothers: a family of protein kinase C substratesQ35476852
Elevated MARCKS phosphorylation contributes to unresponsiveness of breast cancer to paclitaxel treatmentQ36020972
Directed migration of mouse macrophages in vitro involves myristoylated alanine-rich C-kinase substrate (MARCKS) proteinQ36188854
Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS proteinQ36202835
A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasisQ36244135
A myristoylated alanine-rich C kinase substrate-related peptide suppresses cytokine mRNA and protein expression in LPS-activated canine neutrophilsQ36703999
Myristoylated Alanine-Rich Protein Kinase Substrate (MARCKS) Regulates Small GTPase Rac1 and Cdc42 Activity and Is a Critical Mediator of Vascular Smooth Muscle Cell Migration in Intimal Hyperplasia FormationQ36835981
Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling PathwayQ36849876
In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation.Q36954876
A peptide against the N-terminus of myristoylated alanine-rich C kinase substrate inhibits degranulation of human leukocytes in vitroQ37101145
MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for gliomaQ37130116
Protein kinase C intervention: the state of playQ37398291
MARCKS protein overexpression in inflammatory breast cancerQ37701585
miR‑34c‑3p acts as a tumor suppressor gene in osteosarcoma by targeting MARCKS.Q37722111
Regulation of mucin secretion and inflammation in asthma: a role for MARCKS protein?Q37833718
Subcellular fate and off-target effects of siRNA, shRNA, and miRNA.Q37950261
Contribution of individual PKC isoforms to breast cancer progressionQ37957811
Peptide therapeutics: current status and future directionsQ38275750
Myoblast migration is prevented by a calpain-dependent accumulation of MARCKS.Q38346034
Molecular basis of resistance to proteasome inhibitors in hematological malignanciesQ38351357
RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?Q38688625
MicroRNA-34c-3p promotes cell proliferation and invasion in hepatocellular carcinoma by regulation of NCKAP1 expressionQ38742442
Secretome protein signature of human pancreatic cancer stem-like cellsQ38796126
Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivityQ38927046
Targeting phospho-MARCKS overcomes drug-resistance and induces antitumor activity in preclinical models of multiple myelomaQ38960661
Upregulation of MARCKS in kidney cancer and its potential as a therapeutic targetQ38976447
Functional characterization of the tumor-suppressor MARCKS in colorectal cancer and its association with survivalQ39012262
MicroRNA therapeutics: towards a new era for the management of cancer and other diseasesQ39139786
Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivoQ39200403
FDA-Approved Oligonucleotide Therapies in 2017.Q39214058
Targeting PI3K Signaling in Combination Cancer Therapy.Q39441303
Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway.Q39756253
Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpressionQ39796348
MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cellsQ39870137
Quantitative Tissue Proteomics Analysis Reveals Versican as Potential Biomarker for Early-Stage Hepatocellular CarcinomaQ40253359
PKC phosphorylates MARCKS Ser159 not only directly but also through RhoA/ROCK.Q40283261
Myristoylated alanine-rich C kinase substrate-mediated neurotensin release via protein kinase C-delta downstream of the Rho/ROK pathway.Q40476398
Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathwayQ40595058
Myristoylated alanine-rich C-kinase substrate (MARCKS) protein regulation of human neutrophil migration.Q40684672
Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.Q40724768
GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanismQ40871328
Membrane association of the myristoylated alanine-rich C kinase substrate (MARCKS) protein. Mutational analysis provides evidence for complex interactionsQ41336364
PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome.Q41526004
Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling ModuleQ41988796
MARCKS promotes invasion and is associated with biochemical recurrence in prostate cancer.Q42700841
A novel predictor of cancer malignancy: up-regulation of myristoylated alanine-rich C kinase substrate phosphorylation in lung cancerQ42735841
Current challenges in peptide-based drug discoveryQ42778271
Actin filament cross-linking by MARCKS: characterization of two actin-binding sites within the phosphorylation site domain.Q43569558
Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membraneQ43785024
Myristoylated alanine-rich C-kinase substrate as a prognostic biomarker in human primary lung squamous cell carcinomaQ44218241
Involvement of PKCdelta and PKD in pulmonary microvascular endothelial cell hyperpermeabilityQ44588542
P433issue4
P304page(s)737-747
P577publication date2017-10-16
P1433published inCancer and Metastasis ReviewsQ2647982
P1476titleMyristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers
P478volume36

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cites work (P2860)
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Q58093747Involvement of dual-strand of the miR-144 duplex and their targets in the pathogenesis of lung squamous cell carcinoma
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Q89597183WNT5A-Induced Activation of the Protein Kinase C Substrate MARCKS Is Required for Melanoma Cell Invasion