Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein

scientific article

Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2353/AJPATH.2007.070318
P932PMC publication ID2111106
P698PubMed publication ID18055557
P5875ResearchGate publication ID5791759

P2093author name stringKenneth B Adler
Shijing Fang
Jin-Ah Park
Joungjoa Park
Anne L Crews
William R Lampe
P2860cites workProtein kinase C-delta is a negative regulator of antigen-induced mast cell degranulationQ24537442
Specificity of the high affinity interaction of protein kinase C with a physiological substrate, myristoylated alanine-rich protein kinase C substrate.Q27865303
MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitroQ28215052
The Myristoylated Alanine‐Rich C‐Kinase Substrate (MARCKS) is Sequentially Phosphorylated by Conventional, Novel and Atypical Isotypes of Protein Kinase CQ28291411
Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vectorQ28343705
Specificity and mechanism of action of some commonly used protein kinase inhibitorsQ28344791
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase CQ29620247
Chemistry and clinical biology of the bryostatinsQ34043857
Airway epithelium and mucus: intracellular signaling pathways for gene expression and secretionQ34428492
Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas?Q34537883
Rottlerin, a novel protein kinase inhibitorQ34727293
Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C{delta}-mediated mechanismQ35221784
Mucins: structure, function, and role in pulmonary diseasesQ35444248
Distinctive epidermal growth factor receptor/extracellular regulated kinase-independent and -dependent signaling pathways in the induction of airway mucin 5B and mucin 5AC expression by phorbol 12-myristate 13-acetateQ35570361
Increased localization and substrate activation of protein kinase C delta in lung epithelial cells following exposure to asbestosQ35747910
Respiratory tract mucin genes and mucin glycoproteins in health and diseaseQ36350071
Airway mucus: From production to secretion.Q36369409
Treatment of airway mucus hypersecretionQ36438219
(R)-albuterol elicits antiinflammatory effects in human airway epithelial cells via iNOS.Q37101038
Characterization of a protein kinase C-delta (PKC-delta) ATP binding mutant. An inactive enzyme that competitively inhibits wild type PKC-delta enzymatic activityQ38296695
Luminal leptin activates mucin-secreting goblet cells in the large bowelQ38316186
Nitric oxide induces MUC5AC mucin in respiratory epithelial cells through PKC and ERK dependent pathwaysQ38506533
Upregulation of PKC-delta contributes to antiestrogen resistance in mammary tumor cells.Q40453538
Myristoylated alanine-rich C kinase substrate-mediated neurotensin release via protein kinase C-delta downstream of the Rho/ROK pathway.Q40476398
VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epitheliumQ40503231
Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C deltaQ40646086
Asbestos-induced apoptosis is protein kinase C delta-dependentQ40665640
Mucin secretion and PKC isoforms in SPOC1 goblet cells: differential activation by purinergic agonist and PMA.Q40670512
PKCdelta is required for mitochondrial-dependent apoptosis in salivary epithelial cells.Q40803922
Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro. Signaling pathways controlling surface and gene expressionQ40876113
Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells.Q40954058
Ca2+ and protein kinase C activation of mucin granule exocytosis in permeabilized SPOC1 cells.Q41019821
The catalytic domain of protein kinase C-delta in reciprocal delta and epsilon chimeras mediates phorbol ester-induced macrophage differentiation of mouse promyelocytesQ41135284
Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -etaQ41526536
Papilloma virus immortalized tracheal epithelial cells retain a well-differentiated phenotypeQ41553917
A role for protein kinase cepsilon in the inhibitory effect of epidermal growth factor on calcium-stimulated chloride secretion in human colonic epithelial cellsQ41734757
MARCKS phosphorylation by individual protein kinase C isozymes in insect Sf9 cellsQ42065032
Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblastsQ42802503
PKC epsilon -mediated ERK1/2 activation involved in radiation-induced cell death in NIH3T3 cellsQ42805420
Involvement of protein kinase Cdelta in contact-dependent inhibition of growth in human and murine fibroblastsQ42826098
Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B.Q43000879
Regulation of epithelial transport and barrier function by distinct protein kinase C isoformsQ43666374
Protein kinase C-mediated translocation of secretory vesicles to plasma membrane and enhancement of neurotransmitter release from PC12 cellsQ43982239
Potentiation of insulin secretion by phorbol esters is mediated by PKC-alpha and nPKC isoformsQ44176885
Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistanceQ44319393
Differential Role of Protein Kinase Cδ Isoform in Agonist-induced Dense Granule Secretion in Human PlateletsQ44631925
Protein kinase C potentiates cAMP-stimulated mouse duodenal mucosal bicarbonate secretion in vitroQ44722800
Protein kinase Cdelta functions downstream of Ca2+ mobilization in FcepsilonRI signaling to degranulation in mast cellsQ45145976
An ELISA method for the quantitation of tracheal mucins from human and nonhuman primatesQ46129529
Involvement of novel protein kinase C isoforms in carbachol-stimulated insulin secretion from rat pancreatic isletsQ46490573
Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expressionQ46727427
A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthmaQ48033163
Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiationQ57997655
ATP-induced mucin release from cultured airway goblet cells involves, in part, activation of protein kinase CQ73070937
Angiotensin II induces apoptosis of adult ventricular myocytes in vitroQ73342683
Protein kinase C and Ca2+ activation of mucin secretion in airway goblet cellsQ73575809
Isoform specificity of activators and inhibitors of protein kinase C gamma and deltaQ73775292
Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cellsQ79998841
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)1822-1830
P577publication date2007-11-30
P1433published inThe American Journal of PathologyQ4744259
P1476titleProtein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein
P478volume171

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cites work (P2860)
Q42046943A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence in sticklebacks
Q34425800A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation
Q39329209Calpain and MARCKS protein regulation of airway mucin secretion
Q34276479ENaC activity and expression is decreased in the lungs of protein kinase C-α knockout mice
Q36020972Elevated MARCKS phosphorylation contributes to unresponsiveness of breast cancer to paclitaxel treatment
Q36837862Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice
Q36954876In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation.
Q39387104Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.
Q53802302Involvement of myristoylated alanine-rich C kinase substrate phosphorylation and translocation in cholecystokinin-induced amylase release in rat pancreatic acini.
Q54664285Lysophosphatidylcholine-mediated functional inactivation of syndecan-4 results in decreased adhesion and motility of dendritic cells.
Q58585938MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) and Lung Disease
Q39732214MARCKS and related chaperones bind to unconventional myosin V isoforms in airway epithelial cells
Q43111829MARCKS is marked in combating lung cancer growth and acquired resistance
Q36057629MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging
Q90218690Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b
Q47642445Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers
Q34150094PKCθ synergizes with TLR-dependent TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA1.
Q36220074Phorbol 12-Myristate 13-Acetate Induces MUC16 Expression via PKCδ and p38 in Human Airway Epithelial Cells
Q46048215Phosphorylation of myristoylated alanine-rich C kinase substrate is involved in the cAMP-dependent amylase release in parotid acinar cells.
Q38265533Protein kinases are potential targets to treat inflammatory bowel disease
Q37180392Regulated mucin secretion from airway epithelial cells
Q37833718Regulation of mucin secretion and inflammation in asthma: a role for MARCKS protein?
Q39096298Role of calcium and PKC in salivary mucous cell exocrine secretion
Q90405873SCF/c-KIT signaling promotes mucus secretion of colonic goblet cells and development of mucinous colorectal adenocarcinoma
Q93350323Sodium channel TRPM4 and sodium/calcium exchangers (NCX) cooperate in the control of Ca2+-induced mucin secretion from goblet cells
Q34987170Targeting myristoylated alanine-rich C kinase substrate phosphorylation site domain in lung cancer. Mechanisms and therapeutic implications
Q36927112Taurolithocholate-induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase Cϵ in HUH-NTCP Cells
Q24292760The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress

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