Intracellular response to process optimization and impact on productivity and product aggregates for a high-titer CHO cell process.

scientific article published on 23 September 2017

Intracellular response to process optimization and impact on productivity and product aggregates for a high-titer CHO cell process. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/BIT.26460
P698PubMed publication ID28941283

P50authorSanjeev AhujaQ89058060
P2093author name stringMichael W Handlogten
Shailendra Singh
Gargi Roy
Sophia V Levitskaya
Raghavan Venkat
Allison Lee-O'Brien
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Simultaneous analysis of reactive oxygen species and reduced glutathione content in living cells by polychromatic flow cytometryQ33518424
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Cell culture processes for monoclonal antibody productionQ34125491
Protein disulfide isomerase: a critical evaluation of its function in disulfide bond formationQ34608269
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Cell culture models for oxidative stress: superoxide and hydrogen peroxide versus normobaric hyperoxiaQ35341324
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Protein disulfide isomerases contribute differentially to the endoplasmic reticulum-associated degradation of apolipoprotein B and other substratesQ35756661
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Antibodies to watch in 2017Q37631319
Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture processQ37941455
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Quality control: ER-associated degradation: protein quality control and beyondQ38196654
Screening and assessment of performance and molecule quality attributes of industrial cell lines across different fed-batch systemsQ38826159
Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cellsQ39446212
Culture temperature modulates aggregation of recombinant antibody in cho cellsQ39464481
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Correlation of heavy and light chain mRNA copy numbers to antibody productivity in mouse myeloma production cell linesQ40316914
How does mild hypothermia affect monoclonal antibody glycosylation?Q41643415
Promoting effect of beta-mercaptoethanol on in vitro development under oxidative stress and cystine uptake of bovine embryosQ43899518
Feeding lactate for CHO cell culture processes: impact on culture metabolism and performanceQ45196969
Investigation of metabolic variability observed in extended fed batch cell cultureQ45258279
Glutathione and thioredoxin systems contribute to recombinant monoclonal antibody interchain disulfide bond reduction during bioprocessingQ46244443
Effects of amino acid additions on ammonium stressed CHO cellsQ46464301
Effects of elevated pCO2 and osmolality on growth of CHO cells and production of antibody-fusion protein B1: a case studyQ46498440
Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumptionQ46843659
Advanced process monitoring and feedback control to enhance cell culture process production and robustness.Q50960286
On the optimal ratio of heavy to light chain genes for efficient recombinant antibody production by CHO cells.Q51461276
Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture.Q51754828
LC-MS-based metabolic characterization of high monoclonal antibody-producing Chinese hamster ovary cells.Q51758250
Effect of PDI overexpression on recombinant protein secretion in CHO cells.Q52583258
P433issue1
P304page(s)126-138
P577publication date2018-01-01
P1433published inBiotechnology and BioengineeringQ4915339
P1476titleIntracellular response to process optimization and impact on productivity and product aggregates for a high-titer CHO cell process
P478volume115

Reverse relations

cites work (P2860)
Q104503891Addressing patient to patient variability for autologous CAR T therapies
Q98892821Increased MSX level improves biological productivity and production stability in multiple recombinant GS CHO cell lines
Q100464535Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells
Q92481724Resolving the formidable barrier of oxygen transferring rate (OTR) in ultrahigh-titer bioconversion/biocatalysis by a sealed-oxygen supply biotechnology (SOS)

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