Cardiovascular Safety, Long-Term Noncardiovascular Safety, and Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis With Trial Sequential Analysis

scientific article published on 20 January 2018

Cardiovascular Safety, Long-Term Noncardiovascular Safety, and Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis With Trial Sequential Analysis is …
instance of (P31):
meta-analysisQ815382
scholarly articleQ13442814

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P356DOI10.1161/JAHA.117.007165
P932PMC publication ID5850151
P698PubMed publication ID29353233

P2093author name stringBiao Xu
Fu Chen
Qing-Qing Zhu
Xin-Lin Zhang
Jian-An Huang
Xue-Ling Li
Yu-Han Chen
P2860cites workManagement of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).Q22241288
Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular CausesQ22250883
Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysisQ24289436
Dipeptidyl peptidase-4 inhibitors and risk of heart failure in type 2 diabetes: systematic review and meta-analysis of randomised and observational studiesQ26765047
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statementQ27860606
Measuring inconsistency in meta-analysesQ27860655
Statistical aspects of the analysis of data from retrospective studies of diseaseQ27860916
Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitusQ28297680
Association of Cardiometabolic Multimorbidity With MortalityQ28606934
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetesQ29547541
Meta-Analysis of Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Cardiovascular Outcomes and All-Cause Mortality Among Patients With Type 2 Diabetes MellitusQ30245104
Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitusQ30249371
Long-term glycaemic response and tolerability of dapagliflozin versus a sulphonylurea as add-on therapy to metformin in patients with type 2 diabetes: 4-year data.Q30903369
What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse dataQ30926358
Apparently conclusive meta-analyses may be inconclusive--Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analysesQ33372680
Long-term effects of intensive glucose lowering on cardiovascular outcomesQ33851861
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 DiabetesQ34540403
Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trialQ34593046
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 DiabetesQ34673134
Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis.Q35968414
Liraglutide and Cardiovascular Outcomes in Type 2 DiabetesQ36050559
Evaluation of Bone Mineral Density and Bone Biomarkers in Patients With Type 2 Diabetes Treated With CanagliflozinQ36431654
Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetesQ38218644
Lower Risk of Heart Failure and Death in Patients Initiated on Sodium-Glucose Cotransporter-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study (Comparative Effectiveness of Cardiovascular Outcomes in New Users of Sodium-Glucose CotQ38376619
Heart failure in diabetes: effects of anti-hyperglycaemic drug therapyQ38502148
Acute Kidney Injury in Patients on SGLT2 Inhibitors: A Propensity-Matched Analysis.Q38615440
Ketoacidosis and SGLT2 inhibitor treatment: Analysis of FAERS data.Q38665387
Canagliflozin and Cardiovascular and Renal Events in Type 2 DiabetesQ38729780
Cardiovascular outcomes with sodium-glucose cotransporter-2 inhibitors in patients with type II diabetes mellitus: A meta-analysis of placebo-controlled randomized trialsQ38793234
Sodium-glucose cotransporter-2 inhibition for the reduction of cardiovascular events in high-risk patients with diabetes mellitusQ38827756
Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications.Q38912082
Cardiovascular Protection by Sodium Glucose Cotransporter 2 Inhibitors: Potential MechanismsQ39318765
Novel Diabetes Drugs and the Cardiovascular SpecialistQ39330831
Long-term efficacy and safety of canagliflozin over 104 weeks in patients aged 55-80 years with type 2 diabetesQ41605742
Canagliflozin provides durable glycemic improvements and body weight reduction over 104 weeks versus glimepiride in patients with type 2 diabetes on metformin: a randomized, double-blind, phase 3 studyQ41745784
Increased amputation risk with canagliflozin treatment: behind the large cardiovascular benefit?Q42376494
Cumulating evidence from randomized trials: utilizing sequential monitoring boundaries for cumulative meta-analysisQ43471039
2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice GuidelinesQ44265041
Genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus: a pooled analysis of clinical studiesQ44438668
Efficacy and Safety of Canagliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, as Add-on to Insulin in Patients With Type 1 DiabetesQ45190512
Dapagliflozin in patients with type 2 diabetes receiving high doses of insulin: efficacy and safety over 2 yearsQ47871792
Incidence of Ketoacidosis in the Danish Type 2 Diabetes Population Before and After Introduction of Sodium-Glucose Cotransporter 2 Inhibitors-A Nationwide, Retrospective Cohort Study, 1995-2014.Q48138412
Sodium-Glucose Cotransporter 2 Inhibitors and Diabetic Ketoacidosis: A Case Series From Three Academic InstitutionsQ48350642
Risk of lower extremity amputations in people with type 2 diabetes mellitus treated with sodium-glucose co-transporter-2 inhibitors in the USA: A retrospective cohort studyQ48360915
Cardiovascular Outcomes and Risks After Initiation of a Sodium Glucose Cotransporter 2 Inhibitor: Results From the EASEL Population-Based Cohort Study (Evidence for Cardiovascular Outcomes With Sodium Glucose Cotransporter 2 Inhibitors in the Real WQ50042476
SGLT2 inhibitors: hypotheses on the mechanism of cardiovascular protection.Q50066726
Cardiac effects of SGLT2 inhibitors: the sodium hypothesis.Q50089120
Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 InhibitorQ50955035
Sodium-glucose cotransporter 2 inhibition and glycemic control in type 1 diabetes: results of an 8-week open-label proof-of-concept trial.Q51326175
Effects of Sodium-Glucose Cotransporter 2 Inhibitors for the Treatment of Patients With Heart Failure: Proposal of a Novel Mechanism of Action.Q51832630
Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes.Q53084508
2013 ESC guidelines on the management of stable coronary artery diseaseQ57243329
Thiazolidinediones and Heart Failure: A teleo-analysisQ57413498
Assessing the cardiovascular safety of diabetes therapiesQ81950632
Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: a 104-week randomised, active-controlled, double-blind, phase 3 trialQ88117871
SGLT2 inhibitors and amputations in the US FDA Adverse Event Reporting SystemQ88579083
P433issue2
P921main subjecttype 2 diabetesQ3025883
P577publication date2018-01-20
P1433published inJournal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseQ19880670
P1476titleCardiovascular Safety, Long-Term Noncardiovascular Safety, and Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis With Trial Sequential Analysis
P478volume7

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cites work (P2860)
Q90732416Appraisal of Non-Cardiovascular Safety for Sodium-Glucose Co-Transporter 2 Inhibitors: A Systematic Review and Meta-Analysis of Placebo-Controlled Randomized Clinical Trials
Q92805657Cardiorenal Protection: Potential of SGLT2 Inhibitors and GLP-1 Receptor Agonists in the Treatment of Type 2 Diabetes
Q92355579Cardiovascular and Renal Benefits of SGLT2 Inhibitors: A Narrative Review
Q91725845Effects of sodium-glucose cotransporter 2 inhibitors on risk of venous thromboembolism in patients with type 2 diabetes: A systematic review and meta-analysis
Q58576729Efficacy and safety of sodium-glucose cotransporter 2 inhibitors (SGLT-2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) in patients with type 2 diabetes: a systematic review and network meta-analysis study protocol
Q88969119Glycaemic control in the diabetes and Lifestyle Cohort Twente: A cross-sectional assessment of lifestyle and pharmacological management on Hba1c target achievement
Q92108931Importance of sodium-glucose cotransporter 2 inhibitor use in diabetic patients with acute heart failure
Q57026285Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Q56979722Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Q92435311Novel natural and synthetic inhibitors of solute carriers SGLT1 and SGLT2
Q92835456Rationale for the Early Use of Sodium-Glucose Cotransporter-2 Inhibitors in Patients with Type 2 Diabetes
Q92703271SGLT2 Inhibitors: A Review of Their Antidiabetic and Cardioprotective Effects
Q59330606Sodium glucose cotransporter 2 inhibitors and risk of serious adverse events: nationwide register based cohort study
Q90470148Sodium-glucose cotransporter 2 inhibitors for diabetic kidney disease: a primer for deprescribing
Q64916602The CANVAS Program: implications of canagliflozin on reducing cardiovascular risk in patients with type 2 diabetes mellitus.
Q92992644Use of sodium glucose cotransporter 2 inhibitors and risk of major cardiovascular events and heart failure: Scandinavian register based cohort study
Q92608090What Next After Metformin? Thinking Beyond Glycaemia: Are SGLT2 Inhibitors the Answer?

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