Tenomodulin is essential for prevention of adipocyte accumulation and fibrovascular scar formation during early tendon healing

scientific article

Tenomodulin is essential for prevention of adipocyte accumulation and fibrovascular scar formation during early tendon healing is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/CDDIS.2017.510
P932PMC publication ID5682675
P698PubMed publication ID29022912

P50authorMatthias SchiekerQ56947533
Denitsa DochevaQ56978370
P2093author name stringDasheng Lin
Paolo Alberton
Elias Volkmer
Manuel Delgado Caceres
P2860cites workHealing parameters in a rabbit partial tendon defect following tenocyte/biomaterial implantation.Q52896492
Fatty infiltration and atrophy of the rotator cuff do not improve after rotator cuff repair and correlate with poor functional outcome.Q53710117
Achilles tendon healing: long-term biomechanical effects of postoperative mobilization and immobilization in a new mouse modelQ78382185
Ectopic chondro-ossification and erroneous extracellular matrix deposition in a tendon window injury modelQ84563185
Tenogenic modulating insider factor: Systematic assessment on the functions of tenomodulin geneQ26748847
Lineage tracing of resident tendon progenitor cells during growth and natural healingQ27335062
Mechanisms of tendon injury and repairQ28088714
Molecular cloning and characterization of CHM1L, a novel membrane molecule similar to chondromodulin-IQ28577215
Tendon-derived stem/progenitor cell aging: defective self-renewal and altered fateQ28582253
Tendon regeneration and scar formation: The concept of scarless healingQ29042595
Adipocyte differentiation from the inside outQ29615690
Mechanisms of fibrosis: therapeutic translation for fibrotic diseaseQ29620307
Harnessing endogenous stem/progenitor cells for tendon regeneration.Q30664042
Tenomodulin is necessary for tenocyte proliferation and tendon maturationQ30979772
Molecular cloning of tenomodulin, a novel chondromodulin-I related geneQ31856755
A high-glucose diet affects Achilles tendon healing in ratsQ33677547
The early inflammatory response after flexor tendon healing: a gene expression and histological analysisQ33825344
Transplantation of fetal instead of adult fibroblasts reduces the probability of ectopic ossification during tendon repairQ33863546
A novel gene, tendin, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin-I.Q33947190
Anti-angiogenic action of the C-terminal domain of tenomodulin that shares homology with chondromodulin-I.Q34321659
Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cellsQ34445255
FGF-2 Stimulates the Growth of Tenogenic Progenitor Cells to Facilitate the Generation of Tenomodulin-Positive Tenocytes in a Rat Rotator Cuff Healing ModelQ34491130
Inhibition of 5-LOX, COX-1, and COX-2 increases tendon healing and reduces muscle fibrosis and lipid accumulation after rotator cuff repairQ34579999
Weight reduction modulates expression of genes involved in extracellular matrix and cell death: the GENOBIN studyQ34686210
The genetic variation in the tenomodulin gene is associated with serum total and LDL cholesterol in a body size-dependent mannerQ34871904
Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight lossQ34992294
Biologic aspects of flexor tendon laceration and repair.Q35085449
PPARγ: a circadian transcription factor in adipogenesis and osteogenesisQ35093192
S-nitrosoglutathione reductase-dependent PPARγ denitrosylation participates in MSC-derived adipogenesis and osteogenesisQ35408904
Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair.Q35757136
Biologics for tendon repairQ35900746
Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansionQ36591198
Molecular targets for tendon neoformationQ37075895
The effect of mesenchymal stromal cell sheets on the inflammatory stage of flexor tendon healingQ37291748
PPARγ signaling and metabolism: the good, the bad and the futureQ37407887
Single-cell analysis reveals a nestin+ tendon stem/progenitor cell population with strong tenogenic potentialityQ37603848
Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposureQ37620707
Tenomodulin gene and obesity-related phenotypesQ37739467
RelA/p65 inhibition prevents tendon adhesion by modulating inflammation, cell proliferation, and apoptosisQ37745427
Mechanisms of fatty degeneration in massive rotator cuff tearsQ37975611
Macrophages: supportive cells for tissue repair and regeneration.Q38147624
Liver fibrosis and repair: immune regulation of wound healing in a solid organQ38190875
Progress in cell-based therapies for tendon repair.Q38301498
Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiationQ38308746
Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenanceQ38324859
Tendon injury: from biology to tendon repairQ38367195
Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degenerationQ38488406
Dissecting fibrosis: therapeutic insights from the small-molecule toolboxQ38580461
Combined Administration of ASCs and BMP-12 Promotes an M2 Macrophage Phenotype and Enhances Tendon HealingQ38688704
Enhanced tenogenic differentiation and tendon-like tissue formation by tenomodulin overexpression in murine mesenchymal stem cellsQ38776650
Periodontal ligament cells as alternative source for cell-based therapy of tendon injuries: in vivo study of full-size Achilles tendon defect in a rat modelQ38808758
Molecular characterization and function of tenomodulin, a marker of tendons and ligaments that integrate musculoskeletal componentsQ39241879
Histopathological changes preceding spontaneous rupture of a tendon. A controlled study of 891 patientsQ39245511
Molecular events of cellular apoptosis and proliferation in the early tendon healing periodQ39917304
Activation of EphA4 and EphB2 Reverse Signaling Restores the Age-Associated Reduction of Self-Renewal, Migration, and Actin Turnover in Human Tendon Stem/Progenitor Cells.Q40095672
Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche.Q40175991
Pleiotropic roles of the matricellular protein Sparc in tendon maturation and ageingQ41002949
Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical LoadQ41084764
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytesQ42820082
The genetic variation of the tenomodulin gene (TNMD) is associated with serum levels of systemic immune mediators--the Finnish Diabetes Prevention StudyQ46518545
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue10
P921main subjectadipocyteQ357519
P304page(s)e3116
P577publication date2017-10-12
P1433published inCell Death and DiseaseQ2197222
P1476titleTenomodulin is essential for prevention of adipocyte accumulation and fibrovascular scar formation during early tendon healing
P478volume8

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cites work (P2860)
Q93052965Absence of estrogen receptor beta leads to abnormal adipogenesis during early tendon healing by an up-regulation of PPARγ signalling
Q92933602Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway
Q101477936Bringing tendon biology to heel: Leveraging mechanisms of tendon development, healing, and regeneration to advance therapeutic strategies
Q89977189EGR1 Transcription Factor is a Multifaceted Regulator of Matrix Production in Tendons and Other Connective Tissues
Q64118337Effects of X-chromosome Tenomodulin Genetic Variants on Obesity in a Children's Cohort and Implications of the Gene in Adipocyte Metabolism
Q93020518Extracellular vesicles from bone marrow-derived multipotent mesenchymal stromal cells regulate inflammation and enhance tendon healing
Q99555728In Vitro Innovation of Tendon Tissue Engineering Strategies
Q92960667Intraarticular Ligament Degeneration Is Interrelated with Cartilage and Bone Destruction in Osteoarthritis
Q89829122Loss of tenomodulin expression is a risk factor for age-related intervertebral disc degeneration
Q96137814Microsurgical reconstruction affects the outcome in a translational mouse model for Achilles tendon healing
Q89870477Models of tendon development and injury
Q64064348Molecular changes to tendons after collagenase-induced acute tendon injury in a senescence-accelerated mouse model
Q64238482Tenogenic differentiation protocol in xenogenic-free media enhances tendon-related marker expression in ASCs
Q91677830The cellular basis of fibrotic tendon healing: challenges and opportunities
Q90470411The splicing FK506-binding protein-51 isoform plays a role in glioblastoma resistance through programmed cell death ligand-1 expression regulation
Q57166261Understanding Tendons: Lessons from Transgenic Mouse Models

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