The conserved AU dinucleotide at the 5' end of nascent U1 snRNA is optimized for the interaction with nuclear cap-binding-complex.

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The conserved AU dinucleotide at the 5' end of nascent U1 snRNA is optimized for the interaction with nuclear cap-binding-complex. is …
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scholarly articleQ13442814

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P356DOI10.1093/NAR/GKX608
P932PMC publication ID5766165
P698PubMed publication ID28934473

P50authorShih-Hsin HuangQ79679291
Amy LarsonQ89043031
P2093author name stringShang-Lin Chang
Jui-Hui Chen
Tien-Hsien Chang
Jeffrey A Pleiss
Chung-Shu Yeh
Chun-Hsiung Wang
Wei-Hau Chang
Hsuan-Kai Wang
Yue-Chang Chou
P2860cites workCloning and domain structure of the mammalian splicing factor U2AFQ24305104
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Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNAQ24315080
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Cotranscriptional spliceosome assembly occurs in a stepwise fashion and requires the cap binding complexQ50336085
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A functional association between the 5' and 3' splice site is established in the earliest prespliceosome complex (E) in mammalsQ70744375
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Ribosomal protein L32 of Saccharomyces cerevisiae regulates both splicing and translation of its own transcriptQ72913151
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Composition of yeast snRNPs and snoRNPs in the absence of trimethylguanosine caps reveals nuclear cap binding protein as a gained U1 component implicated in the cold-sensitivity of tgs1Δ cellsQ35174719
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How did alternative splicing evolve?Q35930718
Rapid, transcript-specific changes in splicing in response to environmental stressQ36151037
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A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAsQ36531857
U1 small nuclear RNA from Schizosaccharomyces pombe has unique and conserved features and is encoded by an essential single-copy geneQ36710802
Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathwaysQ36968333
Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factorsQ37122051
Structure-function analysis of the Yhc1 subunit of yeast U1 snRNP and genetic interactions of Yhc1 with Mud2, Nam8, Mud1, Tgs1, U1 snRNA, SmD3 and Prp28.Q37701302
Pick one, but be quick: 5' splice sites and the problems of too many choicesQ38076663
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Cap-binding complex (CBC).Q38172648
A day in the life of the spliceosomeQ38180972
Noncanonical registers and base pairs in human 5' splice-site selectionQ38896235
Genetic and physical interactions involving the yeast nuclear cap-binding complexQ39447858
More than half of yeast U1 snRNA is dispensabel for growthQ40508912
A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5' cleavage site.Q41107145
S. cerevisiae U1 RNA is large and has limited primary sequence homology to metazoan U1 snRNA.Q41355859
Cotranscriptional spliceosome assembly dynamics and the role of U1 snRNA:5'ss base pairing in yeastQ41355869
Cryo-EM structure of a human spliceosome activated for step 2 of splicingQ41599367
Structure of a spliceosome remodelled for exon ligationQ41599374
Structure of a yeast step II catalytically activated spliceosomeQ41599632
An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28pQ41607972
Comparative analysis detects dependencies among the 5' splice-site positionsQ41807332
Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognitionQ41808431
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Dynamic regulation of alternative splicing by silencers that modulate 5' splice site competitionQ41984492
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Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotidesQ42177704
A nuclear cap binding protein complex involved in pre-mRNA splicingQ24318104
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A nuclear cap binding protein from HeLa cellsQ24595876
Early commitment of yeast pre-mRNA to the spliceosome pathwayQ24627964
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Extended base pair complementarity between U1 snRNA and the 5' splice site does not inhibit splicing in higher eukaryotes, but rather increases 5' splice site recognitionQ24812684
Crystal structure of the human nuclear cap binding complexQ27634739
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Yeast pre-mRNA splicing requires a pair of U1 snRNP-associated tetratricopeptide repeat proteinsQ27930517
A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing.Q27932647
The yeast splicing factor Mud13p is a commitment complex component and corresponds to CBP20, the small subunit of the nuclear cap-binding complexQ27933398
The yeast MUD2 protein: an interaction with PRP11 defines a bridge between commitment complexes and U2 snRNP additionQ27933542
The U1 snRNP protein U1C recognizes the 5' splice site in the absence of base pairingQ27933790
A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins.Q27934040
A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interactionQ27934198
An enhancer screen identifies a gene that encodes the yeast U1 snRNP A protein: implications for snRNP protein function in pre-mRNA splicingQ27934609
Cross-intron bridging interactions in the yeast commitment complex are conserved in mammalsQ27936705
Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognitionQ27937679
Commitment of yeast pre-mRNA to the splicing pathway requires a novel U1 small nuclear ribonucleoprotein polypeptide, Prp39pQ27938809
Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolusQ27938834
Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applicationsQ28131600
Spliceosomal UsnRNP biogenesis, structure and functionQ28188106
Spliceosome Structure and FunctionQ29392298
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Synthesis of small RNAs using T7 RNA polymeraseQ29615997
A compensatory base change in U1 snRNA suppresses a 5' splice site mutationQ29618292
Protein functions in pre-mRNA splicingQ29620262
Yeast mRNA splicing in vitroQ29620824
Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicingQ29620837
Transcript specificity in yeast pre-mRNA splicing revealed by mutations in core spliceosomal componentsQ33280145
ScreenMill: a freely available software suite for growth measurement, analysis and visualization of high-throughput screen dataQ33618530
A tradeoff drives the evolution of reduced metal resistance in natural populations of yeastQ33869677
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)9679-9693
P577publication date2017-09-01
P1433published inNucleic Acids ResearchQ135122
P1476titleThe conserved AU dinucleotide at the 5' end of nascent U1 snRNA is optimized for the interaction with nuclear cap-binding-complex
P478volume45

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