Fibroblast growth factor-2-mediated FGFR/Erk signaling supports maintenance of cancer stem-like cells in esophageal squamous cell carcinoma.

scientific article published on 13 September 2017

Fibroblast growth factor-2-mediated FGFR/Erk signaling supports maintenance of cancer stem-like cells in esophageal squamous cell carcinoma. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/CARCIN/BGX095
P932PMC publication ID5862278
P698PubMed publication ID28927233

P50authorShunsuke OhnishiQ42727592
Mitsuteru NatsuizakaQ57050691
Naoya SakamotoQ89436415
P2093author name stringKenichi Morikawa
Seiji Naganuma
Hiroshi Nakagawa
Hiroshi Takeda
Shinya Ohashi
Yoshito Komatsu
Masato Nakai
Koji Nakagawa
Hideaki Kinugasa
Fumiyuki Sato
Goki Suda
Koji Ogawa
Megumi Kimura
Takuya Sho
Shingo Kagawa
Osamu Maehara
Tomoe Shimazaki
Kelly A Whelan
Yoshiyuki Fujimoto
Ayaka Asano
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hypoxia-inducible factors activate CD133 promoter through ETS family transcription factors.Q34805209
Fibroblast growth factors: from molecular evolution to roles in development, metabolism and diseaseQ35020888
Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistanceQ35816889
Outcomes from a prospective trial of endoscopic radiofrequency ablation of early squamous cell neoplasia of the esophagusQ36419431
Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell PopulationQ36471425
Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutationQ36734197
Enhanced Expression of Fibroblast Growth Factor Receptor 3 IIIc Promotes Human Esophageal Carcinoma Cell ProliferationQ36737108
FGFR1 promotes the stem cell-like phenotype of FGFR1-amplified non-small cell lung cancer cells through the Hedgehog pathwayQ37046814
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IGFBP3 promotes esophageal cancer growth by suppressing oxidative stress in hypoxic tumor microenvironmentQ37516299
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Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markersQ38396653
Cancer stem cells in oesophageal squamous cell carcinoma: Identification, prognostic and treatment perspectivesQ38443189
NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microenvironment of esophageal cancer regulates the survival and migration of tumor-associated macrophages and cancer cells.Q38763653
Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinomaQ38812372
Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF.Q38843112
EGFR inhibitors prevent induction of cancer stem-like cells in esophageal squamous cell carcinoma by suppressing epithelial-mesenchymal transitionQ38883950
A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors.Q38905550
Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expressionQ38912201
AKT/GSK-3β regulates stability and transcription of snail which is crucial for bFGF-induced epithelial-mesenchymal transition of prostate cancer cellsQ38969060
Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras.Q40213134
Basic fibroblast growth factor (FGF-2) overexpression is a risk factor for esophageal cancer recurrence and reduced survival, which is ameliorated by coexpression of the FGF-2 antisense gene.Q40353020
Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factorsQ41376475
Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma.Q42028034
Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities.Q42040176
Endoscopic submucosal dissection of early esophageal cancer.Q51404433
Long-term outcome after endoscopic mucosal resection in patients with esophageal squamous cell carcinoma invading the muscularis mucosae or deeperQ74662163
Tyrosine kinases as targets for cancer therapyQ80367757
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectesophageal squamous cell carcinomaQ108442577
P304page(s)1073-1083
P577publication date2017-10-01
P1433published inCarcinogenesisQ326022
P1476titleFibroblast growth factor-2-mediated FGFR/Erk signaling supports maintenance of cancer stem-like cells in esophageal squamous cell carcinoma
P478volume38

Reverse relations

cites work (P2860)
Q96817058CDK5RAP3 as tumour suppressor negatively regulates self-renewal and invasion and is regulated by ERK1/2 signalling in human gastric cancer
Q98906651FGF/FGFR signaling in health and disease
Q64951868FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p.
Q88955678FGFR1-ERK1/2-SOX2 axis promotes cell proliferation, epithelial-mesenchymal transition, and metastasis in FGFR1-amplified lung cancer
Q91596559Function of fibroblast growth factor 2 in gastric cancer occurrence and prognosis
Q93143116Identification of microRNAs as novel biomarkers for esophageal squamous cell carcinoma: a study based on The Cancer Genome Atlas (TCGA) and bioinformatics
Q93078789Long Pentraxin-3 Follows and Modulates Bladder Cancer Progression
Q64083249Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines
Q93252546New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer
Q91695602Shisa3 brakes resistance to EGFR-TKIs in lung adenocarcinoma by suppressing cancer stem cell properties
Q64054193Targeting p21-activated kinase 1 inhibits growth and metastasis via Raf1/MEK1/ERK signaling in esophageal squamous cell carcinoma cells
Q93021945The Role of Fgf Signaling on Epithelial Cell Differentiation in Mouse Vagina
Q89746470The paradox of cancer genes in non-malignant conditions: implications for precision medicine
Q90028633p300 Acetyltransferase Is a Cytoplasm-to-Nucleus Shuttle for SMAD2/3 and TAZ Nuclear Transport in Transforming Growth Factor β-Stimulated Hepatic Stellate Cells

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