Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma

scientific article published on 11 December 2015

Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1136/GUTJNL-2015-309501
P932PMC publication ID5600200
P698PubMed publication ID26658144

P50authorChristele Desbois-MouthonQ58392320
Agrin MoeiniQ60674768
Juan J LozanoQ61297522
Josep M. LlovetQ37393125
Augusto VillanuevaQ56754203
P2093author name stringYujin Hoshida
Clara Alsinet
Daniela Sia
Helena Cornella
Iris Martinez-Quetglas
Manel Solé
Sara Torrecilla
Victoria Tovar
Josep Domingo-Domenech
Laia Cabellos
Judit Peix
Samuel Vidal
P2860cites workHepatic Stem-like Phenotype and Interplay of Wnt/β-Catenin and Myc Signaling in Aggressive Childhood Liver CancerQ56762983
Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinibQ80307760
Improved survival with vemurafenib in melanoma with BRAF V600E mutationQ24631953
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domainQ24794765
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Sorafenib in advanced hepatocellular carcinomaQ27861075
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3KQ29614757
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemiaQ29615030
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplificationQ29618788
Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinomaQ33820376
IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage.Q34102411
Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivoQ34268708
Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinomaQ34842280
The Enhanced metastatic potential of hepatocellular carcinoma (HCC) cells with sorafenib resistanceQ35045419
In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.Q35250612
Insulin-like growth factor (IGF) signaling in tumorigenesis and the development of cancer drug resistanceQ35606589
Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinomaQ36547263
Cancer stem cells in the development of liver cancerQ36793453
Focal gains of VEGFA and molecular classification of hepatocellular carcinomaQ36984575
Pivotal role of mTOR signaling in hepatocellular carcinomaQ37183244
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibitionQ37331610
Targeting cancer stem cells to suppress acquired chemotherapy resistanceQ38149736
Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinoma.Q38175454
Transcriptome classification of HCC is related to gene alterations and to new therapeutic targetsQ38400913
ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitorsQ38947384
Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma.Q39214063
EGFR activation is a potential determinant of primary resistance of hepatocellular carcinoma cells to sorafenibQ39362619
Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cellsQ39612275
EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinomaQ40006245
Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinomaQ41918713
Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinomaQ44811513
DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma.Q51499838
Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells.Q53179931
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecthepatocellular carcinomaQ1148337
P304page(s)530-540
P577publication date2015-12-11
P1433published inGutQ5621669
P1476titleTumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma
P478volume66

Reverse relations

cites work (P2860)
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