Hedgehog signaling promotes sorafenib resistance in hepatocellular carcinoma patient-derived organoids

scientific article published on 28 January 2020

Hedgehog signaling promotes sorafenib resistance in hepatocellular carcinoma patient-derived organoids is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1186/S13046-020-1523-2
P932PMC publication ID6986013
P698PubMed publication ID31992334

P2093author name stringQian Cheng
Yang Wang
Siqi Wang
Zhao Li
Xiao Xiang
Jiye Zhu
Changkun Zhang
Shihua Hu
Xiaodong Xun
P2860cites workModeling Development and Disease with OrganoidsQ24657457
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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplificationQ29618788
Organoid cultures derived from patients with advanced prostate cancerQ34545103
A miRNA signature of chemoresistant mesenchymal phenotype identifies novel molecular targets associated with advanced pancreatic cancerQ35237480
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicityQ35757997
Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cellsQ36997036
Cancer stem cells: implications for the progression and treatment of metastatic disease.Q37053174
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibitionQ37331610
Prognostic value of the expression of cancer stem cell-related markers CD133 and CD44 in hepatocellular carcinoma: From patients to patient-derived tumor xenograft modelsQ37565162
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Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathwaysQ37820099
Control of stem cells and cancer stem cells by Hedgehog signaling: pharmacologic clues from pathway dissectionQ38059538
Targeting cancer stem cells to suppress acquired chemotherapy resistanceQ38149736
Antagonism of EGFR and Notch limits resistance to EGFR inhibitors and radiation by decreasing tumor-initiating cell frequency.Q38713045
Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinomaQ38812372
High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.Q38826826
Aberrant hedgehog signaling is responsible for the highly invasive behavior of a subpopulation of hepatoma cells.Q38899847
ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitorsQ38947384
Implication of the Hedgehog pathway in hepatocellular carcinoma.Q39433923
Hepatitis B virus X protein stimulates the Hedgehog-Gli activation through protein stabilization and nuclear localization of Gli1 in liver cancer cellsQ39512904
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunityQ40944056
Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E.Q43996886
Dysregulation of the Hedgehog pathway in human hepatocarcinogenesisQ46843790
Human primary liver cancer-derived organoid cultures for disease modeling and drug screeningQ48317424
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.Q48574942
Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trialQ50046367
MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function.Q52584558
Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer.Q52602391
Galunisertib suppresses the staminal phenotype in hepatocellular carcinoma by modulating CD44 expression.Q52668585
The biology and role of CD44 in cancer progression: therapeutic implications.Q54110894
Activation of the hedgehog pathway in human hepatocellular carcinomas.Q54616323
Hepatocellular carcinomaQ58020832
Organoid Models of Human Liver Cancers Derived from Tumor Needle BiopsiesQ58450461
Intra-tumour diversification in colorectal cancer at the single-cell levelQ59064996
The molecular connection of histopathological heterogeneity in hepatocellular carcinoma: A role of Wnt and Hedgehog signaling pathwaysQ60047391
CD44 standard isoform is involved in maintenance of cancer stem cells of a hepatocellular carcinoma cell lineQ64262837
Cancer modeling meets human organoid technologyQ69497099
Stem cell fate in cancer growth, progression and therapy resistanceQ91518791
Silencing of the MEKK2/MEKK3 Pathway Protects against Spinal Cord Injury via the Hedgehog Pathway and the JNK PathwayQ92419809
Hepatocellular CarcinomaQ93002915
P433issue1
P921main subjecthepatocellular carcinomaQ1148337
organoidQ11293125
P304page(s)22
P577publication date2020-01-28
P1433published inJournal of Experimental & Clinical Cancer ResearchQ13739415
P1476titleHedgehog signaling promotes sorafenib resistance in hepatocellular carcinoma patient-derived organoids
P478volume39

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