Mepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype, in Asthma.

scientific article published in September 2017

Mepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype, in Asthma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1164/RCCM.201611-2234OC
P932PMC publication ID5736971
P698PubMed publication ID28862877

P50authorElizabeth A KellyQ55094086
Mats W. JohanssonQ55094089
Nizar N JarjourQ88330675
Sameer MathurQ88895109
Stephane EsnaultQ42777061
Michael D. EvansQ43090931
P2093author name stringDeane F Mosher
Loren C Denlinger
Lin Ying Liu
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Increased airway inflammation with segmental versus aerosol antigen challengeQ70457990
Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthmaQ73728083
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Human airway and peripheral blood eosinophils enhance Th1 and Th2 cytokine secretionQ83185052
Theirs but to die and do: primary lysis of eosinophils and free eosinophil granules in asthmaQ87262417
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Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levelsQ37358879
Haemopoietic processes in allergic disease: eosinophil/basophil developmentQ37557714
Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokinesQ37625993
Mepolizumab and exacerbations of refractory eosinophilic asthmaQ37711391
Pharmacokinetics and pharmacodynamics of mepolizumab, an anti-interleukin-5 monoclonal antibodyQ37846670
Eosinophil granule proteins: form and functionQ38209847
In situ hematopoiesis: a regulator of TH2 cytokine-mediated immunity and inflammation at mucosal surfacesQ38382162
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CD44 and CD69 represent different types of cell-surface activation markers for human eosinophilsQ41031721
Potent synergistic effect of IL-3 and TNF on matrix metalloproteinase 9 generation by human eosinophilsQ41909413
Human airway smooth muscle promotes eosinophil differentiationQ42170514
RNA Seq profiling reveals a novel expression pattern of TGF-β target genes in human blood eosinophils.Q42776997
The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjectsQ44058571
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Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.Q44247874
Differential regulation of human eosinophil IL-3, IL-5, and GM-CSF receptor alpha-chain expression by cytokines: IL-3, IL-5, and GM-CSF down-regulate IL-5 receptor alpha expression with loss of IL-5 responsiveness, but up-regulate IL-3 receptor alphQ44448872
Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthmaQ44715380
Local proliferation and mobilization of CCR3(+)  CD34(+) eosinophil-lineage-committed cells in the lungQ45350681
Mepolizumab for prednisone-dependent asthma with sputum eosinophiliaQ46098864
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectasthmaQ35869
phenotypeQ104053
mepolizumabQ3306175
P304page(s)1385-1395
P577publication date2017-12-01
P1433published inAmerican Journal of Respiratory and Critical Care MedicineQ4744267
P1476titleMepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype, in Asthma
P478volume196

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