Assessing the evidence for shared genetic risks across psychiatric disorders and traits

scientific article

Assessing the evidence for shared genetic risks across psychiatric disorders and traits is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1017/S0033291717003440
P932PMC publication ID6088770
P698PubMed publication ID29198204

P50authorPaul LichtensteinQ56460588
Joanna MartinQ57061991
P2093author name stringMark J Taylor
P2860cites workPartitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architectureQ21090200
Rare chromosomal deletions and duplications increase risk of schizophreniaQ22337245
Functional impact of global rare copy number variation in autism spectrum disordersQ24596191
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysisQ24597718
Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardationQ24629022
A twin study of genetic relationships between psychotic symptomsQ28211685
Common polygenic variation contributes to risk of schizophrenia and bipolar disorderQ28250609
Synaptic, transcriptional and chromatin genes disrupted in autismQ28250800
The contribution of de novo coding mutations to autism spectrum disorderQ28250812
Meta-analysis of the heritability of human traits based on fifty years of twin studiesQ28262090
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPsQ28296286
Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with AutismQ29013643
A framework for the interpretation of de novo mutation in human diseaseQ29031873
GCTA: a tool for genome-wide complex trait analysisQ29547216
A copy number variation morbidity map of developmental delayQ29616033
Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortiaQ30275693
A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseasesQ30276804
Fears and fearfulness in children and adolescents: a genetic analysis of twin dataQ30859272
Association between polygenic risk scores for attention-deficit hyperactivity disorder and educational and cognitive outcomes in the general populationQ33654094
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophreniaQ33717278
Evidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twinsQ33736572
Characterization of psychotic experiences in adolescence using the specific psychotic experiences questionnaire: findings from a study of 5000 16-year-old twins.Q33762519
Genetic architectures of psychiatric disorders: the emerging picture and its implicationsQ33949729
Bipolar disorder and its relation to major psychiatric disorders: a family-based study in the Swedish populationQ48234415
Autistic-like traits and their association with mental health problems in two nationwide twin cohorts of children and adultsQ48887762
Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD.Q48954065
Association of autistic-like and internalizing traits during childhood: a longitudinal twin studyQ50303776
Developmental associations between traits of autism spectrum disorder and attention deficit hyperactivity disorder: a genetically informative, longitudinal twin studyQ50303881
Association between extreme autistic traits and intellectual disability: insights from a general population twin studyQ50305882
Language and mathematical problems as precursors of psychotic-like experiences and juvenile mania symptoms.Q50695837
Depressive symptoms in children and adolescents: etiological links between normality and abnormality: a research note.Q50925412
Genetic and environmental influences on disordered eating and depressive symptoms.Q51000685
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.Q52560096
Genetic and environmental contributions to the association between ADHD and affective problems in early childhood-A Swedish population-based twin studyQ40230678
An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression PhenotypeQ40397660
High loading of polygenic risk in cases with chronic schizophreniaQ40589507
Understanding the covariation of tics, attention-deficit/hyperactivity, and obsessive-compulsive symptoms: A population-based adult twin studyQ40885070
Genetic and environmental influences on the relationship between ADHD symptoms and internalizing problems: A Chinese twin studyQ41016361
Aetiological overlap between obsessive-compulsive related and anxiety disorder symptoms: multivariate twin study.Q41192111
Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish populationQ41455877
The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhoodQ42670854
Polygenic risk for schizophrenia is associated with cognitive change between childhood and old age.Q44592961
The sources of co-morbidity between major depression and generalized anxiety disorder in a Swedish national twin sampleQ44924966
Autism spectrum disorders and autistic like traits: similar etiology in the extreme end and the normal variationQ45010374
A twin study of generalized anxiety disorder and major depression.Q45095951
Klinefelter syndrome and risk of psychosis, autism and ADHD.Q45160205
Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sampleQ45232519
Comorbidity: a network perspective.Q45241713
Symptoms of autism and ADHD: a Swedish twin study examining their overlapQ45734606
Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairsQ46251837
Large-scale discovery of novel genetic causes of developmental disordersQ47073693
Single Nucleotide Polymorphism Heritability of a General Psychopathology Factor in ChildrenQ47626125
Substantial genetic influence on mild mental impairment in early childhoodQ48128339
Autism spectrum disorders and autistic traits share genetics and biologyQ48141649
Aetiological overlap between anxiety and attention deficit hyperactivity symptom dimensions in adolescence.Q48218376
Common disorders are quantitative traitsQ57278014
Genetic and Environmental Influences on Depressive Symptomatology in Adolescence: Individual Differences and Extreme ScoresQ57278190
Autism spectrum disorders and autistic traits share genetics and biologyQ57307153
The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathologyQ57697433
Neurodevelopmental disordersQ60365498
Anxiety and Depressive Symptoms in Childhood?A Genetic Study of ComorbidityQ61478567
Twin Studies on Obsessive–Compulsive Disorder: A ReviewQ62089459
Attention-deficit hyperactivity disorder: a category or a continuum? Genetic analysis of a large-scale twin studyQ73414645
Are your covariates under control? How normalization can re-introduce covariate effectsQ88506822
Cognitive Performance Among Carriers of Pathogenic Copy Number Variants: Analysis of 152,000 UK Biobank SubjectsQ39257462
Different neurodevelopmental symptoms have a common genetic etiologyQ39332470
Limited genetic covariance between autistic traits and intelligence: findings from a longitudinal twin studyQ39899950
Genetic overlap between measures of hyperactivity/inattention and mood in children and adolescentsQ39942264
Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligenceQ40191170
Is there a general factor of prevalent psychopathology during adulthood?Q34051685
Relative burden of large CNVs on a range of neurodevelopmental phenotypesQ34079175
Linking temperamental fearfulness and anxiety symptoms: a behavior-genetic perspectiveQ34117527
Consistent etiology of severe, frequent psychotic experiences and milder, less frequent manifestations: a twin study of specific psychotic experiences in adolescence.Q34142822
Multiple regression analysis of twin dataQ34201171
Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysisQ34247422
Genetic risk for attention-deficit/hyperactivity disorder contributes to neurodevelopmental traits in the general populationQ34281462
A population-based study of genetic variation and psychotic experiences in adolescentsQ34322883
The p Factor: One General Psychopathology Factor in the Structure of Psychiatric Disorders?Q34404372
Research review: Polygenic methods and their application to psychiatric traitsQ34434004
Genetic Overlap between ADHD Symptoms and Reading is largely Driven by Inattentiveness rather than Hyperactivity-Impulsivity.Q34509182
Genetic and environmental influences on the co-morbidity between depression, panic disorder, agoraphobia, and social phobia: a twin studyQ34557801
Thinking positively: The genetics of high intelligenceQ34862561
Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based studyQ34923924
Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorderQ35059381
Genetic risk profiles for depression and anxiety in adult and elderly cohortsQ35126132
Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence?Q35144308
Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD.Q35241258
Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorderQ35606173
LD Score regression distinguishes confounding from polygenicity in genome-wide association studiesQ35831121
Rare structural variants in schizophrenia: one disorder, multiple mutations; one mutation, multiple disordersQ35956872
Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypesQ35969053
Etiological overlap between obsessive-compulsive disorder and anorexia nervosa: a longitudinal cohort, multigenerational family and twin studyQ36118730
Partitioning heritability by functional annotation using genome-wide association summary statisticsQ36225291
Twin studies on obsessive-compulsive disorder: a reviewQ36280479
Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihoodQ36294045
Genetic research in autism spectrum disordersQ36294587
Copy number variations and cognitive phenotypes in unselected populationsQ36384798
The Colorado Longitudinal Twin Study of Reading Difficulties and ADHD: Etiologies of Comorbidity and StabilityQ36386415
Heritability of Autism Spectrum Disorder in a UK Population-Based Twin SampleQ36496187
Discontinuity in the genetic and environmental causes of the intellectual disability spectrumQ36551517
Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general populationQ36594747
Phenome-wide analysis of genome-wide polygenic scores.Q36619995
The opposite end of the attention deficit hyperactivity disorder continuum: genetic and environmental aetiologies of extremely low ADHD traitsQ36679960
Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3.Q36695755
An atlas of genetic correlations across human diseases and traitsQ36701237
Evidence of Common Genetic Overlap Between Schizophrenia and Cognition.Q36817198
Obsessive-compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs.Q36915446
Evidence that autistic traits show the same etiology in the general population and at the quantitative extremes (5%, 2.5%, and 1%)Q37003056
Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophreniaQ37061218
Meta-analysis of genome-wide association studies of anxiety disorders.Q37083693
Distribution of disease-associated copy number variants across distinct disorders of cognitive developmentQ37174458
Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general populationQ37177974
Shared Etiology of Psychotic Experiences and Depressive Symptoms in Adolescence: A Longitudinal Twin Study.Q37183961
Phenotypic Manifestation of Genetic Risk for Schizophrenia During Adolescence in the General PopulationQ37258886
Heritability across the distribution: an application of quantile regressionQ37265061
A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric CohortsQ37347399
Patterns of Nonrandom Mating Within and Across 11 Major Psychiatric DisordersQ37371928
Evidence for shared genetic risk between ADHD symptoms and reduced mathematics ability: a twin studyQ37397137
Molecular validation of the schizophrenia spectrum.Q37451517
Detection and interpretation of shared genetic influences on 42 human traitsQ37552665
Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disordersQ37613249
Common disorders are quantitative traitsQ37622048
Aetiological overlap between obsessive-compulsive and depressive symptoms: a longitudinal twin study in adolescents and adults.Q37646506
Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT).Q37670805
A Cross-Disorder Method to Identify Novel Candidate Genes for Developmental Brain DisordersQ37676902
ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficultiesQ37739910
Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010.Q38133045
Concepts, estimation and interpretation of SNP-based heritabilityQ38602229
Polygenic scores for schizophrenia and educational attainment are associated with behavioural problems in early childhood in the general population.Q38719516
Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders.Q38786077
Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development.Q38845234
Genetic Overlap Between Schizophrenia and Developmental Psychopathology: Longitudinal and Multivariate Polygenic Risk Prediction of Common Psychiatric Traits During DevelopmentQ38879526
Schizophrenia risk alleles and neurodevelopmental outcomes in childhood: a population-based cohort studyQ39118252
Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of childrenQ39125071
Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis.Q39150835
Association of Genetic Risk Variants With Attention-Deficit/Hyperactivity Disorder Trajectories in the General Population.Q39223758
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectgenome-wide association studyQ1098876
mental disorderQ12135
genetic predisposition to diseaseQ64843122
biomedical investigative techniqueQ66648976
multifactorial inheritanceQ67200773
P304page(s)1-16
P577publication date2017-12-04
2018-08-01
P1433published inPsychological MedicineQ7256364
P1476titleAssessing the evidence for shared genetic risks across psychiatric disorders and traits

Reverse relations

cites work (P2860)
Q61852287Association of Genetic Risk Factors for Psychiatric Disorders and Traits of These Disorders in a Swedish Population Twin Sample.
Q64075928Association of Maternal Neurodevelopmental Risk Alleles With Early-Life Exposures
Q92017843Association of etiological factors across the extreme end and continuous variation in disordered eating in female Swedish twins
Q57279532Copy number variation and neuropsychiatric problems in females and males in the general population
Q92555462Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders
Q97680136Early environmental risk factors for neurodevelopmental disorders - a systematic review of twin and sibling studies
Q101216820Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits
Q97420453Family Environment, Neurodevelopmental Risk, and the Environmental Influences on Child Health Outcomes (ECHO) Initiative: Looking Back and Moving Forward
Q57159824Genetic and environmental contribution to the overlap between ADHD and ASD trait dimensions in young adults: a twin study
Q90973869Genetic and environmental contributions to diagnostic fluctuation in anorexia nervosa and bulimia nervosa
Q93153600Genetic influences on treatment-seeking for common mental health problems in the UK biobank
Q91013648Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.
Q93135022Identifying Novel Types of Irritability Using a Developmental Genetic Approach
Q93144435Internalizing and externalizing psychopathology in middle age: genetic and environmental architecture and stability of symptoms over 15 to 20 years
Q91218920Reasoning bias, working memory performance and a transdiagnostic phenotype of affective disturbances and psychotic experiences in the general population
Q91714868Redefining phenotypes to advance psychiatric genetics: Implications from hierarchical taxonomy of psychopathology
Q90319220Shared Genetics of Psychiatric Disorders
Q90453875Shared molecular genetic risk of alcohol dependence and posttraumatic stress disorder (PTSD)
Q57697433The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathology
Q92783327The importance of a developmental perspective in Psychiatry: what do recent genetic-epidemiological findings show?
Q60619265Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Q90324756Unraveling the genetic architecture of major depressive disorder: merits and pitfalls of the approaches used in genome-wide association studies
Q100954433Violence and mental disorders: a structured review of associations by individual diagnoses, risk factors, and risk assessment
Q89534692Volitional eye movement control and ADHD traits: a twin study

Search more.