Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats

scientific article published in May 1998

Prolonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0042-6989(97)00341-6
P698PubMed publication ID9667016

P2093author name stringD B Clarke
A J Aguayo
G M Bray
P2860cites workInjury-induced upregulation of bFGF and CNTF mRNAS in the rat retinaQ71511587
Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic miceQ71784054
Quantitative comparison of the transient rescue effects of neurotrophic factors on axotomized motoneurons in vivoQ72145001
Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cellsQ35063857
Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cellsQ36014895
Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificityQ36935698
Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transectionQ37410352
Trophic factors and neuronal survivalQ38772889
The trkB tyrosine protein kinase is a receptor for neurotrophin-4Q41626768
Neurotrophin-5: A novel neurotrophic factor that activates trk and trkBQ41658559
p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGFQ42458990
Nerve growth factor induces trkA mRNA expression in cultured basal forebrain cholinergic neurons from 17-day fetal ratsQ42496032
Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administrationQ42496429
Down-regulation of phosphatidylinositol response to BDNF and NT-3 in cultures of cortical neuronsQ46073764
Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in cultureQ46084557
Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neuronsQ46312267
Ligand-induced down-regulation of Trk messenger RNA, protein and tyrosine phosphorylation in rat cortical neuronsQ46976249
Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats.Q48093574
Long-term growth and remodeling of regenerated retino-collicular connections in adult hamsters.Q48187437
Fluoro-Gold: a new fluorescent retrograde axonal tracer with numerous unique propertiesQ48322941
Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivoQ48333202
Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult ratsQ48364946
Loss of AChE- and NGFr-labeling precedes neuronal death of axotomized septal-diagonal band neurons: reversal by intraventricular NGF infusionQ48681099
Different forms of the neurotrophin receptor trkB mRNA predominate in rat retina and optic nerve.Q55482714
Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult ratsQ69016395
Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatmentQ69835826
At least two mechanisms are involved in the death of retinal ganglion cells following target ablation in neonatal ratsQ71038751
Neurotrophin-4/5 postpones the death of injured spinal motoneurons in newborn ratsQ71066261
BDNF down-regulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neuronsQ71383353
P433issue10
P921main subjectretinal ganglion cellQ927337
P304page(s)1517-1524
P577publication date1998-05-01
P1433published inVision ResearchQ1307852
P1476titleProlonged administration of NT-4/5 fails to rescue most axotomized retinal ganglion cells in adult rats
P478volume38

Reverse relations

cites work (P2860)
Q44283542Administration of brain-derived neurotrophic factor suppresses the expression of heat shock protein 27 in rat retinal ganglion cells following axotomy
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Q24657994Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma
Q92380800Increased levels of synaptic proteins involved in synaptic plasticity after chronic intraocular pressure elevation and modulation by brain-derived neurotrophic factor in a glaucoma animal model
Q43948430Injury to retinal ganglion cells induces expression of the small heat shock protein Hsp27 in the rat visual system
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