The Human Serotonin Type 3 Receptor Gene (HTR3A-E) Allelic Variant Database

scientific article published on 20 October 2016

The Human Serotonin Type 3 Receptor Gene (HTR3A-E) Allelic Variant Database is …
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scholarly articleQ13442814

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P356DOI10.1002/HUMU.23136
P698PubMed publication ID27763704

P2093author name stringJacopo Celli
Gudrun Rappold
Beate Niesler
P2860cites workThe 5-HT3B subunit is a major determinant of serotonin-receptor functionQ22001471
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HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power--an intermediate phenotype for alcoholism and co-morbid behaviorsQ24643891
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The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunitQ28145907
5-HT(3)-receptor antagonists in the management of nausea and vomiting in cancer and cancer treatmentQ28269736
Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependenceQ30410433
Physiogenomic analysis of localized FMRI brain activity in schizophreniaQ30490136
Serotonin receptor gene HTR3A variants in schizophrenic and bipolar affective patientsQ32022721
Laser microdissection as a new tool to investigate site-specific gene expression in enteric ganglia of the human intestineQ33513286
Genetic, psychosocial, and demographic factors associated with social disinhibition in Mexican-origin youthQ34025037
LOVD v.2.0: the next generation in gene variant databasesQ34180504
Gut feelings: the emerging biology of gut-brain communicationQ34199959
Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E.Q34205102
A cluster of novel serotonin receptor 3-like genes on human chromosome 3.Q34274273
Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonistsQ34317254
Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependenceQ34414342
Allosteric activation of the 5-HT3AB receptor by mCPBG.Q34455739
Association between the 5' UTR variant C178T of the serotonin receptor gene HTR3A and bipolar affective disorderQ34517004
Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients.Q34552006
Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine.Q34570087
Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.Q34667005
Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapyQ34767999
Pharmacogenetic predictors of nausea and vomiting of pregnancy severity and response to antiemetic therapy: a pilot studyQ34779394
First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndromeQ34794063
Hyperemesis gravidarumQ34818086
Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorderQ34871885
Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling.Q34880257
Association between a polymorphism of the HTR3A gene and therapeutic response to risperidone treatment in drug-naive Chinese schizophrenia patientsQ46486910
A variant C178T in the regulatory region of the serotonin receptor gene HTR3A modulates neural activation in the human amygdala.Q46586690
Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depressionQ46951820
The effect of 5-hydroxytryptamine 3A and 3B receptor genes on nausea induced by paroxetineQ46988894
Sequence variants of the HTR3A gene contribute to the genetic prediction of postoperative nausea in TaiwanQ47796943
5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option.Q47825625
New treatment options using 5-HT3 receptor antagonists in rheumatic diseasesQ48656867
Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response.Q50786215
Natural compounds boldine and menthol are antagonists of human 5-HT3receptors: implications for treating gastrointestinal disordersQ56971318
Identification of 5-HT3 receptors on human platelets: Increased surface immunoreactivity after activation with adenosine diphosphate (ADP) and thrombin receptor-activating peptide (TRAP)Q61883425
Anticancer drug irinotecan inhibits homomeric 5-HT3A and heteromeric 5-HT3AB receptor responsesQ82295345
Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neuronsQ86380488
5-HT3-receptor antagonists and the cytochrome P450 system: clinical implicationsQ34989289
Varenicline is a potent agonist of the human 5-hydroxytryptamine3 receptor.Q35265605
Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsiaQ35541477
The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphineQ35859775
Influence of the 5-HT3A Receptor Gene Polymorphism and Childhood Sexual Trauma on Central Serotonin ActivityQ35877769
VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptorsQ35913156
Replication of functional serotonin receptor type 3A and B variants in bipolar affective disorder: a European multicenter studyQ35913898
HGVS Recommendations for the Description of Sequence Variants: 2016 UpdateQ35941614
Association of 5-HT3B Receptor Gene Polymorphisms with the Efficacy of Ondansetron for Postoperative Nausea and Vomiting.Q35971173
Association of the Serotonin Receptor 3E Gene as a Functional Variant in the MicroRNA-510 Target Site with Diarrhea Predominant Irritable Bowel Syndrome in Chinese WomenQ36762657
Serotonin homeostasis and serotonin receptors as actors of cortical construction: special attention to the 5-HT3A and 5-HT6 receptor subtypesQ36939119
Characterization of 5-HT3 receptor mutations identified in schizophrenic patientsQ37112926
The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndromeQ37134075
Allelic variants in HTR3C show association with autism.Q37245358
Heroin addiction in African Americans: a hypothesis-driven association studyQ37276058
Polymorphism in serotonin receptor 3B is associated with pain catastrophizingQ37297649
Discriminating between 5-HT₃A and 5-HT₃AB receptorsQ38089188
Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophreniaQ39602459
Discovery of a Novel 5-HT3 Antagonist/5-HT1A Agonist 3-Amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an Orally Bioavailable Agent for Irritable Bowel SyndromeQ39646786
Characterization of the naturally occurring Arg344His variant of the human 5-HT 3A receptorQ39776432
Early life stress combined with serotonin 3A receptor and brain-derived neurotrophic factor valine 66 to methionine genotypes impacts emotional brain and arousal correlates of risk for depressionQ39845321
5-HT(3) receptors: role in disease and target of drugsQ39858435
Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function.Q39916125
Identification of 5-HT3A and 5-HT3B receptor subunits in human hippocampusQ40165806
Serotonin excites neurons in the human submucous plexus via 5-HT3 receptorsQ40424072
Evidence for schizophrenia susceptibility alleles in the Indian population: An association of neurodevelopmental genes in case-control and familial samplesQ41595398
Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed moodQ42942964
Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapyQ42985583
A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patientsQ43113117
Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancyQ43215450
Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophreniaQ43268912
Functional variants of the serotonin receptor type 3A and B gene are associated with eating disordersQ43278805
Do variations in the 5-HT3A and 5-HT3B serotonin receptor genes (HTR3A and HTR3B) influence the occurrence of postoperative vomiting?Q43284597
Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptorsQ43698616
Variations in the 5-hydroxytryptamine type 3B receptor gene as predictors of the efficacy of antiemetic treatment in cancer patientsQ44459255
A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in womenQ44616207
Pharmacological and electrophysiological properties of the naturally occurring Pro391Arg variant of the human 5-HT3A receptorQ44914015
The safety of ondansetron for nausea and vomiting of pregnancy: a prospective comparative studyQ45029089
Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patientsQ45076450
Concluding remarks and outlook for the use of 5-HT3 receptor antagonists in rheumatology.Q45130908
P433issue2
P304page(s)137-147
P577publication date2016-10-20
P1433published inHuman MutationQ5937269
P1476titleThe Human Serotonin Type 3 Receptor Gene (HTR3A-E) Allelic Variant Database
P478volume38

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Q38661352Pharmacogenetics and the treatment of functional gastrointestinal disorderscites workP2860

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