Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance

scientific article published in June 1998

Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S0140-6736(98)03391-1
P8608Fatcat IDrelease_cvq7l5mqyfbarol3oz7vnbhiuq
P698PubMed publication ID9652687

P2093author name stringA Carr
D J Chisholm
D A Cooper
K Samaras
P2860cites workThe LDL-receptor-related protein, LRP, is an apolipoprotein E-binding proteinQ24339570
Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1Q27702268
Crystal structure of cellular retinoic acid binding protein I shows increased access to the binding cavity due to formation of an intermolecular beta-sheetQ27729587
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitusQ28190307
Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonistQ28286186
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factorQ29547912
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gammaQ29615221
Retinoic acid biosynthesis and metabolismQ34063235
Hypertrophy of the breasts in a patient treated with indinavirQ34444998
Effects of nonesterified fatty acid availability on tissue-specific glucose utilization in rats in vivoQ34557980
Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.Q37376673
Structure/function of cytoplasmic vitamin A-binding proteins.Q41138378
Regulation of metabolism by retinoic acid and its nuclear receptorsQ41138384
A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitorsQ43613003
Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonistsQ46221014
"Buffalo hump" in men with HIV-1 infection.Q51571024
Indinavir-associated lipodystrophy.Q54138768
The non-genetic determinants of central adiposity*Q57258093
Regulation of adipose cell number in manQ73085437
Visceral abdominal-fat accumulation associated with use of indinavirQ74390712
HIV-1 protease inhibitorsQ95819985
P433issue9119
P407language of work or nameEnglishQ1860
P921main subjectHIVQ15787
insulin resistanceQ1053470
hyperlipidemiaQ1079120
preproinsulinQ7240673
P304page(s)1881-1883
P577publication date1998-06-01
P1433published inThe LancetQ939416
P1476titlePathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance
P478volume351

Reverse relations

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Q45285373Mitochondrial involvement in antiretroviral therapy-related lipodystrophy of HIV-infected patients
Q33745859Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy
Q37736324Modern trends in lipomodeling
Q44499492Modulation of the LDL receptor and LRP levels by HIV protease inhibitors
Q34207689Molecular basis of partial lipodystrophy and prospects for therapy
Q36211491Molecular mechanisms of HIV-1 associated neurodegeneration
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Q34050577Morphogenesis of the developing mammary gland: stage-dependent impact of adipocytes.
Q45739840Multiple circumscribed subcutaneous lipomas associated with use of human immunodeficiency virus protease inhibitors?
Q33592439Nelfinavir mesylate: a protease inhibitor
Q44724352Nevirapine plus efavirenz plus didanosine: a simple, safe, and effective once-daily regimen for patients with HIV infection.
Q37271807New options in the treatment of lipid disorders in HIV-infected patients
Q33706638New-onset diabetes mellitus associated with protease inhibitor therapy in an HIV-positive patient: case report and review.
Q30251861Novel functions of PXR in cardiometabolic disease
Q34906959Novel strategies for targeting the dimerization interface of HIV protease with cross-linked interfacial peptides
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Q33798985Nutrition and immune function in human immunodeficiency virus infection.
Q38061798Nutrition and the HIV-associated lipodystrophy syndrome
Q33927664Nutrition in paediatric human immunodeficiency virus infection
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Q42125460Paracardial lipodystrophy versus pericardial effusion in HIV positive patients
Q73953962Partial lipodystrophy, polycystic ovary syndrome and proteinuria: a common link to insulin resistance?
Q34547836Pathogenesis of HIV-associated cardiovascular complications
Q35193326Peripheral and central fat changes in subjects randomized to abacavir-lamivudine or tenofovir-emtricitabine with atazanavir-ritonavir or efavirenz: ACTG Study A5224s
Q28202926Peroxisome proliferator-activated receptors in cutaneous biology
Q34444007Perspective on HIV infection and aging: emerging research on the horizon
Q37727725Pharmacokinetic interactions between 20(S)-ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo.
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Q38172305Pharmacological management of cardiovascular conditions and diabetes in older adults with HIV infection
Q34674498Pilot study of coronary atherosclerotic risk and plaque burden in HIV patients: 'a call for cardiovascular prevention'.
Q41731825Practical approaches to HIV therapy. Recommendations for the year 2000.
Q44618019Pravastatin in hyperlipidemia secondary to HIV protease inhibitors without response to fenofibrate: a brief preliminary report.
Q35195032Prevalence and factors associated with dry skin in HIV infection: the FRAM study
Q42225235Prevalence and factors associated with lipodystrophy in AIDS patients
Q54052663Prevalence of drug resistant mutants and virological response to combination therapy in patients with primary HIV-1 infection.
Q78222299Probing the role of interfacial residues in a dimerization inhibitor of HIV-1 protease
Q33854196Procedure, applications, and outcomes of autologous fat grafting
Q45096972Progression of lipodystrophy (LD) with continued thymidine analogue usage: long-term follow-up from a randomized clinical trial (the PIILR study).
Q46246984Proinflammatory markers, insulin sensitivity, and cardiometabolic risk factors in treated HIV infection
Q44879927Prospective evaluation of blood concentration of mitochondrial DNA as a marker of toxicity in 157 consecutively recruited untreated or HAART-treated HIV-positive patients.
Q44081426Prospective, intensive study of metabolic changes associated with 48 weeks of amprenavir-based antiretroviral therapy
Q28344599Protease inhibitor related type III hyperlipoproteinaemia is common and not associated with apolipoprotein-E E2/E2 phenotype
Q34049924Protease inhibitor therapy and bleeding
Q54068035Protease inhibitor-associated angiolipomatosis.
Q38528072Protease inhibitor-induced lipodystrophy
Q42826034Protease inhibitors and adipocyte differentiation in cell culture.
Q41768073Protease inhibitors in HIV infection. Lipodystrophy may be a consequence of prolonged survival
Q46117356Rat chemokine CXCL11: structure, tissue distribution, function and expression in cardiac transplantation models
Q73980863Recent developments in the treatment of HIV disease
Q38162985Recent patents and emerging therapeutics for HIV infections: a focus on protease inhibitors
Q43695426Recurrent ingrown toenails secondary to indinavir/ritonavir combination therapy
Q40085569Relationship between estimated cardiovascular disease risk and insulin resistance in a black African population living with HIV: a cross-sectional study from Cameroon.
Q37192579Repositioning HIV protease inhibitors as cancer therapeutics
Q37016598Risk factors for cardiovascular disease in children infected with human immunodeficiency virus-1.
Q44024381Risk factors for the HIV-associated lipodystrophy syndrome in a closed cohort of patients after 3 years of antiretroviral treatment
Q34091370Risk of lipodystrophy in HIV-1-infected patients treated with protease inhibitors: a prospective cohort study
Q59341936Ritonavir incrementa la expresión de CD36 y ABCA1 en macrófagos THP-1
Q43866031Role of long-term nucleoside-analogue therapy in lipodystrophy and metabolic disorders in human immunodeficiency virus-infected patients
Q37563409Role of pregnane X receptor in obesity and glucose homeostasis in male mice
Q42834586Role of protease inhibitors and acylation stimulating protein in the adipogenesis in 3T3-L1 cells
Q44693675Serum L-lactate and pyruvate in HIV-infected patients with and without presumed NRTI-related adverse events compared to healthy volunteers
Q39607149Severe dyslipidemia and immune activation in HIV patients with dysglycemia
Q42807041Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapy
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Q34460031Sterol regulatory element-binding proteins and reactive oxygen species: potential role in highly-active antiretroviral therapy (HAART)-associated lipodystrophy
Q28372555Stimulation of vitamin A(1) acid signaling by the HIV protease inhibitor indinavir
Q33786358Strategies of antiretroviral therapy in adults
Q34056488Systemic manifestations of HIV infection
Q38239575Targeting strategies for delivery of anti-HIV drugs
Q27318414The Bile Acid Sensor FXR Protects against Dyslipidemia and Aortic Plaques Development Induced by the HIV Protease Inhibitor Ritonavir in Mice
Q34092295The Changing Epidemic of HIV.
Q44138786The HIV protease inhibitor ritonavir increases lipoprotein production and has no effect on lipoprotein clearance in mice.
Q59806829The Impact of Weight Gain During HIV Treatment on Risk of Pre-diabetes, Diabetes Mellitus, Cardiovascular Disease, and Mortality
Q37429096The Relationship Between HIV Infection and Cardiovascular Disease
Q32183747The Role of Caveolin 1 in HIV Infection and Pathogenesis
Q35557264The effect of aging, nutrition, and exercise during HIV infection
Q40625838The effect of human immunodeficiency virus-1 protease inhibitors on the toxicity of a variety of cells
Q43652600The effects of antiretroviral protease inhibitors on serum lipid levels in HIV-infected patients
Q37815335The effects of exercise training on metabolic and morphological outcomes for people living with HIV: a systematic review of randomised controlled trials
Q40678924The effects of protease inhibitors on basal and insulin-stimulated lipid metabolism, insulin binding, and signaling
Q43574806The evaluation of subcutaneous proleukin (interleukin-2) in a randomized international trial: rationale, design, and methods of ESPRIT.
Q34418859The fat redistribution syndrome in patients infected with HIV: measurements of body shape abnormalities
Q34122352The management of the clinical complications of antiretroviral therapy
Q34696505The molecular basis of genetic lipodystrophies
Q33865548The non-enumerable described retrovirus integrase inhibitors are not a lure, as evidenced by ten years of clinical experience
Q33827318The ophthalmologist and the global impact of the AIDS epidemic LV Edward Jackson Memorial Lecture
Q43818106The prevalence of lipodystrophy in an ambulant HIV-infected population: it all depends on the definition
Q27021950The roles of genetic polymorphisms and human immunodeficiency virus infection in lipid metabolism
Q45750384The science behind autologous fat grafting
Q37400616The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism
Q28292365The thrifty genotype in type 2 diabetes: an unfinished symphony moving to its finale?
Q40637184Three-drug combinations of emivirine and nucleoside reverse transcriptase inhibitors in vitro: long-term culture of HIV-1-infected cells and breakthrough viruses
Q44380825Thyroxine-derivatives of lipopeptides: bifunctional dimerization inhibitors of human immunodeficiency virus-1 protease
Q36544924Toxic metabolic syndrome associated with HAART.
Q35194751Toxicity of antiretroviral therapy and implications for drug development
Q36222023Treatment of dyslipidaemia in HIV-infected persons
Q44817515Treatment of lipodystrophy in patients with human immunodeficiency virus infection
Q28168652Treatment of metabolic syndrome
Q33639909Treatment options for hypertriglyceridemia: from risk reduction to pancreatitis
Q37661017Treatment-limiting toxicities associated withnucleoside analogue reverse transcriptase inhibitor therapy: A prospective, observational study
Q40601129Two novel single nucleotide polymorphisms in the promoter of the cellular retinoic acid binding protein II gene (CRABP-II).
Q42170740Ultrasonographic measurement of intra-abdominal fat thickness in HIV-infected patients treated or not with antiretroviral drugs and its correlation to lipid and glycemic profiles
Q44361070Ultrasonography in lesions of the carotid vessels in HIV positive patients
Q28378450Unexplained thrombosis in HIV-infected patients receiving protease inhibitors: report of seven cases
Q37362924Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1(+) smokers with early emphysema
Q35215799Use of HIV protease inhibitors to block Kaposi's sarcoma and tumour growth
Q57259689Use of metabolic drugs and fish oil in HIV-positive patients with metabolic complications and associations with dyslipidaemia and treatment targets
Q73425110Why have ten or so nontoxic, retrovirus integrase inhibitors not been made available for AIDS treatment? A ten-year experience [correction of experiment] must liberate them
Q77365435[Advances in the therapy of HIV infection and implications for clinical research]
Q81501645[Angiolipomas and antiretroviral therapy]
Q43654835[Antiretroviral therapy and cardiovascular risk]
Q83887838[Cutaneous drug reactions in HIV-infected patients in the HAART era]
Q81484014[HALS: HIV-Lipodystrophy associated syndrome]
Q75233906[Is there an increased risk for cardiovascular disease in HIV-infected patients on antiretroviral therapy?]
Q80426454[Liver and antiretrovirals: hepatotoxicity, steatosis and monitoring of patients with liver disease]

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