A randomized, double-blind, placebo-controlled, multicenter, parallel-group study to evaluate the efficacy and safety of adjunctive brivaracetam in adult patients with uncontrolled partial-onset seizures

scientific article published on 16 October 2015

A randomized, double-blind, placebo-controlled, multicenter, parallel-group study to evaluate the efficacy and safety of adjunctive brivaracetam in adult patients with uncontrolled partial-onset seizures is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/EPI.13212
P698PubMed publication ID26471380

P50authorChristian BrandtQ43961821
Michael R SperlingQ62092135
P2093author name stringJohn Whitesides
Wei Liang
Pavel Klein
Patrick Kwan
Jimmy Schiemann
Tracy Stalvey
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Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: a randomized, double-blind, placebo-controlled, parallel-group phase III studyQ46109122
SV2A protein is a broad-spectrum anticonvulsant target: functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsyQ46799583
SV2 modulates the size of the readily releasable pool of secretory vesiclesQ47205051
Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: a phase III randomized, double-blind, placebo-controlled trialQ48130509
Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties.Q51767935
Adjunctive brivaracetam in adults with uncontrolled focal epilepsy: results from a double-blind, randomized, placebo-controlled trial.Q51771465
Adjunctive brivaracetam for uncontrolled focal and generalized epilepsies: results of a phase III, double-blind, randomized, placebo-controlled, flexible-dose trial.Q54276194
The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetamQ24561949
Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)Q24655420
Modern antiepileptic drug development has failed to deliver: ways out of the current dilemmaQ27693823
Early identification of refractory epilepsyQ28144133
Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A.Q28281249
P433issue12
P921main subjectplaceboQ269829
patientQ181600
P304page(s)1890-1898
P577publication date2015-10-16
P1433published inEpilepsiaQ5382969
P1476titleA randomized, double-blind, placebo-controlled, multicenter, parallel-group study to evaluate the efficacy and safety of adjunctive brivaracetam in adult patients with uncontrolled partial-onset seizures
P478volume56

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