Safety and tolerability of adjunctive brivaracetam in epilepsy: In-depth pooled analysis

scientific article published on 12 January 2020

Safety and tolerability of adjunctive brivaracetam in epilepsy: In-depth pooled analysis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.YEBEH.2019.106864
P698PubMed publication ID31937513

P2093author name stringJohn Whitesides
Christian Brandt
Pavel Klein
Teresa Gasalla
Vincent Badalamenti
P2860cites workRisk of sudden unexpected death in epilepsy in patients given adjunctive antiepileptic treatment for refractory seizures: a meta-analysis of placebo-controlled randomised trialsQ28248717
The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after multiple increasing oral doses in healthy menQ28272717
Sudden unexpected death in epilepsy: epidemiology, mechanisms, and preventionQ30248253
Anticonvulsant drugs and hematological diseaseQ33413868
A systematic review of the safety profile of levetiracetam: a new antiepileptic drug.Q34416450
Assessing abuse liability during drug development: changing standards and expectations.Q37062910
Efficacy and safety of brivaracetam for partial-onset seizures in 3 pooled clinical studiesQ37113376
Hypersensitivity to antiepileptic drugsQ38228921
Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatmentQ38752407
Real-life experience with brivaracetam in 101 patients with difficult-to-treat epilepsy-A monocenter surveyQ38863377
Tolerability, safety, and efficacy of adjunctive brivaracetam for focal seizures in older patients: A pooled analysis from three phase III studiesQ39428102
Psychotic disorders induced by antiepileptic drugs in people with epilepsy.Q39509521
Safety, tolerability, and seizure control during long-term treatment with adjunctive brivaracetam for partial-onset seizuresQ39707630
The pharmacokinetics, CNS pharmacodynamics and adverse event profile of brivaracetam after single increasing oral doses in healthy malesQ41117944
Adjunctive brivaracetam for refractory partial-onset seizures: a randomized, controlled trial.Q42997736
Efficacy and tolerability of adjunctive brivaracetam in adults with uncontrolled partial-onset seizures: a phase IIb, randomized, controlled trialQ44773924
Effect of brivaracetam on cardiac repolarisation--a thorough QT studyQ46501773
Levetiracetam-associated hyponatremiaQ46515301
Human abuse potential of brivaracetam in healthy recreational central nervous system depressant usersQ47575581
Postmarketing experience with brivaracetam in the treatment of epilepsies: A multicenter cohort study from Germany.Q47733662
Safety and tolerability of adjunctive brivaracetam as intravenous infusion or bolus in patients with epilepsyQ47853821
A randomized, double-blind, placebo-controlled, multicenter, parallel-group study to evaluate the efficacy and safety of adjunctive brivaracetam in adult patients with uncontrolled partial-onset seizuresQ47926989
An open-label, prospective, exploratory study of patients with epilepsy switching from levetiracetam to brivaracetamQ47949546
Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: a phase III randomized, double-blind, placebo-controlled trialQ48130509
Evidence for a differential interaction of brivaracetam and levetiracetam with the synaptic vesicle 2A proteinQ48383809
Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties.Q51767935
Adjunctive brivaracetam in adults with uncontrolled focal epilepsy: results from a double-blind, randomized, placebo-controlled trial.Q51771465
Psychiatric and behavioral side effects of the newer antiepileptic drugs in adults with epilepsy.Q51910603
Bioavailability and bioequivalence comparison of brivaracetam 10, 50, 75, and 100 mg tablets and 100 mg intravenous bolus.Q53073031
Adjunctive brivaracetam for uncontrolled focal and generalized epilepsies: results of a phase III, double-blind, randomized, placebo-controlled, flexible-dose trial.Q54276194
Efficacy and tolerability of levetiracetam 3000 mg/d in patients with refractory partial seizures: a multicenter, double-blind, responder-selected study evaluating monotherapy. European Levetiracetam Study GroupQ73122171
Levetiracetam for partial seizures: results of a double-blind, randomized clinical trialQ74047711
Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures. European Levetiracetam Study GroupQ74351549
P433issuePt A
P304page(s)106864
P577publication date2020-01-12
P1433published inEpilepsy BehaviorQ15746410
P1476titleSafety and tolerability of adjunctive brivaracetam in epilepsy: In-depth pooled analysis
P478volume103