The Role of Resveratrol in Cancer Therapy.

scientific article published in December 2017

The Role of Resveratrol in Cancer Therapy. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3390/IJMS18122589
P932PMC publication ID5751192
P698PubMed publication ID29194365

P50authorGautam SethiQ50077635
Kwang Seok AhnQ60962653
P2093author name stringAlan Prem Kumar
Frank Arfuso
Jae-Young Um
Anupam Bishayee
Muthu K Shanmugam
Jeong-Hyeon Ko
P2860cites workChemoprevention of metaplasia initiation and carcinogenic progression to esophageal adenocarcinoma by resveratrol supplementation.Q46034296
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosisQ46203147
Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathwaysQ46367720
Resveratrol interferes with N-nitrosodiethylamine-induced hepatocellular carcinoma at early and advanced stages in male Wistar ratsQ46411332
The effect of initiating doses of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene on the expression of PAH activating enzymes and its modulation by plant phenolsQ46435008
Pterostilbene is equally potent as resveratrol in inhibiting 12-O-tetradecanoylphorbol-13-acetate activated NFkappaB, AP-1, COX-2, and iNOS in mouse epidermis.Q46542008
Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesisQ46803682
Chemopreventive effect of trans-resveratrol--a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesisQ46843553
Resveratrol is pro-apoptotic and thyroid hormone is anti-apoptotic in glioma cells: both actions are integrin and ERK mediatedQ46913650
Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn.Q49834882
Influence of resveratrol on oxidative damage in genomic DNA and apoptosis induced by cisplatinQ82407536
Potent inhibition of Lewis lung cancer growth by heyneanol A from the roots of Vitis amurensis through apoptotic and anti-angiogenic activitiesQ83288932
Modulatory influence of dietary resveratrol during different phases of 1,2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and aberrant crypt foci development in rat colon carcinogenesisQ83867996
Correlation of total polyphenolic content with antioxidant and antibacterial activity of 24 extracts from Greek domestic Lamiaceae speciesQ84914426
Resveratrol reduces the levels of circulating androgen precursors but has no effect on, testosterone, dihydrotestosterone, PSA levels or prostate volume. A 4-month randomised trial in middle-aged menQ87239863
Bioactive natural products in cancer prevention and therapy: Progress and promiseQ88211351
Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosisQ34613489
The multifaceted role of curcumin in cancer prevention and treatment.Q34667865
Recent advances in personalized lung cancer medicineQ34678073
STAT3 signaling: anticancer strategies and challenges.Q34715455
Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cellsQ34731017
Recent advances in chemoprevention of cancerQ34743443
Matrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trialsQ34776972
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.Q34859478
Resveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in ratsQ34880559
Resveratrol modulates the malignant properties of cutaneous melanoma through changes in the activation and attenuation of the antiapoptotic protooncogenic protein Akt/PKB.Q34917495
The molecular and genetic basis of colon cancerQ35037873
Resveratrol prevents inflammation-dependent hepatic melanoma metastasis by inhibiting the secretion and effects of interleukin-18Q35038576
Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors.Q35081777
Mechanisms and applications of non-steroidal anti-inflammatory drugs in the chemoprevention of cancerQ35082241
Molecular mechanism of the chemopreventive effect of resveratrolQ35082245
Resveratrol Downregulates Cyp2e1 and Attenuates Chemically Induced Hepatocarcinogenesis in SD RatsQ35094150
Study to evaluate molecular mechanics behind synergistic chemo-preventive effects of curcumin and resveratrol during lung carcinogenesisQ35140169
Resveratrol targets transforming growth factor-β2 signaling to block UV-induced tumor progressionQ35156138
Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expressionQ35185008
Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamicsQ35215147
Natural bioactives in cancer treatment and preventionQ35337444
Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cellsQ35585136
Anticancer therapy targeting the apoptotic pathwayQ35603092
The role of oxidative stress in carcinogenesisQ35639135
CArG-driven GADD45α activated by resveratrol inhibits lung cancer cellsQ35786657
Enhancing the bioavailability of resveratrol by combining it with piperineQ35807346
DNA damage responses to oxidative stressQ35848526
Pathways of apoptotic and non-apoptotic death in tumour cellsQ35852309
Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTPε and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinomaQ35934532
Exploiting death receptor signaling pathways for tumor therapyQ35976606
Apoptosis pathway-targeted drugs--from the bench to the clinicQ35976616
Sensitization of TRAIL-resistant LNCaP cells by resveratrol (3, 4', 5 tri-hydroxystilbene): molecular mechanisms and therapeutic potentialQ36059686
Trans-resveratrol alters mammary promoter hypermethylation in women at increased risk for breast cancerQ36082837
Nrf2 as a novel molecular target for chemopreventionQ36137929
Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responsesQ23921756
Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathwayQ24301518
Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFkappaB)Q24338549
Diet, nutrition, and avoidable cancerQ24554391
Resveratrol and clinical trials: the crossroad from in vitro studies to human evidenceQ24618313
Cyclodextrin-based nanosponges for delivery of resveratrol: in vitro characterisation, stability, cytotoxicity and permeation studyQ24630364
Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesisQ24630499
Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?Q26775940
Epithelial-mesenchymal transitions in development and diseaseQ27860630
Resveratrol improves health and survival of mice on a high-calorie dietQ27860950
Curcumin and Resveratrol in the Management of Cognitive Disorders: What is the Clinical Evidence?Q28071699
Oxidative Stress and Carbonyl Lesions in Ulcerative Colitis and Associated Colorectal CancerQ28073745
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibitionQ28115131
Role of transforming growth factor beta in human diseaseQ28143408
The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studiesQ28242320
Cancer prevention and treatment with resveratrol: from rodent studies to clinical trialsQ28243127
Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysisQ28258638
Nuclear factor-kappaB activation: from bench to bedsideQ28262629
Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cellsQ28275069
Cancer chemopreventive activity of resveratrol, a natural product derived from grapesQ28300555
A perspective on cancer cell metastasisQ28307891
Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophagesQ28371964
Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrolQ28373207
Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin productionQ28373255
Effects of resveratrol on 12-O-tetradecanoylphorbol-13-acetate-induced oxidative events and gene expression in mouse skinQ28378146
Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70Q28472533
Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cellsQ28476510
Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transitionQ28477031
Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting effect of resveratrol in glioma cellsQ28478548
Pterostilbene acts through metastasis-associated protein 1 to inhibit tumor growth, progression and metastasis in prostate cancerQ28487488
Resveratrol inhibits the growth of gastric cancer by inducing G1 phase arrest and senescence in a Sirt1-dependent mannerQ28535352
Resveratrol inhibits breast cancer stem-like cells and induces autophagy via suppressing Wnt/β-catenin signaling pathwayQ28541242
The suppressive effect of resveratrol on HIF-1α and VEGF expression after warm ischemia and reperfusion in rat liverQ28543622
STATs in cancer inflammation and immunity: a leading role for STAT3Q29547203
The biochemistry of apoptosisQ29547741
Caspases: killer proteasesQ29616315
Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.Q30156868
Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs.Q30654525
Anticancer activity of resveratrol on implanted human primary gastric carcinoma cells in nude miceQ30844349
Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factorQ30994649
Resveratrol induces Fas signalling-independent apoptosis in THP-1 human monocytic leukaemia cellsQ31394503
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cellsQ33260568
A phase I study of muscadine grape skin extract in men with biochemically recurrent prostate cancer: Safety, tolerability, and dose determinationQ33465128
Modulating apoptosis: current applications and prospects for future drug developmentQ33547637
Nrf2: friend or foe for chemoprevention?Q33575690
Resveratrol and cancer: focus on in vivo evidenceQ33578943
Apoptosis control by death and decoy receptorsQ33597389
Environmental factors as regulators and effectors of multistep carcinogenesisQ33605331
Interaction of the TNFR-receptor associated factor TRAF1 with I-kappa B kinase-2 and TRAF2 indicates a regulatory function for NF-kappa B signalingQ33698109
Novel medicines and strategies in cancer treatment and preventionQ33757743
Resveratrol suppresses colitis and colon cancer associated with colitisQ33785741
Metabolism of chemical carcinogensQ33846166
Matrix metalloproteinases: biologic activity and clinical implicationsQ33849967
Resveratrol inhibits the epithelial-mesenchymal transition of pancreatic cancer cells via suppression of the PI-3K/Akt/NF-κB pathwayQ33857806
Exacerbation of tobacco smoke mediated apoptosis by resveratrol: an unexpected consequence of its antioxidant actionQ33939226
Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing miceQ33949182
Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless miceQ33964317
Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivinQ33982153
Resveratrol bioavailability and toxicity in humansQ34020588
Resveratrol inhibits TGF-β1-induced epithelial-to-mesenchymal transition and suppresses lung cancer invasion and metastasisQ34034339
Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factorsQ34042949
Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models.Q34095558
Resveratrol chemosensitizes breast cancer cells to melphalan by cell cycle arrestQ39380056
MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrolQ39381116
Cisplatin and resveratrol induce apoptosis and autophagy following oxidative stress in malignant mesothelioma cellsQ39425336
Resveratrol modulates MED28 (Magicin/EG-1) expression and inhibits epidermal growth factor (EGF)-induced migration in MDA-MB-231 human breast cancer cells.Q39469276
Resveratrol inhibits the epidermal growth factor-induced epithelial mesenchymal transition in MCF-7 cellsQ39499880
Resveratrol selectively induces DNA Damage, independent of Smad4 expression, in its efficacy against human head and neck squamous cell carcinoma.Q39517822
Resveratrol reduces the invasive growth and promotes the acquisition of a long-lasting differentiated phenotype in human glioblastoma cellsQ39577641
Regulation of p53 and cell proliferation by resveratrol and its derivatives in breast cancer cells: an in silico and biochemical approach targeting integrin αvβ3.Q39608950
Inducible COX-2-dependent apoptosis in human ovarian cancer cellsQ39615322
Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signalingQ39618565
Inhibition of NF-κB signaling commits resveratrol-treated medulloblastoma cells to apoptosis without neuronal differentiationQ39619523
Resveratrol Arrests Cell Cycle and Induces Apoptosis in Human Hepatocellular Carcinoma Huh-7 CellsQ39644247
Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell linesQ39664750
Resveratrol induces cell-cycle disruption and apoptosis in chemoresistant B16 melanomaQ39690550
NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cellsQ39721374
Evaluation of anti-invasion effect of resveratrol and related methoxy analogues on human hepatocarcinoma cells.Q39743879
Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivoQ39760176
Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch by topical application of resveratrol complexed with 2-hydroxypropyl-beta-cyclodextrinQ39771922
Synthesis, structural characterisation and biological evaluation of fluorinated analogues of resveratrolQ39845203
Regulation of cell survival by resveratrol involves inhibition of NF kappa B-regulated gene expression in prostate cancer cells.Q39870498
Antiproliferative activities of resveratrol and related compounds in human hepatocyte derived HepG2 cells are associated with biochemical cell disturbance revealed by fluorescence analysesQ39961239
Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cellsQ39986919
Oncogenic CARD11 mutations in human diffuse large B cell lymphomaQ40005246
Resveratrol inhibits tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cellsQ40055255
Resveratrol-induced apoptosis in human T-cell acute lymphoblastic leukaemia MOLT-4 cellsQ40080473
Resveratrol inhibits glucose metabolism in human ovarian cancer cellsQ40083419
Resveratrol inhibits tumor growth of human neuroblastoma and mediates apoptosis by directly targeting mitochondriaQ40085440
Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol.Q40130225
Constitutive and inducible nuclear factor-kappaB in immortalized normal human bronchial epithelial and non-small cell lung cancer cell lines.Q40134478
Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9.Q40171255
Inhibition of phosphatidylinositol 3-kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomasQ40231229
NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2.Q40252191
Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model.Q40319010
Resveratrol induces apoptosis of human malignant B cells by activation of caspase-3 and p38 MAP kinase pathwaysQ40326791
Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.Q40462433
Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB.Q40462439
trans-3,4,5'-Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cellsQ40527959
Resveratrol-induced cellular apoptosis and cell cycle arrest in neuroblastoma cells and antitumor effects on neuroblastoma in mice.Q40539459
Resveratrol suppresses the angiogenesis and tumor growth of gliomas in ratsQ40574085
Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosisQ40594629
Involvement of p21WAF1/CIP1, pRB, Bax and NF-kappaB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 cellsQ40636195
Involvement of c-jun NH(2)-terminal kinases in resveratrol-induced activation of p53 and apoptosisQ40740259
Induction of quinone reductase activity by stilbene analogs in mouse Hepa 1c1c7 cellsQ40756723
Resveratrol, a natural phenolic compound, inhibits cell proliferation and prevents oxidative DNA damage.Q40781318
Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell linesQ40789054
Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinaseQ40821365
Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cellsQ40847302
Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cellsQ41021779
Resveratrol: a molecule whose time has come? And gone?Q41452058
Effect of resveratrol on cell cycle proteins in murine transplantable liver cancerQ41822993
Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancerQ41841905
Antitumor and immunomodulatory activity of resveratrol on experimentally implanted tumor of H22 in Balb/c miceQ42204516
Metabonomic variations associated with AOM-induced precancerous colorectal lesions and resveratrol treatment.Q50512761
Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis.Q50540880
Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.Q50711998
In vitro and in vivo evaluation of the antitumor efficiency of resveratrol against lung cancer.Q50989456
Fas-dependent and -independent mechanisms of cell death following DNA damage in human colon carcinoma cells.Q51080573
Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.Q51091938
Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo[4,5-f]quinoline.Q51778003
Induction of quinone reductase NQO1 by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2.Q52573261
Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer.Q52682976
Premature mitochondrial senescence and related ultrastructural changes during lung carcinogenesis modulation by curcumin and resveratrol.Q53270682
Dietary supplementation of resveratrol suppresses colonic tumour incidence in 1,2-dimethylhydrazine-treated rats by modulating biotransforming enzymes and aberrant crypt foci development.Q53343614
Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression.Q53407584
Resveratrol suppresses prostate cancer progression in transgenic mice.Q53536458
Constitutive activation of NF-kappaB in human hepatocellular carcinoma: evidence of a cytoprotective role.Q53631902
Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice.Q54070216
Hypoxia-induced necrotizing enterocolitis in the immature rat: the role of lipid peroxidation and management by vitamin EQ71483979
The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitorsQ71524901
Screening of potential chemopreventive agents using biochemical markers of carcinogenesisQ72789801
Resveratrol is a potent inhibitor of the dioxygenase activity of lipoxygenaseQ73292946
Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potentialQ74081784
Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cellsQ74163308
Resveratrol-induced activation of the mitogen-activated protein kinases, ERK1 and ERK2, in human neuroblastoma SH-SY5Y cellsQ77729742
Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J miceQ77899711
Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour modelQ77911805
The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injuryQ78115656
Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer studyQ34103899
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.Q34139321
Inhibition of cancer growth by resveratrol is related to its low bioavailabilityQ34139845
Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolicsQ34153260
Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells.Q34153961
The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.Q34164259
Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.Q34168543
NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytesQ34207369
Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-cultureQ34306523
Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor AxisQ34316229
Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cycle arrestQ34329286
Epithelial-mesenchymal transition: NF-kappaB takes center stageQ34367143
The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cellsQ34386629
Integrin alphaVbeta3 contains a cell surface receptor site for thyroid hormone that is linked to activation of mitogen-activated protein kinase and induction of angiogenesisQ34407789
Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancerQ34418424
Resveratrol: review on therapeutic potential and recent advances in drug delivery.Q34420121
Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamstersQ34480835
Natural Products as Sources of New Drugs from 1981 to 2014.Q34512692
Phytoalexins from the Vitaceae: biosynthesis, phytoalexin gene expression in transgenic plants, antifungal activity, and metabolismQ34522777
Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrolQ34526413
Wine, alcohol, platelets, and the French paradox for coronary heart diseaseQ34538674
Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms.Q34548393
Differential induction of quinone reductase by phytoestrogens and protection against oestrogen-induced DNA damageQ34551489
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.Q34552323
Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?Q34556885
Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivoQ34563439
Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/Akt pathway and Bcl-2 family proteinsQ34567861
A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormonesQ34570111
Resveratrol is rapidly metabolized in athymic (nu/nu) mice and does not inhibit human melanoma xenograft tumor growthQ34571083
Mechanisms involved in resveratrol-induced apoptosis and cell cycle arrest in prostate cancer-derived cell linesQ34571886
Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expressionQ34586249
Natural products induce a G protein-mediated calcium pathway activating p53 in cancer cellsQ36207566
Effect of resveratrol on the metastasis of 4T1 mouse breast cancer cells in vitro and in vivoQ36227449
Chemoprevention of benzo(a)pyrene-induced colon polyps in ApcMin mice by resveratrolQ36403593
Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cellsQ36625922
Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[a]pyreneQ36695705
Reactive oxygen species: a breath of life or death?Q36731940
Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination TherapiesQ36759354
Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and miceQ36786996
Prevention of estrogen-DNA adduct formation in MCF-10F cells by resveratrol.Q36807739
Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse modelQ36831357
Pathology of rodent models of intestinal cancer: progress report and recommendationsQ36865701
Resveratrol: from basic science to the clinicQ36921873
Nuclear factor-kappa B: from clone to clinicQ37017902
NF-kappaB and epithelial to mesenchymal transition of cancerQ37078242
Caveolin-1 enhances resveratrol-mediated cytotoxicity and transport in a hepatocellular carcinoma modelQ37177054
Aryl hydrocarbon receptor pathway activation enhances gastric cancer cell invasiveness likely through a c-Jun-dependent induction of matrix metalloproteinase-9.Q37188766
Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectivesQ37190153
Effects of combined phytochemicals on skin tumorigenesis in SENCAR miceQ37209501
Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genesQ37227343
NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progressionQ37286365
Differential effects of resveratrol on androgen-responsive LNCaP human prostate cancer cells in vitro and in vivoQ37294641
Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe.Q37369658
Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer.Q37370826
Resveratrol enhances cell-mediated immune response to DMBA through TLR4 and prevents DMBA induced cutaneous carcinogenesisQ37383667
Natural bioactives and phytochemicals serve in cancer treatment and prevention.Q37433047
Potential pharmacological control of the NF-κB pathwayQ37484609
MMP-9 and MMP-2 gelatinases and TIMP-1 and TIMP-2 inhibitors in breast cancer: correlations with prognostic factorsQ37600292
Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemopreventionQ37619775
Resveratrol in the chemoprevention and treatment of hepatocellular carcinomaQ37632027
Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicalsQ37646827
The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancerQ37759799
Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer.Q37822109
Clinical trials of resveratrolQ37831946
Resveratrol, a phytochemical inducer of multiple cell death pathways: apoptosis, autophagy and mitotic catastropheQ37835313
Targeting cell signaling and apoptotic pathways by dietary agents: role in the prevention and treatment of cancer.Q37835758
Multifaceted link between cancer and inflammationQ37943405
Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: potential role in prevention and therapy of cancerQ37992480
Chemoprevention of liver cancer by plant polyphenols.Q38004259
Regulation of EMT by TGFβ in cancer.Q38019712
Key cell signaling pathways modulated by zerumbone: role in the prevention and treatment of cancer.Q38030337
NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancerQ38088677
Animal models of disease: pre-clinical animal models of cancer and their applications and utility in drug discoveryQ38118539
Resveratrol in the management of human cancer: how strong is the clinical evidence?Q38121595
The complexity of NF-κB signaling in inflammation and cancerQ38126565
Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.Q38130366
Enhancing the delivery of resveratrol in humans: if low bioavailability is the problem, what is the solution?Q38262965
NF-κB in cancer therapy.Q38359190
Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell lineQ38364091
Analysis of the intricate relationship between chronic inflammation and cancer.Q38458724
Resveratrol in the treatment of pancreatic cancer.Q38568979
Targeting transcription factor STAT3 for cancer prevention and therapy.Q38610564
Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms.Q38698794
Prevention and treatment of cancers by immune modulating nutrients.Q38718929
Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells.Q38779367
Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds.Q38796417
Topical treatment with pterostilbene, a natural phytoalexin, effectively protects hairless mice against UVB radiation-induced skin damage and carcinogenesis.Q38890614
Resveratrol suppresses vascular endothelial growth factor secretion via inhibition of CXC-chemokine receptor 4 expression in ARPE-19 cellsQ38894373
Polyphenols in dementia: From molecular basis to clinical trials.Q38919226
Resveratrol mediated cell death in cigarette smoke transformed breast epithelial cells is through induction of p21Waf1/Cip1 and inhibition of long patch base excision repair pathwayQ39030134
Cancer Statistics, 2017.Q39038674
Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathwaysQ39156783
Resveratrol enhances the efficacy of sorafenib mediated apoptosis in human breast cancer MCF7 cells through ROS, cell cycle inhibition, caspase 3 and PARP cleavageQ39173646
The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude miceQ39190914
Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation.Q39308056
Resveratrol exerts differential effects in vitro and in vivo against ovarian cancer cells.Q39313933
The flavonoid resveratrol suppresses growth of human malignant pleural mesothelioma cells through direct inhibition of specificity protein 1.Q39354770
Grape extracts suppress the formation of preneoplastic foci and activity of fatty acid synthase in rat liverQ42453551
Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissueQ42707291
Impairment of tumor-initiating stem-like property and reversal of epithelial-mesenchymal transdifferentiation in head and neck cancer by resveratrol treatmentQ42717496
Resveratrol helps recovery from fatty liver and protects against hepatocellular carcinoma induced by hepatitis B virus X protein in a mouse modelQ42717718
Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells.Q42744038
Resveratrol inhibits VEGF expression of human hepatocellular carcinoma cells through a NF-kappa B-mediated mechanism.Q42745880
Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathwayQ42748324
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrolQ42798510
Extinction of rac1 and Cdc42Hs signalling defines a novel p53-dependent apoptotic pathwayQ42801438
Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential targetQ42834044
Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects.Q43042961
The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer.Q43044975
trans-Resveratrol reduces precancerous colonic lesions in dimethylhydrazine-treated ratsQ43045324
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesisQ43054538
Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesisQ43092680
Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive effects of resveratrol in liver cancer cellsQ43172916
Effect of resveratrol and in combination with 5-FU on murine liver cancerQ43245452
Influence of dietary resveratrol on early and late molecular markers of 1,2-dimethylhydrazine-induced colon carcinogenesisQ43264365
Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinomaQ43265295
Resveratrol causes WAF-1/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cellsQ43606287
Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells.Q43640339
Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways.Q43641994
Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2.Q43654467
Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapesQ43693027
Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposisQ43758043
A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myelomaQ43887370
Effect of resveratrol on growth of 4T1 breast cancer cells in vitro and in vivoQ43897387
Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studiesQ43963634
A comparison of the anticarcinogenic properties of four red wine polyphenolsQ43975950
Revisiting ischemia and reperfusion injury as a possible cause of necrotizing enterocolitis: Role of nitric oxide and superoxide dismutaseQ44011055
Cytotoxic and antimutagenic stilbenes from seeds of Paeonia lactifloraQ44074878
Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells.Q44084996
Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesisQ44090241
Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9.Q44123696
Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing ratsQ44506224
Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene.Q44528215
Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cellsQ44539335
Prepubertal resveratrol exposure accelerates N-methyl-N-nitrosourea-induced mammary carcinoma in female Sprague-Dawley ratsQ44672494
Antiproliferative effect of resveratrol in human prostate carcinoma cellsQ44772387
Modulations of critical cell cycle regulatory events during chemoprevention of ultraviolet B-mediated responses by resveratrol in SKH-1 hairless mouse skinQ44879952
Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cellsQ44895757
The 3,4-dihydroxyl groups are important for trans-resveratrol analogs to exhibit enhanced antioxidant and apoptotic activitiesQ44908805
Lack of ABCG2 shortens latency of BRCA1-deficient mammary tumors and this is not affected by genistein or resveratrolQ44975292
Resveratrol inhibits phorbol ester-induced cyclooxygenase-2 expression in mouse skin: MAPKs and AP-1 as potential molecular targetsQ45210018
Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cellsQ45249210
Pharmacokinetics, tissue distribution and excretion study of resveratrol and its prodrug 3,5,4'-tri-O-acetylresveratrol in ratsQ45894686
Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model.Q45913515
Resveratrol ameliorates DNA damage, prooxidant and antioxidant imbalance in 1,2-dimethylhydrazine induced rat colon carcinogenesis.Q45970594
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectresveratrolQ407329
stilbenoidQ526360
neoplasmQ1216998
phytogenic antineoplastic agentsQ50377200
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P577publication date2017-12-01
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleThe Role of Resveratrol in Cancer Therapy
P478volume18

Reverse relations

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