Charged Antimicrobial Peptides Can Translocate across Membranes without Forming Channel-like Pores

scientific article published in July 2017

Charged Antimicrobial Peptides Can Translocate across Membranes without Forming Channel-like Pores is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BPJ.2017.04.056
P8608Fatcat IDrelease_r5ihayoek5fmvizcs33eqjmp54
P932PMC publication ID5510918
P698PubMed publication ID28700927

P2093author name stringJakob P Ulmschneider
P2860cites workStudies on anticancer activities of antimicrobial peptidesQ24650885
Crystal structure and functional mechanism of a human antimicrobial membrane channelQ27676492
All-atom empirical potential for molecular modeling and dynamics studies of proteinsQ27860468
AMPs and OMPs: Is the folding and bilayer insertion of β-stranded outer membrane proteins governed by the same biophysical principles as for α-helical antimicrobial peptides?Q28085678
Partitioning of amino acid side chains into lipid bilayers: results from computer simulations and comparison to experimentQ42868391
Solid-state NMR analysis of the PGLa peptide orientation in DMPC bilayers: structural fidelity of 2H-labels versus high sensitivity of 19F-NMR.Q43203645
Biosynthesis of peptides in the skin of Xenopus laevis: isolation of novel peptides predicted from the sequence of cloned cDNAsQ43500383
Orientation of the antimicrobial peptide PGLa in lipid membranes determined from 19F-NMR dipolar couplings of 4-CF3-phenylglycine labelsQ44843208
Kinetics of dye efflux and lipid flip-flop induced by delta-lysin in phosphatidylcholine vesicles and the mechanism of graded release by amphipathic, alpha-helical peptidesQ44965743
2H-NMR and MD Simulations Reveal Membrane-Bound Conformation of Magainin 2 and Its Synergy with PGLaQ45394261
How reliable are molecular dynamics simulations of membrane active antimicrobial peptides?Q45889486
Temperature-dependent transmembrane insertion of the amphiphilic peptide PGLa in lipid bilayers observed by solid state 19F NMR spectroscopyQ46428881
Toroidal pores formed by antimicrobial peptides show significant disorder.Q46500589
Influence of hydrophobic residues on the activity of the antimicrobial peptide magainin 2 and its synergy with PGLaQ46576827
Mechanism of synergism between antimicrobial peptides magainin 2 and PGLaQ46725670
Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides.Q47354537
Investigations of the synergistic enhancement of antimicrobial activity in mixtures of magainin 2 and PGLa.Q52661220
Antimicrobial properties of peptides from Xenopus granular gland secretions.Q54753015
Evaluating the amino acid CF3-bicyclopentylglycine as a new label for solid-state19F-NMR structure analysis of membrane-bound peptidesQ57528485
Synergistic Transmembrane Alignment of the Antimicrobial Heterodimer PGLa/MagaininQ57528502
A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptidesQ60314981
Orientations of amphipathic helical peptides in membrane bilayers determined by solid-state NMR spectroscopyQ67715527
Orientations of helical peptides in membrane bilayers by solid state NMR spectroscopyQ73109728
Antimicrobial peptides in actionQ80248535
Mechanism and kinetics of peptide partitioning into membranes from all-atom simulations of thermostable peptidesQ82934708
Magainin 2-PGLa Interactions in Membranes - Two Peptides that Exhibit Synergistic Enhancement of Antimicrobial ActivityQ85520459
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?Q29547675
Update of the CHARMM all-atom additive force field for lipids: validation on six lipid typesQ29616710
Real-time attack on single Escherichia coli cells by the human antimicrobial peptide LL-37.Q30499787
Conditions affecting the re-alignment of the antimicrobial peptide PGLa in membranes as monitored by solid state 2H-NMR.Q31041649
Simulations of Membrane-Disrupting Peptides II: AMP Piscidin 1 Favors Surface Defects over PoresQ31132190
Membrane binding and pore formation of the antibacterial peptide PGLa: thermodynamic and mechanistic aspectsQ31448673
Diversity of antimicrobial peptides and their mechanisms of actionQ33789705
A novel peptide designated PYLa and its precursor as predicted from cloned mRNA of Xenopus laevis skinQ33933506
Spontaneous transmembrane helix insertion thermodynamically mimics translocon-guided insertionQ34169643
Structure and dynamics of the antibiotic peptide PGLa in membranes by solution and solid-state nuclear magnetic resonance spectroscopyQ34179987
Antimicrobial peptides: properties and applicabilityQ34280947
Lipid-controlled peptide topology and interactions in bilayers: structural insights into the synergistic enhancement of the antimicrobial activities of PGLa and magainin 2Q34688801
A membrane-translocating peptide penetrates into bilayers without significant bilayer perturbationsQ34762673
In silico partitioning and transmembrane insertion of hydrophobic peptides under equilibrium conditionsQ35321610
Mechanism of the cell-penetrating peptide transportan 10 permeation of lipid bilayersQ35781208
Pore Structure and Synergy in Antimicrobial Peptides of the Magainin FamilyQ35884094
Reorientation and dimerization of the membrane-bound antimicrobial peptide PGLa from microsecond all-atom MD simulationsQ36150814
Molecular mechanism of antimicrobial peptides: the origin of cooperativityQ36423350
APD3: the antimicrobial peptide database as a tool for research and educationQ36434966
Solid-phase synthesis of PYLa and isolation of its natural counterpart, PGLa [PYLa-(4-24)] from skin secretion of Xenopus laevis.Q36485325
Lights, Camera, Action! Antimicrobial Peptide Mechanisms Imaged in Space and Time.Q36522058
How translocons select transmembrane helicesQ37197960
Synergistic transmembrane insertion of the heterodimeric PGLa/magainin 2 complex studied by solid-state NMR.Q37409630
Wasp mastoparans follow the same mechanism as the cell-penetrating peptide transportan 10.Q37414151
Spontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptideQ37434421
Biological activity and structural aspects of PGLa interaction with membrane mimetic systemsQ37501261
Translocation of cationic amphipathic peptides across the membranes of pure phospholipid giant vesiclesQ37581034
Antimicrobial peptides: successes, challenges and unanswered questionsQ37827731
Antimicrobial peptides: key components of the innate immune systemQ37954721
Membrane topologies of the PGLa antimicrobial peptide and a transmembrane anchor sequence by Dynamic Nuclear Polarization/solid-state NMR spectroscopy.Q38432940
Mechanism and kinetics of delta-lysin interaction with phospholipid vesiclesQ39403185
Concentration-dependent realignment of the antimicrobial peptide PGLa in lipid membranes observed by solid-state 19F-NMR.Q40329241
Antimicrobial Peptide Simulations and the Influence of Force Field on the Free Energy for Pore Formation in Lipid BilayersQ40574291
Structure-activity studies on magainins and other host defense peptidesQ40614396
Coarse-grained simulations of the membrane-active antimicrobial Peptide maculatin 1.1.Q41999493
A highly charged voltage-sensor helix spontaneously translocates across membranesQ42140924
Spontaneous membrane-translocating peptides by orthogonal high-throughput screeningQ42254224
Charge Distribution Fine-Tunes the Translocation of α-Helical Amphipathic Peptides across MembranesQ42381525
Peptide partitioning properties from direct insertion studiesQ42754550
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectantimicrobial peptideQ1201508
P1104number of pages9
P304page(s)73-81
P577publication date2017-07-01
P1433published inBiophysical JournalQ2032955
P1476titleCharged Antimicrobial Peptides Can Translocate across Membranes without Forming Channel-like Pores
P478volume113

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cites work (P2860)
Q57806448A brief appraisal of computational modeling of antimicrobial peptides' activity
Q88837351And Yet It Moves
Q55515973Antimicrobial Peptides in the Cross Hairs of Computer Simulations.
Q92733951Binding and Flip as Initial Steps for BP-100 Antimicrobial Actions
Q57828969Computed Free Energies of Peptide Insertion into Bilayers are Independent of Computational Method
Q89167973Effects of Peptide Charge, Orientation, and Concentration on Melittin Transmembrane Pores
Q58717273Membrane Active Peptides and Their Biophysical Characterization
Q59885157Microscopic view of lipids and their diverse biological functions
Q52691175Molecular Dynamics Simulations of Human Antimicrobial Peptide LL-37 in Model POPC and POPG Lipid Bilayers.
Q88576329Molecular dynamics simulations of lipid nanodiscs
Q42377280Molecular mechanism of synergy between the antimicrobial peptides PGLa and magainin 2.
Q90459715Non-Lytic Antibacterial Peptides That Translocate Through Bacterial Membranes to Act on Intracellular Targets
Q89011249Single-Molecule Resolution of Antimicrobial Peptide Interactions with Supported Lipid A Bilayers
Q92069996Snake Venom Cathelicidins as Natural Antimicrobial Peptides
Q57191655The importance of the membrane interface as the reference state for membrane protein stability

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