Selective deficiency of the "bone-related" Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis.

scientific article published on 7 March 2004

Selective deficiency of the "bone-related" Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M401109200
P698PubMed publication ID15007057

P50authorL. Darryl QuarlesQ55873742
Anita B HjelmelandQ79749075
P2093author name stringZhou-Sheng Xiao
P2860cites workThe novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formationQ24292169
Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasiaQ24309601
AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localizationQ24311698
Alternative splicing and genomic structure of theAML1gene involved in acute myeloid leukemiaQ24626212
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytesQ24628843
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone developmentQ28119185
Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activationQ28201036
Osf2/Cbfa1: a transcriptional activator of osteoblast differentiationQ28240596
Maturational disturbance of chondrocytes in Cbfa1-deficient miceQ28506259
Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic developmentQ28507097
Causal relationship between the loss of RUNX3 expression and gastric cancerQ28509530
Regulation of chondrocyte differentiation by Cbfa1Q28509820
Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factorQ28577403
The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosisQ28593565
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblastsQ29547605
Expression and function of a stem cell promoter for the murine CBFalpha2 gene: distinct roles and regulation in natural killer and T cell development.Q30659791
Phosphate provides an extracellular signal that drives nuclear export of Runx2/Cbfa1 in bone cellsQ31855317
Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with CbfbetaQ33774997
High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineageQ34285654
FGF signaling pathways in endochondral and intramembranous bone development and human genetic diseaseQ34702208
Distinct requirements for Ras oncogenesis in human versus mouse cellsQ34787097
Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null backgroundQ34890442
Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient miceQ35076965
A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic developmentQ35194624
Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fracturesQ36293998
PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 geneQ36436030
Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogeneQ36552332
Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regionsQ37705859
A PEBP2 alpha/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting elementQ38287692
Cbfa1 is a positive regulatory factor in chondrocyte maturationQ38314367
Cbfa1 isoforms exert functional differences in osteoblast differentiationQ38327457
Activation of Peroxisome Proliferator-activated Receptor-γ Inhibits the Runx2-mediated Transcription of Osteocalcin in OsteoblastsQ40653979
Induction of Osteoclast Differentiation by Runx2 through Receptor Activator of Nuclear Factor-κB Ligand (RANKL) and Osteoprotegerin Regulation and Partial Rescue of Osteoclastogenesis in Runx2–/– Mice by RANKL TransgeneQ40655044
IRES-dependent translational control of Cbfa1/Runx2 expression.Q40676811
Characterization of the upstream mouse Cbfa1/Runx2 promoterQ40786632
MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1.Q40901916
Isolation and characterization of the distal promoter region of mouse Cbfa1.Q40922634
Expression of the PEBP2alphaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cellsQ42451259
Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alphaQ42513418
Role of the alpha2-integrin in osteoblast-specific gene expression and activation of the Osf2 transcription factorQ42824205
Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2.Q42826927
Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytesQ42934690
Differential expression patterns of Runx2 isoforms in cranial suture morphogenesisQ43599975
Runx2 deficiency in chondrocytes causes adipogenic changes in vitroQ44711017
Spatio-temporal expression patterns of Runx2 isoforms in early skeletogenesis.Q51032246
Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1Q57338760
Runx3 is essential for the target-specific axon pathfinding of trkc-expressing dorsal root ganglion neuronsQ73355288
Transcriptional mechanisms in osteoblast differentiation and bone formationQ73763993
Genomic organization, expression of the human CBFA1 gene, and evidence for an alternative splicing event affecting protein functionQ74063837
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectosteoblastQ917177
P304page(s)20307-20313
P577publication date2004-03-07
P1433published inJournal of Biological ChemistryQ867727
P1476titleSelective deficiency of the "bone-related" Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis
P478volume279

Reverse relations

cites work (P2860)
Q89495643Abnormal expression of miR-135b-5p in bone tissue of patients with osteoporosis and its role and mechanism in osteoporosis progression
Q37318849Advances in osteoclast biology resulting from the study of osteopetrotic mutations.
Q53615857Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development.
Q35636978Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse
Q35022641Cilia involvement in patterning and maintenance of the skeleton
Q35634081Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression.
Q38858036Cleidocranial dysplasia and RUNX2-clinical phenotype-genotype correlation
Q35559060Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice
Q33569659Conditional disruption of Pkd1 in osteoblasts results in osteopenia due to direct impairment of bone formation.
Q34430664Conditional mesenchymal disruption of pkd1 results in osteopenia and polycystic kidney disease.
Q36279535Core binding factor beta (Cbfβ) controls the balance of chondrocyte proliferation and differentiation by upregulating Indian hedgehog (Ihh) expression and inhibiting parathyroid hormone-related protein receptor (PPR) expression in postnatal cartilag
Q37122129Diagnosis of osteoporosis with vitamin k as a new biochemical marker
Q46283520Differential regulation of dentin sialophosphoprotein expression by Runx2 during odontoblast cytodifferentiation
Q35990019Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia
Q28588130Dlx5 Is a cell autonomous regulator of chondrocyte hypertrophy in mice and functionally substitutes for Dlx6 during endochondral ossification
Q38321841Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter
Q41874349Dlx5, a positive regulator of osteoblastogenesis, is essential for osteoblast-osteoclast coupling.
Q37396635Dose-dependent effects of Runx2 on bone development.
Q33636577Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis
Q39451500Downregulation of PKD1 by shRNA results in defective osteogenic differentiation via cAMP/PKA pathway in human MG-63 cells
Q35737205Ectopic expression of SOX9 in osteoblasts alters bone mechanical properties.
Q59137465Effect of Total Flavonoids of on Tibial Dyschondroplasia by Regulating BMP-2 and Runx2 Expression in Chickens
Q38829110Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B.
Q37033816Expression of Runx2 transcription factor in non-skeletal tissues, sperm and brain
Q37137454FGF2 stimulation of the pyrophosphate-generating enzyme, PC-1, in pre-osteoblast cells is mediated by RUNX2.
Q42428362Functional analysis of novel RUNX2 mutations in cleidocranial dysplasia
Q37365273Inducible expression of Runx2 results in multiorgan abnormalities in mice.
Q36600824Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism
Q28476413Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis
Q92377245Molecular Mechanism of Runx2-Dependent Bone Development
Q28542439Osteoblast-specific deletion of Pkd2 leads to low-turnover osteopenia and reduced bone marrow adiposity
Q28541582Osteocyte-specific deletion of Fgfr1 suppresses FGF23
Q90729095Osteoporosis: Mechanism, Molecular Target, and Current Status on Drug Development
Q35004670Polyalanine repeat polymorphism in RUNX2 is associated with site-specific fracture in post-menopausal females
Q36585580Polycystin-1 regulates skeletogenesis through stimulation of the osteoblast-specific transcription factor RUNX2-II.
Q37623787Protein kinase inhibitor SU6668 attenuates positive regulation of Gli proteins in cancer and multipotent progenitor cells
Q37325296RUNX2 mutations in Chinese patients with cleidocranial dysplasia.
Q33787937Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells
Q36616577Runx2 and dental development
Q35314247Runx2 protein expression utilizes the Runx2 P1 promoter to establish osteoprogenitor cell number for normal bone formation
Q48194394Runx2, an inducer of osteoblast and chondrocyte differentiation.
Q34227055Runx2-I isoform contributes to fetal bone formation even in the absence of specific N-terminal amino acids
Q34333682Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice
Q50896849Systems level analysis of osteoclastogenesis reveals intrinsic and extrinsic regulatory interactions.
Q28588867Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton.
Q37667523The differentially DNA-methylated region responsible for expression of runt-related transcription factor 2.
Q38903594Thymosin beta 4 is associated with RUNX2 expression through the Smad and Akt signaling pathways in mouse dental epithelial cells
Q35895390Transforming growth factor beta signaling in adult cardiovascular diseases and repair.

Search more.