The effect of 2,2'-substitution on the metabolism and toxicity of dapsone in vitro and in vivo.

scientific article published in March 1998

The effect of 2,2'-substitution on the metabolism and toxicity of dapsone in vitro and in vivo. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S1382-6689(97)10070-9
P698PubMed publication ID21781861

P50authorMalcolm D. TingleQ40627513
Steve WardQ55112735
P2093author name stringB K Park
M D Coleman
R Mahmud
J L Maggs
S Hawley
P2860cites workThe Dapsone SyndromeQ56387626
Structural basis for the haemotoxicity of dapsone: the importance of the sulphonyl groupQ62232369
The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: Chemical mechanisms and the effects of fluorine substitutionQ62232414
The Protective Effect of Vitamin E on the Hemolysis Associated With Dapsone Treatment in Patients With Dermatitis HerpetiformisQ67753001
Quantitative structure-activity relationships of the metabolism of drugs by uridine diphosphate glucuronosyltransferaseQ67842602
Characterization of paracetamol UDP-glucuronosyltransferase activity in human liver microsomesQ68348236
Mechanism of methemoglobin formation by diphenylsulfones. Effect of 4-amino-4'-hydroxyaminodiphenylsulfone and other p-substituted derivativesQ70405638
Dapsone-pyrimethamine compared with aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia and toxoplasmosis in HIV infection. The PRIO Study GroupQ70674006
Dapsone-induced agranulocytosis: spontaneous reporting dataQ72850580
Studies on the inhibitory effects of analogues of dapsone on neutrophil function in-vitroQ73272483
Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular modelQ26778456
Dapsone Suppresses Integrin-Mediated Neutrophil Adherence FunctionQ28324430
Designing safer chemicals: predicting the rates of metabolism of halogenated alkanesQ33754400
Inhibition of the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase by dapsoneQ34237109
Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymesQ34397894
Molecular genetics of the P-450 superfamilyQ38140202
Clinical pharmacokinetics of dapsoneQ39743290
Utility of dapsone for prophylaxis of Pneumocystis carinii pneumonia in trimethoprim-sulfamethoxazole-intolerant, HIV-infected individualsQ40720382
Generalized cytochrome P450-mediated oxidation and oxygenation reactions in aromatic substrates with activated N-H, O-H, C-H, or S-H substituentsQ40767687
Studies on the toxicity of analogues of dapsone in-vitro using rat, human and heterologously expressed metabolizing systemsQ40927959
N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicityQ42000770
The use of a three compartment in vitro model to investigate the role of hepatic drug metabolism in drug-induced blood dyscrasiasQ43201438
N-hydroxylation of 4,4'-diaminodiphenylsulphone (Dapsone) by liver microsomes, and in dogs and humansQ44004288
Antimalarial agents. 7. Compounds related to 4,4'-bis(aminophenyl) sulfoneQ47958149
Antimalarial agents. 8. Ring-substituted bis(4-aminophenyl) sulfones and their precursorsQ47958617
Strategic approaches to drug design. I. An integrated software framework for molecular modellingQ50149089
Radioactive tracer studies on uptake of di-amino-diphenyl-sulphone by leprosy patients.Q52774768
Biochemical effects of aromatic amines. I. Methaemoglobinaemia, haemolysis and Heinz-body formation induced by 4,4'-diaminodiphenylsulphone.Q54196851
Quantitative structure-activity analysis in dihydropteroate synthase inhibition by sulfones. Comparison with sulfanilamides.Q54766806
P433issue2
P921main subjectdapsoneQ422226
P304page(s)145-153
P577publication date1998-03-01
P1433published inEnvironmental Toxicology and PharmacologyQ15724489
P1476titleThe effect of 2,2'-substitution on the metabolism and toxicity of dapsone in vitro and in vivo
P478volume5

Reverse relations

Q40822890Preliminary in vitro toxicological evaluation of a series of 2-pyridylcarboxamidrazone candidate anti-tuberculosis compoundscites workP2860

Search more.