Riluzole synergizes with paclitaxel to inhibit cell growth and induce apoptosis in triple-negative breast cancer.

scientific article published on 5 August 2017

Riluzole synergizes with paclitaxel to inhibit cell growth and induce apoptosis in triple-negative breast cancer. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10549-017-4435-X
P8608Fatcat IDrelease_brxkgdevhva73drptdmsiaweii
P932PMC publication ID6886242
P698PubMed publication ID28780701

P50authorDavid GorskiQ16729388
P2093author name stringCecilia L Speyer
Sudeshna Bandyopadhyay
Miriam A Bukhsh
Waris S Jafry
Rachael E Sexton
P2860cites workThe ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferationQ24678674
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signalingQ27851446
Microtubules as a target for anticancer drugsQ28253993
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapiesQ29617680
ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.Q30176115
A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulinQ30999913
A phase 0 trial of riluzole in patients with resectable stage III and IV melanomaQ33616544
A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade?Q34104378
Triple Negative Breast Cancer - An OverviewQ34274285
Riluzole mediates anti-tumor properties in breast cancer cells independent of metabotropic glutamate receptor-1.Q34525011
Triple-negative breast cancer: clinical features and patterns of recurrenceQ34658655
Standard of care and promising new agents for triple negative metastatic breast cancerQ34774884
Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast cancerQ35007438
Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancerQ35122078
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.Q35757521
Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypesQ37269261
Metabotropic glutamate receptor-1 contributes to progression in triple negative breast cancerQ37431333
Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancerQ37502074
Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cellsQ37626431
The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cellsQ37731451
The 2014 Society of Surgical Oncology Susan G. Komen for the Cure Symposium: triple-negative breast cancerQ38295108
Riluzole enhances ionizing radiation-induced cytotoxicity in human melanoma cells that ectopically express metabotropic glutamate receptor 1 in vitro and in vivo.Q39591407
Activation of a nuclear factor kappaB/interleukin-1 positive feedback loop by amphiregulin in human breast cancer cellsQ40099297
Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma ProgressionQ42009322
Molecular characterization of EGFR and EGFR-downstream pathways in triple negative breast carcinomas with basal like featuresQ42504459
Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor.Q43512515
Bcl-2 and BLIMP-1 expression predict worse prognosis in gastric diffuse large B cell lymphoma (DLCBL) while other markers for nodal DLBCL are not useful.Q43816514
Enhanced endogenous type I interferon cell-driven survival and inhibition of spontaneous apoptosis by RiluzoleQ44597587
Riluzole induces apoptotic cell death in human prostate cancer cells via endoplasmic reticulum stress.Q45968193
Protein kinase C-{alpha} mediates epidermal growth factor receptor transactivation in human prostate cancer cellsQ46493494
Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytesQ46843527
A novel neuroprotective mechanism of riluzole: direct inhibition of protein kinase C.Q55034186
RiluzoleQ56483801
The problem of synergism and antagonism of combined drugsQ73248616
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcell growthQ189159
paclitaxelQ423762
P304page(s)407-419
P577publication date2017-08-05
P1433published inBreast Cancer Research and TreatmentQ326085
P1476titleRiluzole synergizes with paclitaxel to inhibit cell growth and induce apoptosis in triple-negative breast cancer
P478volume166

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cites work (P2860)
Q64276226ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia
Q58098917Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer
Q92705179Repurposing Potential of Riluzole as an ITAF Inhibitor in mTOR Therapy Resistant Glioblastoma

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