The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells

scientific article published on 27 May 2010

The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1050730656
P356DOI10.1038/JID.2010.126
P932PMC publication ID4004181
P698PubMed publication ID20505744
P5875ResearchGate publication ID44633401

P2093author name stringKarine A Cohen-Solal
James S Goydos
Stephen A Rosenberg
Adam S Nabatian
Joseph L-K Chan
Kim T Merrigan
Maithao N Le
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A phase 0 trial of riluzole in patients with resectable stage III and IV melanomaQ33616544
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Vasculogenic mimicry and tumour-cell plasticity: lessons from melanomaQ35141769
Identification and functional roles of metabotropic glutamate receptor-interacting proteinsQ35764025
Molecular biology and ontogeny of glutamate receptors in the mammalian central nervous systemQ35821619
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The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanomaQ36170391
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The future of tyrosine kinase inhibitors: single agent or combination?Q37258971
Genetic subgrouping of melanoma reveals new opportunities for targeted therapyQ37436761
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Cutaneous malignant melanoma: ESMO clinical recommendations for diagnosis, treatment and follow-upQ37488998
Treatment for metastatic malignant melanoma: old drugs and new strategiesQ37603597
Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCepsilonQ40348200
Focal adhesion kinase promotes the aggressive melanoma phenotype.Q40355320
Metabotropic glutamate receptors promote neuronal and vascular plasticity through novel intracellular pathwaysQ44266379
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).Q44586345
New ideas for therapy in ALS.Q46612559
Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasiaQ48250298
U0126, a mitogen-activated protein kinase kinase inhibitor, inhibits the invasion of human A375 melanoma cells.Q53754222
A novel neuroprotective mechanism of riluzole: direct inhibition of protein kinase C.Q55034186
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)Q58255477
A comparison of the pharmacokinetics and tolerability of riluzole after repeat dose administration in healthy elderly and young volunteersQ77422002
Riluzole for ALS: what is the evidence?Q95785711
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectcell migrationQ189092
P304page(s)2240-2249
P577publication date2010-05-27
P1433published inJournal of Investigative DermatologyQ3186921
P1476titleThe glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells
P478volume130

Reverse relations

cites work (P2860)
Q49907440A phase II trial of riluzole, an antagonist of metabotropic glutamate receptor 1 (GRM1) signaling, in patients with advanced melanoma
Q33560677Activation of the glutamate receptor GRM1 enhances angiogenic signaling to drive melanoma progression
Q93109246Concurrent Targeting of Glutaminolysis and Metabotropic Glutamate Receptor 1 (GRM1) Reduces Glutamate Bioavailability in GRM1+ Melanoma
Q98226242Discovery of a Novel Hybrid of Vorinostat and Riluzole as a Potent Antitumor Agent
Q37626431Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells
Q92640761Effectiveness assessment of riluzole in the prevention of oxaliplatin-induced peripheral neuropathy: RILUZOX-01: protocol of a randomised, parallel, controlled, double-blind and multicentre study by the UNICANCER-AFSOS Supportive Care intergroup
Q38681744Exploiting ROS and metabolic differences to kill cisplatin resistant lung cancer
Q36409682Functional effects of GRM1 suppression in human melanoma cells
Q37121338Glutamate signaling in benign and malignant disorders: current status, future perspectives, and therapeutic implications
Q39168954Glutamatergic pathway targeting in melanoma: single-agent and combinatorial therapies
Q30570451Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells
Q38971337Metabotropic glutamate receptor 1 acts as a dependence receptor creating a requirement for glutamate to sustain the viability and growth of human melanomas
Q34904277Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes
Q35122078Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer
Q36170150Molecular pathways: dysregulated glutamatergic signaling pathways in cancer
Q34450728Non-canonical Smads phosphorylation induced by the glutamate release inhibitor, riluzole, through GSK3 activation in melanoma
Q36288488Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole
Q91596457Osteosarcoma growth suppression by riluzole delivery via iron oxide nanocage in nude mice
Q33697210RUNX2 is overexpressed in melanoma cells and mediates their migration and invasion
Q34525011Riluzole mediates anti-tumor properties in breast cancer cells independent of metabotropic glutamate receptor-1.
Q47986792Riluzole synergizes with paclitaxel to inhibit cell growth and induce apoptosis in triple-negative breast cancer.
Q30528073Serum glutamate levels correlate with Gleason score and glutamate blockade decreases proliferation, migration, and invasion and induces apoptosis in prostate cancer cells
Q37608810Studies of Secondary Melanoma on C57BL/6J Mouse Liver Using 1H NMR Metabolomics
Q42009322Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression
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Q36997763Triple threat treatment: Exploiting the dependence receptor properties of metabotropic glutamate receptor 1 against melanoma
Q52312423[The cancer paradigm in pulmonary arterial hypertension: towards anti-remodeling therapies targeting metabolic dysfunction?]

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