Signaling from the IL-2 receptor to the nucleus

scientific article published in December 1997

Signaling from the IL-2 receptor to the nucleus is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S1359-6101(97)00021-X
P698PubMed publication ID9620644

P2093author name stringW J Leonard
J X Lin
P2860cites workPerinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase SykQ24303475
Human growth hormone and extracellular domain of its receptor: crystal structure of the complexQ24308045
Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptorQ24313035
A family of cytokine-inducible inhibitors of signallingQ24313168
A new protein containing an SH2 domain that inhibits JAK kinasesQ24313242
Identification and purification of human Stat proteins activated in response to interleukin-2Q24314547
Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferationQ24316156
Development and function of T cells in mice rendered interleukin-2 deficient by gene targetingQ24318910
Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4Q24323130
Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptorQ24323187
Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptorQ24323232
Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA'sQ24339580
The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignmentQ24611277
Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteinsQ24652745
Jak-STAT signaling induced by the v-abl oncogeneQ41292981
Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain.Q41294941
Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoproteinQ41326706
PI3K: downstream AKTion blocks apoptosisQ41351876
The state of the STATs: recent developments in the study of signal transduction to the nucleusQ41382841
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptorQ41429389
Functional dissection of p56lck, a protein tyrosine kinase which mediates interleukin-2-induced activation of the c-fos geneQ41444083
Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signallingQ41450864
Heterodimerization of the IL-2 receptor beta- and gamma-chain cytoplasmic domains is required for signallingQ41466961
Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation.Q41466988
Cell type-specific tyrosine phosphorylation of IL-2 receptor beta chain in response to IL-2.Q41602814
Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7Q24679411
Protein modules and signalling networksQ27860694
STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc inductionQ28236871
The IFN gamma receptor: a paradigm for cytokine receptor signalingQ28237623
Transcription factors of the NFAT family: regulation and functionQ28237645
Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCIDQ28241595
Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunitsQ28241606
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cellsQ28244421
Identification of a ten-amino acid proline-rich SH3 binding siteQ28266446
Cloning of the gamma chain of the human IL-2 receptorQ28284261
Immunopharmacology of rapamycinQ28285198
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)Q28296501
Functional analysis of the human interleukin 2 receptor gamma chain gene promoterQ28299407
Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complexQ28299971
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinaseQ28320515
Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lckQ28511623
Molecular cloning of cDNAs for the rat interleukin 2 receptor alpha and beta chain genes: differentially regulated gene activity in response to mitogenic stimulationQ28567594
Structure and function of a new STAT-induced STAT inhibitorQ28584775
Syk tyrosine kinase required for mouse viability and B-cell developmentQ28586985
Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartmentQ28587823
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 geneQ28593669
Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathwayQ28610817
Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexesQ28647290
Modular binding domains in signal transduction proteinsQ29617351
Jaks and STATs: biological implicationsQ29619657
The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell lineQ30194303
Interleukin 2- and polyomavirus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytesQ30450318
Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular associationQ34115915
Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.Q34195443
Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.Q34288951
Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.Q34307135
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.Q34329668
Selective in Vitro Growth of T Lymphocytes from Normal Human Bone MarrowsQ34734344
New insights into T-cell antigen receptor structure and signal transductionQ35453567
IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-mycQ41614199
Signal transduction by interleukin 2 in human T cells: Activation of tyrosine and ribosomal S6 kinases and cell‐cycle regulatory genesQ41627670
Differential effects of interleukin-2 and interleukin-4 on protein tyrosine phosphorylation in factor-dependent murine T cellsQ41734607
An associated molecule, p64, with high-affinity interleukin 2 receptorQ41755746
Contrasting interleukin 2 binding properties of the alpha (p55) and beta (p70) protein subunits of the human high-affinity interleukin 2 receptorQ41865277
Pseudo-high affinity interleukin 2 (IL-2) receptor lacks the third component that is essential for functional IL-2 binding and signalingQ42108520
Response of resting human peripheral blood natural killer cells to interleukin 2.Q42153962
Expression of Tac antigen on activated normal human B cellsQ42937105
The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulationQ42941998
Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditionsQ43534297
Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosisQ43539775
Structure of the human interleukin-2 receptor geneQ43579120
Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genesQ44579187
Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humansQ45874932
Molecular cloning of cDNA encoding human interleukin-2 receptorQ48386784
Molecular cloning and expression of cDNAs for the human interleukin-2 receptorQ48386792
Developmental defects of lymphoid cells in Jak3 kinase-deficient mice.Q52204302
Human NK resistant tumor cell lysis is effected by IL-2 activated killer cells.Q54462041
Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product.Q55242465
HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor.Q55242466
Immune responses in interleukin-2-deficient miceQ58194363
Interleukins 4 and 5 control expression of IL-2 receptor on murine B cells through independent induction of its two chainsQ58997874
A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptorsQ59068448
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptorQ59068757
Recombinant interleukin-2 directly augments the cytotoxicity of human monocytesQ59076874
Human interleukin-2 promotes proliferation of activated B cells via surface receptors similar to those of activated T cellsQ59087233
The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIVQ69827093
A model system for peptide hormone action in differentiation: interleukin 2 induces a B lymphoma to transcribe the J chain geneQ70311891
Proliferation of human peripheral blood lymphocytes induced by recombinant human interleukin 2: contribution of large granular lymphocytes and T lymphocytesQ70320292
The IL-2 receptor beta chain (p70): role in mediating signals for LAK, NK, and proliferative activitiesQ70361166
Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3Q71542082
Defective lymphoid development in mice lacking Jak3Q71542089
T cell deletion in high antigen dose therapy of autoimmune encephalomyelitisQ71611171
Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytesQ71665305
Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor betaQ72287439
Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinaseQ73363088
An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain inductionQ73925273
Temporal sequence and cellular origin of interleukin-2 stimulated cytokine gene expressionQ35976007
Kinetic analysis of ligand binding to interleukin-2 receptor complexes created on an optical biosensor surfaceQ36279572
Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigenQ36349541
Activated B cells express receptors for, and proliferate in response to, pure interleukin 2.Q36349546
Expression of interleukin 2 receptors on activated human B cellsQ36349561
Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesisQ36349713
Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cellsQ36350420
Expression and role of p75 interleukin 2 receptor on human monocytesQ36351122
Interleukin 2 high-affinity receptor expression requires two distinct binding proteinsQ36352421
Interleukin 2 activates extracellular signal-regulated protein kinase 2.Q36362418
Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptorQ36363861
Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cellsQ36367193
The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasisQ36376720
Molecular cloning and structure of the human interleukin 2 receptor geneQ36424232
Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathwayQ36551314
Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha geneQ36564177
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.Q36566823
The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor beta-chain promoter through noncanonical Egr and Sp1 binding sitesQ36569096
Cloning, sequence and expression of human interleukin-2 receptorQ36587211
Structure and expression of a cloned cDNA for human interleukin-2.Q36603382
Multiple Cytokines Stimulate the Binding of a Common 145-Kilodalton Protein to Shc at the Grb2 Recognition Site of ShcQ36668147
Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell lineQ36703252
Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene productsQ36823531
Regulation of human T-lymphocyte gene expression by interleukin 2: immediate-response genes include the proto-oncogene c-mybQ36833691
Recombinant interleukin 2 regulates levels of c-myc mRNA in a cloned murine T lymphocyteQ36952516
Molecular interactions, T-cell subsets and a role of the CD4/CD8:p56lck complex in human T-cell activationQ38262262
Mouse interleukin-2 receptor alpha gene expression. Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elementsQ38295569
The multi-subunit interleukin-2 receptorQ38686728
The interleukin 2 receptorQ38737587
Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-IQ39250459
A Regulatory Element in the Human Interleukin 2 Gene Promoter Is a Binding Site for the Zinc Finger Proteins Sp1 and EGR-1Q39469566
Developmental abnormalities in mice transgenic for bovine oncostatin M.Q40016116
Protease activation during apoptosis: death by a thousand cuts?Q40459802
Cytokine signaling through nonreceptor protein tyrosine kinasesQ40506447
Sharing of a common gamma chain, gamma c, by the IL-2, IL-4, and IL-7 receptors: implications for X-linked severe combined immunodeficiency (XSCID).Q40610994
Signal transduction by the B cell antigen receptor and its coreceptorsQ40661147
IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levelsQ40976868
Structural and functional diversity of phosphoinositide 3-kinases.Q40998279
P433issue4
P304page(s)313-332
P577publication date1997-12-01
P1433published inCytokine and Growth Factor ReviewsQ15763303
P1476titleSignaling from the IL-2 receptor to the nucleus
P478volume8

Reverse relations

cites work (P2860)
Q38734677Acetylation Modulates IL-2 Receptor Signaling in T Cells
Q33915748Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping
Q49256041Adenine Nucleotides Attenuate Murine T Cell Activation Induced by Concanavalin A or T Cell Receptor Stimulation
Q28212401Alternate signalling pathways from the interleukin-2 receptor
Q44219218Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling
Q44223669Arginine butyrate increases the cytotoxicity of DAB(389)IL-2 in leukemia and lymphoma cells by upregulation of IL-2Rbeta gene
Q46737891Atorvastatin affects interleukin-2 signaling by altering the lipid raft enrichment of the interleukin-2 receptor beta chain
Q33964298Binding of HMG-I(Y) imparts architectural specificity to a positioned nucleosome on the promoter of the human interleukin-2 receptor alpha gene
Q24294683CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function
Q34118698CCR5 expression levels influence NFAT translocation, IL-2 production, and subsequent signaling events during T lymphocyte activation
Q31123164CD40 activation rescues antiviral CD8⁺ T cells from PD-1-mediated exhaustion.
Q28145666CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling
Q28282872CISH and susceptibility to infectious diseases
Q34625889Calcium mobilization is both required and sufficient for initiating chromatin decondensation during activation of peripheral T-cells
Q40691071Carboxy-terminal truncated STAT5 is induced by interleukin-2 and GM-CSF in human neutrophils
Q24338625Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP)
Q34513296Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence
Q40804313Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells
Q39600705Control of IL-2Ralpha gene expression: structural changes within the proximal enhancer/core promoter during T-cell development
Q36384702Critical role for Rsk2 in T-lymphocyte activation
Q46425499Daclizumab therapy in kidney transplantation-different mechanisms of action in- versus ex-vivo?
Q34464999Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta
Q53625986Dendritic cell derived IL-2 inhibits survival of terminally mature cells via an autocrine signaling pathway.
Q33860989Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells.
Q33742099Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells
Q28185990Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells
Q39338915Dynamic Long-Range Chromatin Interaction Controls Expression of IL-21 in CD4+ T Cells.
Q30305586Essential role for the C-terminal noncatalytic region of SHIP in FcgammaRIIB1-mediated inhibitory signaling
Q35346411FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma
Q22001449Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling
Q24522782Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation
Q36179796GB virus C envelope protein E2 inhibits TCR-induced IL-2 production and alters IL-2-signaling pathways
Q30832554Genome wide transcriptional analysis of resting and IL2 activated human natural killer cells: gene expression signatures indicative of novel molecular signaling pathways
Q37502276How diverse--CD4 effector T cells and their functions
Q39659675IL-2 Induces Conformational Changes in Its Preassembled Receptor Core, Which Then Migrates in Lipid Raft and Binds to the Cytoskeleton Meshwork
Q33902174IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells.
Q28219286IL-2 receptor signaling through the Shb adapter protein in T and NK cells
Q80455481IL-2Rbeta links IL-2R signaling with Foxp3 expression
Q46824244Identification of a novel G245R polymorphism in the IL-2 receptor beta membrane proximal domain associated with human visceral leishmaniasis.
Q38170857Immunosuppressive peptides and their therapeutic applications.
Q44104890Inhibition of the IL-15 pathway in anti-CD25 mAb treated renal allograft recipients
Q34568715Interleukin-2 and interleukin-15: immunotherapy for cancer.
Q33917765Interleukin-2 receptor downstream events in regulatory T cells: implications for the choice of immunosuppressive drug therapy
Q36971446Interleukin-2 receptor signaling in regulatory T cell development and homeostasis
Q33888375Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice
Q43590297Long-term regulation of Na,K-ATPase pump during T-cell proliferation
Q30723840Mechanism of Janus kinase 3-catalyzed phosphorylation of a Janus kinase 1 activation loop peptide
Q24805826Moderate exercise may attenuate some aspects of immunosenescence
Q24610882Molecular mechanism of interleukin-2-induced mucosal homeostasis
Q35012607Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets
Q21184104NetPath: a public resource of curated signal transduction pathways
Q43948616Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor
Q93048503Relationship between Multiple Sclerosis-Associated IL2RA Risk Allele Variants and Circulating T Cell Phenotypes in Healthy Genotype-Selected Controls
Q40748015Reversible CD8 expression induced by common cytokine receptor gamma chain-dependent cytokines in a cloned CD4(+) T(h)1 cell line
Q41428122Shikonin Suppresses Human T Lymphocyte Activation through Inhibition of IKK β Activity and JNK Phosphorylation
Q34170866Signaling via the IL-2 and IL-7 receptors from the membrane to the nucleus
Q54649629Smad-dependent cooperative regulation of interleukin 2 receptor alpha chain gene expression by T cell receptor and transforming growth factor-beta.
Q28140287Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation
Q28586849Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity
Q43949091Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation.
Q36719234T-cell development and function are modulated by dual specificity phosphatase DUSP5
Q35674513The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis
Q37001930The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation
Q40049468The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice
Q90407993The RNA-Binding Protein HuR Posttranscriptionally Regulates IL-2 Homeostasis and CD4+ Th2 Differentiation
Q48349941The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements
Q34089393The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements
Q38995167The contribution of interleukin-2 to effective wound healing
Q33941389The role of Stat5a and Stat5b in signaling by IL-2 family cytokines
Q36563513The roles for cytokines in the generation and maintenance of regulatory T cells
Q33957422The significance of tetramerization in promoter recruitment by Stat5.
Q43552812Treatment with the chimeric anti-IL-2Ralpha basiliximab affects both the IL-2 and IL-15 signalling pathways after clinical kidney transplantation
Q52666501Tubulin polymerization modulates interleukin-2 receptor signal transduction in human T cells.
Q41852651Type I diabetes-associated tolerogenic properties of interleukin-2.
Q40846875Use of chimeric receptor molecules to dissect signal transduction mechanisms

Search more.