review article | Q7318358 |
scholarly article | Q13442814 |
P356 | DOI | 10.1016/S1359-6101(97)00021-X |
P698 | PubMed publication ID | 9620644 |
P2093 | author name string | W J Leonard | |
J X Lin | |||
P2860 | cites work | Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk | Q24303475 |
Human growth hormone and extracellular domain of its receptor: crystal structure of the complex | Q24308045 | ||
Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor | Q24313035 | ||
A family of cytokine-inducible inhibitors of signalling | Q24313168 | ||
A new protein containing an SH2 domain that inhibits JAK kinases | Q24313242 | ||
Identification and purification of human Stat proteins activated in response to interleukin-2 | Q24314547 | ||
Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation | Q24316156 | ||
Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting | Q24318910 | ||
Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4 | Q24323130 | ||
Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor | Q24323187 | ||
Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor | Q24323232 | ||
Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's | Q24339580 | ||
The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment | Q24611277 | ||
Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins | Q24652745 | ||
Jak-STAT signaling induced by the v-abl oncogene | Q41292981 | ||
Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain. | Q41294941 | ||
Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein | Q41326706 | ||
PI3K: downstream AKTion blocks apoptosis | Q41351876 | ||
The state of the STATs: recent developments in the study of signal transduction to the nucleus | Q41382841 | ||
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor | Q41429389 | ||
Functional dissection of p56lck, a protein tyrosine kinase which mediates interleukin-2-induced activation of the c-fos gene | Q41444083 | ||
Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signalling | Q41450864 | ||
Heterodimerization of the IL-2 receptor beta- and gamma-chain cytoplasmic domains is required for signalling | Q41466961 | ||
Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation. | Q41466988 | ||
Cell type-specific tyrosine phosphorylation of IL-2 receptor beta chain in response to IL-2. | Q41602814 | ||
Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7 | Q24679411 | ||
Protein modules and signalling networks | Q27860694 | ||
STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction | Q28236871 | ||
The IFN gamma receptor: a paradigm for cytokine receptor signaling | Q28237623 | ||
Transcription factors of the NFAT family: regulation and function | Q28237645 | ||
Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID | Q28241595 | ||
Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits | Q28241606 | ||
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells | Q28244421 | ||
Identification of a ten-amino acid proline-rich SH3 binding site | Q28266446 | ||
Cloning of the gamma chain of the human IL-2 receptor | Q28284261 | ||
Immunopharmacology of rapamycin | Q28285198 | ||
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID) | Q28296501 | ||
Functional analysis of the human interleukin 2 receptor gamma chain gene promoter | Q28299407 | ||
Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex | Q28299971 | ||
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase | Q28320515 | ||
Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck | Q28511623 | ||
Molecular cloning of cDNAs for the rat interleukin 2 receptor alpha and beta chain genes: differentially regulated gene activity in response to mitogenic stimulation | Q28567594 | ||
Structure and function of a new STAT-induced STAT inhibitor | Q28584775 | ||
Syk tyrosine kinase required for mouse viability and B-cell development | Q28586985 | ||
Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment | Q28587823 | ||
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene | Q28593669 | ||
Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway | Q28610817 | ||
Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes | Q28647290 | ||
Modular binding domains in signal transduction proteins | Q29617351 | ||
Jaks and STATs: biological implications | Q29619657 | ||
The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line | Q30194303 | ||
Interleukin 2- and polyomavirus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytes | Q30450318 | ||
Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association | Q34115915 | ||
Localization of the gene encoding the human interleukin-2 receptor on chromosome 10. | Q34195443 | ||
Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. | Q34288951 | ||
Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. | Q34307135 | ||
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. | Q34329668 | ||
Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows | Q34734344 | ||
New insights into T-cell antigen receptor structure and signal transduction | Q35453567 | ||
IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc | Q41614199 | ||
Signal transduction by interleukin 2 in human T cells: Activation of tyrosine and ribosomal S6 kinases and cell‐cycle regulatory genes | Q41627670 | ||
Differential effects of interleukin-2 and interleukin-4 on protein tyrosine phosphorylation in factor-dependent murine T cells | Q41734607 | ||
An associated molecule, p64, with high-affinity interleukin 2 receptor | Q41755746 | ||
Contrasting interleukin 2 binding properties of the alpha (p55) and beta (p70) protein subunits of the human high-affinity interleukin 2 receptor | Q41865277 | ||
Pseudo-high affinity interleukin 2 (IL-2) receptor lacks the third component that is essential for functional IL-2 binding and signaling | Q42108520 | ||
Response of resting human peripheral blood natural killer cells to interleukin 2. | Q42153962 | ||
Expression of Tac antigen on activated normal human B cells | Q42937105 | ||
The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation | Q42941998 | ||
Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions | Q43534297 | ||
Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis | Q43539775 | ||
Structure of the human interleukin-2 receptor gene | Q43579120 | ||
Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes | Q44579187 | ||
Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans | Q45874932 | ||
Molecular cloning of cDNA encoding human interleukin-2 receptor | Q48386784 | ||
Molecular cloning and expression of cDNAs for the human interleukin-2 receptor | Q48386792 | ||
Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. | Q52204302 | ||
Human NK resistant tumor cell lysis is effected by IL-2 activated killer cells. | Q54462041 | ||
Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product. | Q55242465 | ||
HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor. | Q55242466 | ||
Immune responses in interleukin-2-deficient mice | Q58194363 | ||
Interleukins 4 and 5 control expression of IL-2 receptor on murine B cells through independent induction of its two chains | Q58997874 | ||
A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors | Q59068448 | ||
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor | Q59068757 | ||
Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes | Q59076874 | ||
Human interleukin-2 promotes proliferation of activated B cells via surface receptors similar to those of activated T cells | Q59087233 | ||
The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV | Q69827093 | ||
A model system for peptide hormone action in differentiation: interleukin 2 induces a B lymphoma to transcribe the J chain gene | Q70311891 | ||
Proliferation of human peripheral blood lymphocytes induced by recombinant human interleukin 2: contribution of large granular lymphocytes and T lymphocytes | Q70320292 | ||
The IL-2 receptor beta chain (p70): role in mediating signals for LAK, NK, and proliferative activities | Q70361166 | ||
Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3 | Q71542082 | ||
Defective lymphoid development in mice lacking Jak3 | Q71542089 | ||
T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis | Q71611171 | ||
Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes | Q71665305 | ||
Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta | Q72287439 | ||
Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase | Q73363088 | ||
An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction | Q73925273 | ||
Temporal sequence and cellular origin of interleukin-2 stimulated cytokine gene expression | Q35976007 | ||
Kinetic analysis of ligand binding to interleukin-2 receptor complexes created on an optical biosensor surface | Q36279572 | ||
Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen | Q36349541 | ||
Activated B cells express receptors for, and proliferate in response to, pure interleukin 2. | Q36349546 | ||
Expression of interleukin 2 receptors on activated human B cells | Q36349561 | ||
Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis | Q36349713 | ||
Stable expression of cDNA encoding the human interleukin 2 receptor in eukaryotic cells | Q36350420 | ||
Expression and role of p75 interleukin 2 receptor on human monocytes | Q36351122 | ||
Interleukin 2 high-affinity receptor expression requires two distinct binding proteins | Q36352421 | ||
Interleukin 2 activates extracellular signal-regulated protein kinase 2. | Q36362418 | ||
Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor | Q36363861 | ||
Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells | Q36367193 | ||
The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis | Q36376720 | ||
Molecular cloning and structure of the human interleukin 2 receptor gene | Q36424232 | ||
Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway | Q36551314 | ||
Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene | Q36564177 | ||
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. | Q36566823 | ||
The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor beta-chain promoter through noncanonical Egr and Sp1 binding sites | Q36569096 | ||
Cloning, sequence and expression of human interleukin-2 receptor | Q36587211 | ||
Structure and expression of a cloned cDNA for human interleukin-2. | Q36603382 | ||
Multiple Cytokines Stimulate the Binding of a Common 145-Kilodalton Protein to Shc at the Grb2 Recognition Site of Shc | Q36668147 | ||
Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line | Q36703252 | ||
Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products | Q36823531 | ||
Regulation of human T-lymphocyte gene expression by interleukin 2: immediate-response genes include the proto-oncogene c-myb | Q36833691 | ||
Recombinant interleukin 2 regulates levels of c-myc mRNA in a cloned murine T lymphocyte | Q36952516 | ||
Molecular interactions, T-cell subsets and a role of the CD4/CD8:p56lck complex in human T-cell activation | Q38262262 | ||
Mouse interleukin-2 receptor alpha gene expression. Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements | Q38295569 | ||
The multi-subunit interleukin-2 receptor | Q38686728 | ||
The interleukin 2 receptor | Q38737587 | ||
Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I | Q39250459 | ||
A Regulatory Element in the Human Interleukin 2 Gene Promoter Is a Binding Site for the Zinc Finger Proteins Sp1 and EGR-1 | Q39469566 | ||
Developmental abnormalities in mice transgenic for bovine oncostatin M. | Q40016116 | ||
Protease activation during apoptosis: death by a thousand cuts? | Q40459802 | ||
Cytokine signaling through nonreceptor protein tyrosine kinases | Q40506447 | ||
Sharing of a common gamma chain, gamma c, by the IL-2, IL-4, and IL-7 receptors: implications for X-linked severe combined immunodeficiency (XSCID). | Q40610994 | ||
Signal transduction by the B cell antigen receptor and its coreceptors | Q40661147 | ||
IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels | Q40976868 | ||
Structural and functional diversity of phosphoinositide 3-kinases. | Q40998279 | ||
P433 | issue | 4 | |
P304 | page(s) | 313-332 | |
P577 | publication date | 1997-12-01 | |
P1433 | published in | Cytokine and Growth Factor Reviews | Q15763303 |
P1476 | title | Signaling from the IL-2 receptor to the nucleus | |
P478 | volume | 8 |
Q38734677 | Acetylation Modulates IL-2 Receptor Signaling in T Cells |
Q33915748 | Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping |
Q49256041 | Adenine Nucleotides Attenuate Murine T Cell Activation Induced by Concanavalin A or T Cell Receptor Stimulation |
Q28212401 | Alternate signalling pathways from the interleukin-2 receptor |
Q44219218 | Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling |
Q44223669 | Arginine butyrate increases the cytotoxicity of DAB(389)IL-2 in leukemia and lymphoma cells by upregulation of IL-2Rbeta gene |
Q46737891 | Atorvastatin affects interleukin-2 signaling by altering the lipid raft enrichment of the interleukin-2 receptor beta chain |
Q33964298 | Binding of HMG-I(Y) imparts architectural specificity to a positioned nucleosome on the promoter of the human interleukin-2 receptor alpha gene |
Q24294683 | CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function |
Q34118698 | CCR5 expression levels influence NFAT translocation, IL-2 production, and subsequent signaling events during T lymphocyte activation |
Q31123164 | CD40 activation rescues antiviral CD8⁺ T cells from PD-1-mediated exhaustion. |
Q28145666 | CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling |
Q28282872 | CISH and susceptibility to infectious diseases |
Q34625889 | Calcium mobilization is both required and sufficient for initiating chromatin decondensation during activation of peripheral T-cells |
Q40691071 | Carboxy-terminal truncated STAT5 is induced by interleukin-2 and GM-CSF in human neutrophils |
Q24338625 | Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP) |
Q34513296 | Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence |
Q40804313 | Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells |
Q39600705 | Control of IL-2Ralpha gene expression: structural changes within the proximal enhancer/core promoter during T-cell development |
Q36384702 | Critical role for Rsk2 in T-lymphocyte activation |
Q46425499 | Daclizumab therapy in kidney transplantation-different mechanisms of action in- versus ex-vivo? |
Q34464999 | Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta |
Q53625986 | Dendritic cell derived IL-2 inhibits survival of terminally mature cells via an autocrine signaling pathway. |
Q33860989 | Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells. |
Q33742099 | Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells |
Q28185990 | Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells |
Q39338915 | Dynamic Long-Range Chromatin Interaction Controls Expression of IL-21 in CD4+ T Cells. |
Q30305586 | Essential role for the C-terminal noncatalytic region of SHIP in FcgammaRIIB1-mediated inhibitory signaling |
Q35346411 | FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma |
Q22001449 | Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling |
Q24522782 | Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation |
Q36179796 | GB virus C envelope protein E2 inhibits TCR-induced IL-2 production and alters IL-2-signaling pathways |
Q30832554 | Genome wide transcriptional analysis of resting and IL2 activated human natural killer cells: gene expression signatures indicative of novel molecular signaling pathways |
Q37502276 | How diverse--CD4 effector T cells and their functions |
Q39659675 | IL-2 Induces Conformational Changes in Its Preassembled Receptor Core, Which Then Migrates in Lipid Raft and Binds to the Cytoskeleton Meshwork |
Q33902174 | IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells. |
Q28219286 | IL-2 receptor signaling through the Shb adapter protein in T and NK cells |
Q80455481 | IL-2Rbeta links IL-2R signaling with Foxp3 expression |
Q46824244 | Identification of a novel G245R polymorphism in the IL-2 receptor beta membrane proximal domain associated with human visceral leishmaniasis. |
Q38170857 | Immunosuppressive peptides and their therapeutic applications. |
Q44104890 | Inhibition of the IL-15 pathway in anti-CD25 mAb treated renal allograft recipients |
Q34568715 | Interleukin-2 and interleukin-15: immunotherapy for cancer. |
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Q36971446 | Interleukin-2 receptor signaling in regulatory T cell development and homeostasis |
Q33888375 | Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice |
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Q35012607 | Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets |
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Q43948616 | Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor |
Q93048503 | Relationship between Multiple Sclerosis-Associated IL2RA Risk Allele Variants and Circulating T Cell Phenotypes in Healthy Genotype-Selected Controls |
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Q34170866 | Signaling via the IL-2 and IL-7 receptors from the membrane to the nucleus |
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Q43949091 | Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation. |
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