Interleukin-2 receptor downstream events in regulatory T cells: implications for the choice of immunosuppressive drug therapy

scientific article

Interleukin-2 receptor downstream events in regulatory T cells: implications for the choice of immunosuppressive drug therapy is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.4161/CC.7.4.5454
P932PMC publication ID2886808
P698PubMed publication ID18235249
P5875ResearchGate publication ID5617249

P50authorRobert S. NegrinQ110528996
P2093author name stringRobert Zeiser
P2860cites workFOXP3 controls regulatory T cell function through cooperation with NFATQ24298179
Development and function of T cells in mice rendered interleukin-2 deficient by gene targetingQ24318910
Immunopharmacology of rapamycinQ28285198
Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartmentQ28587823
Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytesQ32024520
Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cellsQ33742099
Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitroQ33942128
Interleukin 2 signaling involves the phosphorylation of Stat proteinsQ34007160
Fluticasone propionate increases CD4CD25 T regulatory cell suppression of allergen-stimulated CD4CD25 T cells by an IL-10-dependent mechanismQ34341871
Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance.Q34516841
Interleukin 2 signaling is required for CD4(+) regulatory T cell functionQ34527240
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.Q34554035
IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patientsQ34657691
CD4+ CD25+ suppressor T cells: more questions than answersQ34716304
PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ TregsQ34997285
IL-2, regulatory T cells, and toleranceQ35700529
Nonredundant roles for Stat5a/b in directly regulating Foxp3Q35828667
TNF downmodulates the function of human CD4+CD25hi T-regulatory cellsQ35849817
Tolerance, not immunity, crucially depends on IL-2.Q35877199
Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferationQ36026082
Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivoQ36100451
Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cellsQ36384673
Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD).Q36384836
Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cellsQ37317866
CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergyQ40397533
Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 productionQ41908710
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivoQ42139164
Molecular mechanisms underlying FOXP3 induction in human T cellsQ42491664
Sirolimus versus cyclosporine therapy increases circulating regulatory T cells, but does not protect renal transplant patients given alemtuzumab induction from chronic allograft injury.Q42636572
Physiological sphingosine 1-phosphate requirement for optimal activity of mouse CD4+ regulatory T CellsQ44844822
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.Q45299244
Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patientsQ45864185
Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance.Q45889459
Tacrolimus versus cyclosporine induction therapy in pulmonary transplantation in miniature swineQ46627243
Circulating and thymic CD4 CD25 T regulatory cells in myasthenia gravis: effect of immunosuppressive treatmentQ46657338
Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cellsQ46739924
The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activityQ46844009
Effect of immunosuppressants on the expansion and function of naturally occurring regulatory T cellsQ46898362
Clinical trial: switch to combined mycophenolate mofetil and minimal dose calcineurin inhibitor in stable liver transplant patients--assessment of renal and allograft function, cardiovascular risk factors and immune monitoringQ46943584
Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor functionQ47579310
Signaling from the IL-2 receptor to the nucleusQ47992419
Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell deathQ48020712
Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma.Q51996007
IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.Q51998742
A potential side effect of cyclosporin A: inhibition of CD4(+)CD25(+) regulatory T cells in mice.Q53583176
Increased spontaneous apoptosis of CD4+CD25+ T cells in patients with active rheumatoid arthritis is reduced by infliximab.Q53659586
Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cellsQ56901500
The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+ CD25- T cellsQ56901651
Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycinQ56901703
Regulatory T Cells and T Cell Depletion: Role of Immunosuppressive DrugsQ57702564
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2Q74660381
Upregulation of Foxp3 expression in mouse and human Treg is IL-2/STAT5 dependent: implications for the NOD STAT5B mutation in diabetes pathogenesisQ79386860
Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ TQ79834605
Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+ CD25+ FoxP3+ T cellsQ79919091
A Foxy tango with NFATQ80149222
Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipientsQ80154346
Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTENQ80283949
Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 geneQ80833054
The structure of interleukin-2 complexed with its alpha receptorQ81810296
Overcoming T cell-mediated rejection of bone marrow allografts by T-regulatory cells: synergism with veto cells and rapamycinQ83853617
P433issue4
P921main subjectinterleukinsQ194908
P304page(s)458-462
P577publication date2007-12-18
P1433published inCell CycleQ1254166
P1476titleInterleukin-2 receptor downstream events in regulatory T cells: implications for the choice of immunosuppressive drug therapy
P478volume7

Reverse relations

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