Histone/protein deacetylases and T-cell immune responses

scientific article published on 12 January 2012

Histone/protein deacetylases and T-cell immune responses is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1182/BLOOD-2011-10-292003
P932PMC publication ID3311271
P698PubMed publication ID22246031
P5875ResearchGate publication ID221748328

P50authorUlf H BeierQ59006483
P2093author name stringWayne W Hancock
Liqing Wang
Yujie Liu
Tatiana Akimova
P2860cites workEpigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?Q83125659
Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cellsQ83176706
Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skinQ84307121
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repressionQ24300168
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domainQ24311550
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexesQ24338109
The many roles of histone deacetylases in development and physiology: implications for disease and therapyQ24628821
MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery componentsQ24648543
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylationQ24649964
Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissuesQ24670176
The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responsesQ24796904
Lysine acetylation targets protein complexes and co-regulates major cellular functionsQ27860589
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor gamma functionQ28508365
Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cellsQ28511811
HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damageQ28569045
Valproic acid attenuates inflammation in experimental autoimmune neuritisQ28575981
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and menQ29619117
Acetylation and deacetylation of non-histone proteinsQ29619636
Epigenetic control of the foxp3 locus in regulatory T cellsQ33273617
Specific activity of class II histone deacetylases in human breast cancer cellsQ33606021
Class II histone deacetylases: from sequence to function, regulation, and clinical implicationQ33724483
Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosisQ33828002
Interleukin-2 receptor downstream events in regulatory T cells: implications for the choice of immunosuppressive drug therapyQ33917765
Helios expression is a marker of T cell activation and proliferation.Q34019821
Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ TregsQ34050126
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cellsQ34617154
Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodiesQ34652570
Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival.Q34742199
Histone deacetylase inhibitors for treating a spectrum of diseases not related to cancerQ35016934
HDAC inhibition in lupus modelsQ35016981
HDAC inhibition and graft versus host diseaseQ35016985
Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytesQ35034012
DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitinationQ35048728
STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunctionQ35061825
Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cellsQ35096555
The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2Q35160462
An epigenetic view of helper T cell differentiationQ35164202
CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers gameQ35178495
Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells.Q35300659
Histone deacetylase 9 deficiency protects against effector T cell-mediated systemic autoimmunityQ35309505
Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cellsQ35990736
Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice.Q36014379
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylasesQ36141408
Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transitionQ36421122
p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cellsQ36489810
High TCR stimuli prevent induced regulatory T cell differentiation in a NF-κB-dependent mannerQ36530189
HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen.Q36534267
TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3.Q36893657
Histone deacetylase cytoplasmic trapping by a novel fluorescent HDAC inhibitorQ36963764
CD4+ T-regulatory cells: toward therapy for human diseases.Q37211300
HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells.Q37340316
At the crossroads of T helper lineage commitment-Epigenetics points the way.Q37375215
Using histone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft toleranceQ37378417
Histone deacetylases: salesmen and customers in the post-translational modification market.Q37389553
Regulatory T cells overturned: the effectors fight backQ37412624
Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824.Q37426386
T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiationQ37478410
Plasticity of CD4(+) FoxP3(+) T cellsQ37509592
Histone deacetylase inhibitors: current status and overview of recent clinical trialsQ37595483
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cellsQ37621254
Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells.Q37632479
Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg functionQ37792465
Inhibition of histone deacetylases in inflammatory bowel diseasesQ37848684
Function of histone deacetylase inhibitors in inflammation.Q37899219
Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progressionQ39247455
Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs.Q39502973
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.Q39765588
HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2.Q39952254
Histone deacetylase inhibitors induce antigen specific anergy in lymphocytes: a comparative studyQ40287945
Rapid alteration of microRNA levels by histone deacetylase inhibitionQ40322140
Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cellsQ40439850
Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytesQ40687886
Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cellsQ40835298
Acetylation of RNA Processing Proteins and Cell Cycle Proteins in MitosisQ42136568
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.Q42163084
Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritisQ42571975
CBP/p300 histone acetyl-transferase activity is important for the G1/S transitionQ42801428
MS-275, an histone deacetylase inhibitor, reduces the inflammatory reaction in rat experimental autoimmune neuritisQ43069570
Histone deacetylase inhibitor uses p21(Cip1) to maintain anergy in CD4+ T cellsQ43296075
Histone deacetylase inhibitors: a new class of immunosuppressors targeting a novel signal pathway essential for CD154 expressionQ44189598
Discrete roles for histone acetylation in human T helper 1 cell-specific gene expressionQ44997621
Induction of Foxp3+ regulatory T cells with histone deacetylase inhibitorsQ46055067
DNA methylation controls Foxp3 gene expressionQ46391168
Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cellsQ46490320
Histone deacetylases: novel targets for prevention of colitis-associated cancer in miceQ46808312
T cell tolerance induced by histone deacetylase inhibitor is mediated by P21cip1.Q46910831
Deacetylase inhibition promotes the generation and function of regulatory T cells.Q46961808
Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1.Q47765824
Cytoplasmic sequestration of HDAC7 from mitochondrial and nuclear compartments upon initiation of apoptosisQ47927518
T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genesQ50111962
Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene.Q51045931
Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions.Q51765584
Expansion of activated human naïve T-cells precedes effector function.Q52009198
Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1.Q52932701
Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells.Q53613759
Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitmentQ56879954
Transient expression of FOXP3 in human activated nonregulatory CD4+ T cellsQ58234949
The Effect of Smoking on the Transcriptional Regulation of Lung Inflammation in Patients with Chronic Obstructive Pulmonary DiseaseQ58317005
Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipientsQ80154346
P433issue11
P407language of work or nameEnglishQ1860
P1104number of pages9
P304page(s)2443-2451
P577publication date2012-01-12
P1433published inBloodQ885070
P1476titleHistone/protein deacetylases and T-cell immune responses
P478volume119

Reverse relations

cites work (P2860)
Q38217594Cellular immunotherapy strategies for Ewing sarcoma
Q39055861Challenges and opportunities for checkpoint blockade in T-cell lymphoproliferative disorders
Q38924569Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy
Q41885967Comparison of HDAC inhibitors in clinical development: effect on HIV production in latently infected cells and T-cell activation
Q26998898Developing Combined HIV Vaccine Strategies for a Functional Cure
Q35818676Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4+Foxp3+ Regulatory T Cells
Q42463384Effect of histone deacetylase inhibitor JNJ-26481585 in pain
Q54504613Effects of histone deacetylase inhibitors on alloresponses.
Q38096822Eliminating the latent HIV reservoir by reactivation strategies: advancing to clinical trials
Q38431356Emerging approaches for histone deacetylase inhibitor drug discovery
Q39142245Epigenetic Alterations in Cellular Immunity: New Insights into Autoimmune Diseases
Q36357400Epigenetic drugs: a novel anti-aging strategy?
Q38838643Epigenetic modifiers in immunotherapy: a focus on checkpoint inhibitors
Q88453278Epigenetics of Aberrant Cardiac Wound Healing
Q26772330Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response
Q37082640Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
Q37490660Global state measures of the dentate gyrus gene expression system predict antidepressant-sensitive behaviors
Q34379613HDAC1 controls CD8+ T cell homeostasis and antiviral response
Q33566569HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function
Q57143889Histone deacetylase function in CD4 T cells
Q35029450Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans
Q38763747Histone deacetylase inhibitors as immunomodulators in cancer therapeutics
Q27324527Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes
Q42815246Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model.
Q34647217Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses
Q38240733Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
Q64914861Immunoepigenetics Combination Therapies: An Overview of the Role of HDACs in Cancer Immunotherapy.
Q38866711Impact of acetylation on tumor metabolism.
Q96155591Inhibition of Histone Deacetylase (HDAC) Enhances Checkpoint Blockade Efficacy by Rendering Bladder Cancer Cells Visible for T Cell-Mediated Destruction
Q64120396MEF-2 isoforms' (A-D) roles in development and tumorigenesis
Q92071968Metabolic Control of Epigenetics and Its Role in CD8+ T Cell Differentiation and Function
Q97518968Metabolic Reprogramming in CD8+ T Cells During Acute Viral Infections
Q92173163NAD-linked mechanisms of gene de-repression and a novel role for CtBP in persistent adenovirus infection of lymphocytes
Q38727211Promising Role of Toll-Like Receptor 8 Agonist in Concert with Prostratin for Activation of Silent HIV.
Q30579284Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators
Q40081751Reolysin and Histone Deacetylase Inhibition in the Treatment of Head and Neck Squamous Cell Carcinoma
Q36115749SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells
Q36525896Sequential treatment with 5-aza-2'-deoxycytidine and deacetylase inhibitors reactivates HIV-1.
Q30275552Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-γ.
Q39575774T cell signaling targets for enhancing regulatory or effector function
Q57712790Targeting transcription factor lysine acetylation in inflammatory airway diseases
Q37034469The Effect of Latency Reversal Agents on Primary CD8+ T Cells: Implications for Shock and Kill Strategies for Human Immunodeficiency Virus Eradication
Q47975522The Effects of Histone Deacetylase Inhibition on the Levels of Cerebral Cytokines in an Animal Model of Mania Induced by Dextroamphetamine
Q28076473The Impact of Chemotherapy, Radiation and Epigenetic Modifiers in Cancer Cell Expression of Immune Inhibitory and Stimulatory Molecules and Anti-Tumor Efficacy
Q35673349The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding
Q37144949The differential short- and long-term effects of HIV-1 latency-reversing agents on T cell function
Q36361960The effect of Ingenol-B on the suppressive capacity of elite suppressor HIV-specific CD8+ T cells.
Q64099722The emerging role of epigenetics in human autoimmune disorders
Q24294822The functional interactome landscape of the human histone deacetylase family
Q37326217Valproic acid ameliorates coxsackievirus-B3-induced viral myocarditis by modulating Th17/Treg imbalance
Q34541123Vorinostat eliminates multicellular resistance of mesothelioma 3D spheroids via restoration of Noxa expression

Search more.