HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage

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HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage is …
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scholarly articleQ13442814

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P356DOI10.1038/NN.2471
P3181OpenCitations bibliographic resource ID3330430
P932PMC publication ID2829989
P698PubMed publication ID20037577
P5875ResearchGate publication ID40786323

P50authorPatrizia CasacciaQ63315510
P2093author name stringRichard Reynolds
Jin Young Kim
Siming Shen
Ye He
Karen Dietz
Owain Howell
P2860cites workThe bovine herpesvirus 1 immediate-early protein (bICP0) associates with histone deacetylase 1 to activate transcriptionQ24291697
HDAC6 is a microtubule-associated deacetylaseQ24298013
Mutations in the neurofilament light gene linked to Charcot-Marie-Tooth disease cause defects in transportQ24300855
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stressQ24301895
Glutamate excitotoxicity in a model of multiple sclerosisQ60450917
Kinesin-mediated transport of neurofilament protein oligomers in growing axonsQ73087769
Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammationQ73822019
Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosisQ80112328
Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cellsQ24529064
Histone deacetylases (HDACs): characterization of the classical HDAC familyQ24535587
Regulation of transcription factor YY1 by acetylation and deacetylationQ24550859
Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelinationQ24627168
The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nervesQ24806766
Regulation of neuronal traits by a novel transcriptional complexQ28214009
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivoQ28510434
Identification of a signal for rapid export of proteins from the nucleusQ29547742
Axonal transection in the lesions of multiple sclerosisQ29615585
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNAQ29620175
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiencyQ30052479
Impaired axonal transport and altered axolemmal permeability occur in distinct populations of damaged axons following traumatic brain injuryQ30434742
Class II histone deacetylases: from sequence to function, regulation, and clinical implicationQ33724483
Neuroprotection by histone deacetylase-related proteinQ34564841
The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damageQ36299396
Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synucleinQ36677512
Pathogenesis of axonal and neuronal damage in multiple sclerosisQ36840382
Mechanisms of neuronal damage in multiple sclerosis and its animal models: role of calcium pumps and exchangersQ36979460
Histone deacetylase inhibitors prevent p53-dependent and p53-independent Bax-mediated neuronal apoptosis through two distinct mechanismsQ37169993
Diffuse axonal injury in non-missile head injuryQ37274633
Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosisQ37398059
Axonal transport defects in neurodegenerative diseasesQ37614744
Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons.Q39100374
Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylationQ40152899
Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3.Q40634789
Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cellsQ40693659
Phosphorylation-related immunoreactivity and the rate of transport of neurofilaments in chronic 2,5-hexanedione intoxicationQ41138743
Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptorsQ41612066
Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neuronsQ41644415
Dephosphorylation of neurofilament proteins enhances their susceptibility to degradation by calpainQ42000714
Axonopathy and transport deficits early in the pathogenesis of Alzheimer's diseaseQ42474769
Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5.Q44365117
Flavopiridol and histone deacetylase inhibitors promote mitochondrial injury and cell death in human leukemia cells that overexpress Bcl-2.Q44914263
Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin proteinQ45290027
Lysolecithin induces demyelination in vitro in a cerebellar slice culture system.Q46157039
Imaging correlates of axonal swelling in chronic multiple sclerosis brainsQ48207806
Neocortical neuronal, synaptic, and glial loss in multiple sclerosisQ48413281
Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death.Q48732598
Axonal damage in acute multiple sclerosis lesionsQ48776354
Demyelination increases radial diffusivity in corpus callosum of mouse brainQ48908359
Increased calpain I-mediated proteolysis, and preferential loss of dephosphorylated NF200, following traumatic spinal cord injuryQ57839879
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)180-189
P577publication date2009-12-27
P1433published inNature NeuroscienceQ1535359
P1476titleHDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage
P478volume13

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cites work (P2860)
Q28577939A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus
Q39248784A focus on the preclinical development and clinical status of the histone deacetylase inhibitor, romidepsin (depsipeptide, Istodax(®)).
Q37384508A trifluoromethyl analogue of celecoxib exerts beneficial effects in neuroinflammation
Q47603807ABIN1 inhibits HDAC1 ubiquitination and protects it from both proteasome- and lysozyme-dependent degradation.
Q36818194Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease
Q27307057Age-related memory impairment is associated with disrupted multivariate epigenetic coordination in the hippocampus
Q36635673Antiretroviral neurotoxicity
Q30391351Astaxanthin ameliorates prenatal LPS-exposed behavioral deficits and oxidative stress in adult offspring.
Q57562094Axonal Loss and Neurofilament Phosphorylation Changes Accompany Lesion Development and Clinical Progression in Multiple Sclerosis
Q35126104Axonal damage in multiple sclerosis.
Q34570124Axonal degeneration in multiple sclerosis: can we predict and prevent permanent disability?
Q43026728Beneficial effects of minocycline on cuprizone induced cortical demyelination
Q37787304Benefits of histone deacetylase inhibitors for acute brain injury: a systematic review of animal studies.
Q41063803Bioenergetic Failure in Rat Oligodendrocyte Progenitor Cells Treated with Cerebrospinal Fluid Derived from Multiple Sclerosis Patients
Q42464099Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelination in vivo.
Q35836163C. elegans model of neuronal aging
Q64056936Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1
Q34422726Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics
Q46468122Chronic demyelination-induced seizures
Q49884282Complex neuroprotective and neurotoxic effects of histone deacetylases.
Q24618949Current and future pharmacological treatment strategies in X-linked adrenoleukodystrophy
Q28576128Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter
Q35829521Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination
Q47265472Disturbed Glucose Metabolism in Rat Neurons Exposed to Cerebrospinal Fluid Obtained from Multiple Sclerosis Subjects
Q92755669Epigenetic Alterations Induced by Photothrombotic Stroke in the Rat Cerebral Cortex: Deacetylation of Histone h3, Upregulation of Histone Deacetylases and Histone Acetyltransferases
Q36948933Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment
Q34323841Epigenetic memory: the Lamarckian brain
Q35791723Epigenetic regulation of axon and dendrite growth
Q37381853Epigenetic regulation of sensory axon regeneration after spinal cord injury
Q33693885Epigenetics and the environment: in search of the "toleroasome" vital to execution of ischemic preconditioning
Q26995255Epigenetics of neural repair following spinal cord injury
Q36870458Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes
Q93016306Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport
Q46255661Experimental autoimmune encephalomyelitis from a tissue energy perspective.
Q47926939Expression of Class I Histone Deacetylases in Ipsilateral and Contralateral Hemispheres after the Focal Photothrombotic Infarction in the Mouse Brain
Q37285451Flow-induced HDAC1 phosphorylation and nuclear export in angiogenic sprouting.
Q37685428HDAC inhibitors and neurodegeneration: at the edge between protection and damage
Q39829692HDAC1 in axonal degeneration: A matter of subcellular localization
Q94686423HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo
Q35581098HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum
Q36103678HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration
Q28080593Histone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration
Q92927460Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery?
Q34179757Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter
Q36347335Histone deacetylase inhibitors preserve function in aging axons
Q36318929Histone deacetylase-1 (HDAC1) is a molecular switch between neuronal survival and death
Q28575131Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children
Q35849307Histone/protein deacetylases and T-cell immune responses
Q37921168How histone deacetylases control myelination
Q35053115Identification of an intrinsic determinant critical for maspin subcellular localization and function.
Q33918201Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors.
Q93049244Implications of Diet and The Gut Microbiome in Neuroinflammatory and Neurodegenerative Diseases
Q55428388Inhibition of Histone Deacetylases Attenuates Morphine Tolerance and Restores MOR Expression in the DRG of BCP Rats.
Q34536980Insights into neuroepigenetics through human histone deacetylase PET imaging.
Q38543597Intracellular Protein Shuttling: A Mechanism Relevant for Myelin Repair in Multiple Sclerosis?
Q38215303Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors
Q38749124Ionomycin-induced calcium influx induces neurite degeneration in mouse neuroblastoma cells: analysis of a time-lapse live cell imaging system
Q37368725Lithium down-regulates histone deacetylase 1 (HDAC1) and induces degradation of mutant huntingtin.
Q59129045Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse model
Q38196701Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis.
Q35572468Mitochondria: key players in the neurotoxic effects of amphetamines.
Q28566372Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration
Q34077393Mitogen-activated protein kinase phosphatase 3 (MKP-3)-deficient mice are resistant to diet-induced obesity
Q48354362Molecular Genetic and Epigenetic Basis of Multiple Sclerosis
Q91910728Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis
Q41942567Multiple sclerosis patient-derived CSF induces transcriptional changes in proliferating oligodendrocyte progenitors
Q47122034Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease
Q38812938Myelin Basic Protein Citrullination in Multiple Sclerosis: A Potential Therapeutic Target for the Pathology
Q30538837NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats
Q50495025NEX-TRAP, a novel method for in vivo analysis of nuclear export of proteins.
Q50026944Neurodegeneration in Progressive Multiple Sclerosis.
Q82616710Neurodegeneration: export disrupts transport
Q26824369Novel protective effects of histone deacetylase inhibition on stroke and white matter ischemic injury
Q35910495Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination
Q38534982Oligodendrocytes: Myelination and Axonal Support
Q28486241Oxidative stress and proinflammatory cytokines contribute to demyelination and axonal damage in a cerebellar culture model of neuroinflammation
Q59800027PKCε phosphorylation regulates the mitochondrial translocation of ATF2 in ischemia-induced neurodegeneration
Q92489483Pathogenic mechanisms of neurodegeneration based on the phenotypic expression of progressive forms of immune-mediated neurologic disease
Q92608702Polymeric sheet actuators with programmable bioinstructivity
Q48460212Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury
Q92221378Promoter conservation in HDACs points to functional implications
Q41872258Promoting return of function in multiple sclerosis: An integrated approach
Q90689022RNA-binding protein altered expression and mislocalization in MS
Q34544950Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology
Q82659772Renegade nuclear enzymes disrupt axonal integrity
Q38305861Reshaping the chromatin landscape after spinal cord injury
Q36539447Signaling Over Distances
Q37734207Signals to promote myelin formation and repair
Q82602601Slowly Progressive Axonal Degeneration in a Rat Model of Chronic, Nonimmune-Mediated Demyelination
Q64082973Structural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site
Q38701633Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation.
Q36453005Subcellular Localization of Class I Histone Deacetylases in the Developing Xenopus tectum
Q41877371Suppression of immunodeficiency virus-associated neural damage by the p75 neurotrophin receptor ligand, LM11A-31, in an in vitro feline model
Q41578052The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology
Q39351825The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.
Q38239792The central role of mitochondria in axonal degeneration in multiple sclerosis
Q91983661The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program to control neurite outgrowth
Q37820143The tale of protein lysine acetylation in the cytoplasm.
Q92241239Therapeutic Effect of the Mitochondria-Targeted Antioxidant SkQ1 on the Culture Model of Multiple Sclerosis
Q36906420Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss
Q38156341Transcription and beyond: the role of mammalian class I lysine deacetylases
Q52667681Trichostatin A and Sirtinol Regulate the Expression and Nucleocytoplasmic Shuttling of Histone Deacetylases in All-Trans Retinoic Acid-Induced Differentiation of Neuroblastoma Cells.
Q35733643Understanding neurological disease mechanisms in the era of epigenetics
Q38087145Unique functional roles for class I and class II histone deacetylases in central nervous system development and function
Q48107874Visual experience dependent regulation of neuronal structure and function by histone deacetylase 1 in developing Xenopus tectum in vivo.
Q35126078Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination

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