Structural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site

Structural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-019-43004-0
P932PMC publication ID6488578
P698PubMed publication ID31036839

P2093author name stringNick V Grishin
Jimin Pei
Yoonji Lee
Yuh Min Chook
Jordan M Baumhardt
P2860cites workGapped BLAST and PSI-BLAST: a new generation of protein database search programsQ24545170
Structural basis for leucine-rich nuclear export signal recognition by CRM1Q24604395
Structural Basis of Targeting the Exportin CRM1 in CancerQ26781513
Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTPQ27655147
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1Q27665346
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
Protein secondary structure prediction based on position-specific scoring matricesQ27860483
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.Q27939311
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAsQ28131708
HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damageQ28569045
The SWISS-MODEL Repository-new features and functionalityQ28584445
Backrub-like backbone simulation recapitulates natural protein conformational variability and improves mutant side-chain predictionQ28914743
Identification of a signal for rapid export of proteins from the nucleusQ29547742
CRM1 is responsible for intracellular transport mediated by the nuclear export signalQ29547861
CD-Search: protein domain annotations on the flyQ29615328
Analysis and prediction of leucine-rich nuclear export signalsQ29619228
Evidence for a role of CRM1 in signal-mediated nuclear protein exportQ29620231
DISOPRED3: precise disordered region predictions with annotated protein-binding activityQ30633989
Nuclear export signal consensus sequences defined using a localization-based yeast selection systemQ33371970
UniRef clusters: a comprehensive and scalable alternative for improving sequence similarity searchesQ34447998
A Pareto-optimal refinement method for protein design scaffoldsQ34657875
Prediction of leucine-rich nuclear export signal containing proteins with NESsentialQ35198286
NESmapper: accurate prediction of leucine-rich nuclear export signals using activity-based profilesQ35261339
LocNES: a computational tool for locating classical NESs in CRM1 cargo proteinsQ35541125
Nuclear transport and cancer: from mechanism to interventionQ35633427
Structural determinants of nuclear export signal orientation in binding to exportin CRM1.Q36132392
NESdb: a database of NES-containing CRM1 cargoesQ36234505
Sequence and structural analyses of nuclear export signals in the NESdb databaseQ36234511
ValidNESs: a database of validated leucine-rich nuclear export signalsQ36491242
Relaxation of backbone bond geometry improves protein energy landscape modelingQ37480774
Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.Q37712229
Improving protein disorder prediction by deep bidirectional long short-term memory recurrent neural networks.Q39067587
ProViz-a web-based visualization tool to investigate the functional and evolutionary features of protein sequencesQ39845548
Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutantsQ42826742
Prediction of nuclear export signals using weighted regular expressions (Wregex).Q47681206
NoLogo: a new statistical model highlights the diversity and suggests new classes of Crm1-dependent nuclear export signals.Q50317533
Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization.Q55265811
IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding.Q55518742
Correlation of CRM1-NES affinity with nuclear export activityQ59358372
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)6627
P577publication date2019-04-29
P1433published inScientific ReportsQ2261792
P1476titleStructural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site
P478volume9

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