Importins and exportins: how to get in and out of the nucleus

scientific article published in May 1998

Importins and exportins: how to get in and out of the nucleus is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0968-0004(98)01204-3
P698PubMed publication ID9612083

P50authorKarsten WeisQ37375543
P2860cites workA nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathwayQ24309825
Identification of a tRNA-specific nuclear export receptorQ24314506
Export of importin alpha from the nucleus is mediated by a specific nuclear transport factorQ24316152
Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factorQ24321853
Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteinsQ24321880
A human nucleoporin-like protein that specifically interacts with HIV RevQ24322635
A novel receptor-mediated nuclear protein import pathwayQ24324050
A cap-binding protein complex mediating U snRNA exportQ24336104
The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein importQ24563136
A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleusQ24563147
A nuclear localization domain in the hnRNP A1 proteinQ24672627
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
A distinct nuclear import pathway used by ribosomal proteinsQ27929963
Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleusQ27932000
Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteinsQ27932702
Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeastQ27933981
Importin/karyopherin protein family members required for mRNA export from the nucleusQ27934542
A distinct and parallel pathway for the nuclear import of an mRNA-binding proteinQ27938430
A nuclear import pathway for a protein involved in tRNA maturationQ27938639
Exportin 1 (Crm1p) is an essential nuclear export factorQ27939696
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAsQ28131708
The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear exportQ28254641
Identification of a nuclear export receptor for tRNAQ28265348
Nucleocytoplasmic transportQ28275907
The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteinsQ28278924
Identification of a signal for rapid export of proteins from the nucleusQ29547742
CRM1 is responsible for intracellular transport mediated by the nuclear export signalQ29547861
Nucleocytoplasmic transport: signals, mechanisms and regulationQ29547904
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleusQ29616325
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNAQ29620175
Evidence for a role of CRM1 in signal-mediated nuclear protein exportQ29620231
Identification and functional analysis of the nuclear localization signals of ribosomal protein L25 from Saccharomyces cerevisiaeQ33407107
Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1Q34065588
Isolation and characterization of Saccharomyces cerevisiae mRNA transport-defective (mtr) mutantsQ36234509
Nucleocytoplasmic recycling of the nuclear localization signal receptor alpha subunit in vivo is dependent on a nuclear export signal, energy, and RCC1Q36273838
A role for the M9 transport signal of hnRNP A1 in mRNA nuclear exportQ36274062
Inhibition of mRNA export in vertebrate cells by nuclear export signal conjugatesQ36816824
Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificitiesQ41079130
Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein exportQ41104206
Differential expression and sequence-specific interaction of karyopherin alpha with nuclear localization sequencesQ41127829
Nuclear import of U snRNPs requires importin betaQ42632635
RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleusQ42772140
Importin provides a link between nuclear protein import and U snRNA exportQ48059143
P433issue5
P1104number of pages5
P304page(s)185-189
P577publication date1998-05-01
P1433published inTrends in Biochemical SciencesQ1565711
P1476titleImportins and exportins: how to get in and out of the nucleus
P478volume23

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cites work (P2860)
Q28294475A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization
Q34034754A functional nuclear localization sequence in the C. elegans TRPV channel OCR-2.
Q24313327A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling
Q38325567A potential NES of the Epstein-Barr virus nuclear antigen 1 (EBNA1) does not confer shuttling
Q27931572A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue
Q40898947A rev-like NES mediates cytoplasmic localization of HERV-K cORF.
Q33889690A tripartite nuclear localization signal in the PDZ-domain protein L-periaxin
Q36421285Active nuclear import and export is independent of lumenal Ca2+ stores in intact mammalian cells
Q36861198Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast
Q33650478All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners
Q27657690An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation
Q44567843An N-terminal segment of the active component of the bacterial genotoxin cytolethal distending toxin B (CDTB) directs CDTB into the nucleus
Q42224835An RNA recognition motif mediates the nucleocytoplasmic transport of a trypanosome RNA-binding protein.
Q24538586Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery
Q33940712Atomic basis of CRM1-cargo recognition, release and inhibition
Q34107063Bioinformatic Analysis of Differential Protein Expression in Calu-3 Cells Exposed to Carbon Nanotubes
Q35919908Birth, death, and replacement of karyopherins in Drosophila
Q40742771Both ran and importins have the ability to function as nuclear mRNA export factors
Q54646381Cellular localization of human p53 expressed in the yeast Saccharomyces cerevisiae: effect of NLSI deletion.
Q35570765Centrosomes and kinetochores, who needs 'Em? The role of noncentromeric chromatin in spindle assembly
Q40756616Characterization of an unusual importin alpha binding motif in the borna disease virus p10 protein that directs nuclear import
Q40758360Characterization of the nuclear export signal of polypyrimidine tract-binding protein
Q42830005Characterization of the nuclear import and export mechanisms of bovine herpesvirus-1 infected cell protein 27.
Q24682707Chromosomal proteins HMG-14 and HMG-17 are released from mitotic chromosomes and imported into the nucleus by active transport
Q28611955Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C
Q41823951Copper induces cytoplasmic retention of fission yeast transcription factor cuf1.
Q35058103Crystal structure of human importin-α1 (Rch1), revealing a potential autoinhibition mode involving homodimerization
Q27931758Cse1p is required for export of Srp1p/importin-alpha from the nucleus in Saccharomyces cerevisiae
Q74638201Definition of a consensus transportin-specific nucleocytoplasmic transport signal
Q24682912Determination of the functional domain organization of the importin alpha nuclear import factor
Q40846853Directing proteins to nucleus by fusion to nuclear localization signal tags
Q43508477Dissection of a nuclear localization signal
Q40910811Distinct energy requirement for nuclear import and export of importin beta in living cells
Q34173417Distinct ion channel classes are expressed on the outer nuclear envelope of T- and B-lymphocyte cell lines
Q34615049Drosophila melanogaster importin alpha1 and alpha3 can replace importin alpha2 during spermatogenesis but not oogenesis
Q49963024Effects of different extracts of curcumin on TPC1 papillary thyroid cancer cell line.
Q34998360Effects of mutations in the adenoviral E1B 55-kilodalton protein coding sequence on viral late mRNA metabolism.
Q41113075Expanding the definition of the classical bipartite nuclear localization signal
Q24531945Export and transport of tRNA are coupled to a multi-protein complex
Q29614387Finding nuclear localization signals
Q28361515Heat shock protein 90 and the nuclear transport of progesterone receptor
Q30497051Identification and functional analysis of NOL7 nuclear and nucleolar localization signals
Q33647302Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.
Q28580253Identification of nuclear import and export signals within the structure of the zinc finger protein TIS11
Q43698338Identification of nuclei associated proteins by 2D-gel electrophoresis and mass spectrometry
Q39529269Identification of p53 sequence elements that are required for MDM2-mediated nuclear export
Q46068635Identification, analysis, and use of nuclear export signals in Saccharomyces cerevisiae
Q90681995Impact of Respiratory Syncytial Virus Infection on the Host Cell: Implications for Antiviral Strategies
Q33692823Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor
Q74236761Importin alpha binds to an unusual bipartite nuclear localization signal in the heterogeneous ribonucleoprotein type I
Q40829562Importin beta is a mitotic target of the small GTPase Ran in spindle assembly
Q24805778Importin-beta-like nuclear transport receptors
Q33597374In or out? Regulating nuclear transport
Q89700428Inhibiting cancer cell hallmark features through nuclear export inhibition
Q33938174Kinetic analysis of translocation through nuclear pore complexes
Q47927759Left ventricle transcriptomic analysis reveals connective tissue accumulation associates with initial age-dependent decline in V̇o2peak from its lifetime apex
Q42660117Localization of the 26S proteasome during mitosis and meiosis in fission yeast
Q27932044Mex67p mediates nuclear export of a variety of RNA polymerase II transcripts.
Q85055431Molecular determinants responsible for the subcellular localization of HSV-1 UL4 protein
Q37106762Multiple vesiculoviral matrix proteins inhibit both nuclear export and import
Q41954995NSP-interacting GTPase: A cytosolic protein as cofactor for nuclear shuttle proteins.
Q33716338Nuclear exclusion of transcription factors associated with apoptosis in developing nervous tissue
Q43428742Nuclear export in plants. Use of geminivirus movement proteins for a cell-based export assay
Q27930028Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p.
Q47889024Nuclear export of proteins in plants: AtXPO1 is the export receptor for leucine-rich nuclear export signals in Arabidopsis thaliana
Q34679479Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor
Q34465441Nuclear export: DNA-binding domains find a surprising partner
Q34310369Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae
Q28143161Nuclear localization and transactivating capacities of the papillary renal cell carcinoma-associated TFE3 and PRCC (fusion) proteins
Q36745203Nuclear tRNA aminoacylation and its role in nuclear export of endogenous tRNAs in Saccharomyces cerevisiae
Q40933908Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression
Q24539168Nuclear transport: run by Ran?
Q33836817Nucleocytoplasmic shuttling by human immunodeficiency virus type 1 Vpr.
Q77944151Nucleocytoplasmic shuttling by protein nuclear import factors
Q30453773Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides.
Q34245364Nucleocytoplasmic transport enters the atomic age.
Q40309310Phosphorylation of tyrosine 568 controls nuclear export of Nrf2.
Q35208788Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121.
Q24301742Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3
Q53852943Purification of protein A-tagged yeast ran reveals association with a novel karyopherin beta family member, Pdr6p.
Q22009429RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains
Q34574479RANBP17 is localized to the XY body of spermatocytes and interacts with SPEM1 on the manchette of elongating spermatids
Q28611866Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta
Q28205326RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor
Q34279319Redox control of AP-1-like factors in yeast and beyond
Q24554197Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1
Q37235301Regulated transport into the nucleus of herpesviridae DNA replication core proteins
Q34607123Regulation of mRNA export by nutritional status in fission yeast.
Q36039006Role of the RNA recognition motif of the E1B 55 kDa protein in the adenovirus type 5 infectious cycle
Q34340040Roles of cytoskeletal and junctional plaque proteins in nuclear signaling
Q24290893Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting
Q39607440Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation of sphingosine kinase 2 and protein kinase D.
Q44472217Site-specific conjugation of HIV-1 tat peptides to IgG: a potential route to construct radioimmunoconjugates for targeting intracellular and nuclear epitopes in cancer
Q34515859Slipping through the door: HIV entry into the nucleus
Q30478331Spindle formation in Aspergillus is coupled to tubulin movement into the nucleus
Q24291748Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor
Q28474501Structural model of the Rev regulatory protein from equine infectious anemia virus
Q27618407Structure of importin-beta bound to the IBB domain of importin-alpha
Q33785032The 26S proteasome of the fission yeast Schizosaccharomyces pombe
Q44019111The C-terminal extension of the small GTPase Ran is essential for defining the GDP-bound form
Q34611240The Ketel gene encodes a Drosophila homologue of importin-beta
Q34610978The Ketel(D) dominant-negative mutations identify maternal function of the Drosophila importin-beta gene required for cleavage nuclei formation
Q39610897The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals
Q36428044The direction of transport through the nuclear pore can be inverted
Q33566030The importance of being flexible: the case of basic region leucine zipper transcriptional regulators
Q33605916The matrix protein of vesicular stomatitis virus inhibits nucleocytoplasmic transport when it is in the nucleus and associated with nuclear pore complexes
Q34986205The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p).
Q42941687The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability.
Q24542535The nuclear pore complex
Q39647313The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion
Q41963793The sal3(+) gene encodes an importin-beta implicated in the nuclear import of Cdc25 in Schizosaccharomyces pombe.
Q22009980Transportin-SR, a nuclear import receptor for SR proteins
Q35887800Ubc9 interacts with a nuclear localization signal and mediates nuclear localization of the paired-like homeobox protein Vsx-1 independent of SUMO-1 modification
Q33999580Upstream and downstream of ran GTPase
Q22008010When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin
Q27936568Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway
Q27934476Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export
Q48284859cDNA cloning and spatiotemporal expression during avian embryogenesis of hnRNP A1, a regulatory factor in alternative splicing

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