Potential of microRNAs as novel targets in the alleviation of pathological fear

scientific article published on 13 October 2017

Potential of microRNAs as novel targets in the alleviation of pathological fear is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/GBB.12427
P698PubMed publication ID29028150

P50authorNicolas SingewaldQ56872712
P2093author name stringC P Murphy
P2860cites workMeta-analysis of randomized controlled comparisons of psychopharmacological and psychological treatments for anxiety disordersQ58828891
MicroRNAs: target recognition and regulatory functionsQ24609584
Actin in dendritic spines: connecting dynamics to functionQ24611930
An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAPQ24645518
Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorderQ24646835
Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disordersQ27006437
MicroRNAs as biomarkers for CNS diseaseQ27013998
Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring.Q27339409
A blood based 12-miRNA signature of Alzheimer disease patientsQ27499741
MicroRNA-Mediated Rescue of Fear Extinction Memory by miR-144-3p in Extinction-Impaired Mice.Q46188922
Beta1- and beta2-adrenoceptors in basolateral nucleus of amygdala and their roles in consolidation of fear memory in ratsQ46446082
Facilitation of conditioned fear extinction by d-cycloserine is mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase cascades and requires de novo protein synthesis in basolateral nucleus of amygdalaQ46541698
In vivoknockdown of hippocampal miR-132 expression impairs memory acquisition of trace fear conditioningQ46577546
MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusionQ46765437
Deficits in conditioned fear extinction in obsessive-compulsive disorder and neurobiological changes in the fear circuitQ46972465
Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential.Q47851265
Selective inhibition of miR-92 in hippocampal neurons alters contextual fear memoryQ47852385
Consolidating memoriesQ48054344
MicroRNA loss enhances learning and memory in miceQ48174132
7-Chlorokynurenic acid (7-CTKA) produces rapid antidepressant-like effects: through regulating hippocampal microRNA expressions involved in TrkB-ERK/Akt signaling pathways in mice exposed to chronic unpredictable mild stressQ48252785
Extinction of auditory fear conditioning requires MAPK/ERK activation in the basolateral amygdalaQ48457487
MicroRNA-19b associates with Ago2 in the amygdala following chronic stress and regulates the adrenergic receptor beta 1.Q48462834
Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects.Q48819667
Distinct neural signatures for safety and danger in the amygdala and striatum of the mouseQ48917834
MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN.Q54284943
Targeting the modulation of neural circuitry for the treatment of anxiety disordersQ28248283
Fear Extinction as a Model for Translational Neuroscience: Ten Years of ProgressQ28254365
MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to AntidepressantsQ28293486
Individual differences in recovery from traumatic fearQ28389310
A brain-specific microRNA regulates dendritic spine developmentQ29614753
Learning not to fear: neural correlates of learned safety.Q30419964
Towards new approaches to disorders of fear and anxietyQ30437494
Therapeutic Action of Fluoxetine is Associated with a Reduction in Prefrontal Cortical miR-1971 Expression Levels in a Mouse Model of Posttraumatic Stress DisorderQ30452378
Impaired safety signal learning may be a biomarker of PTSDQ30458753
Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fearQ30476116
Amygdala-dependent fear memory consolidation via miR-34a and Notch signalingQ30587469
The learned safety paradigm as a mouse model for neuropsychiatric researchQ33568518
Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10Q33870720
Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons.Q34044305
MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegenerationQ34101214
The pharmacologic treatment of anxiety disorders: a review of progressQ34128423
The majority of microRNAs detectable in serum and saliva is concentrated in exosomesQ34199626
Guidelines for the pharmacological treatment of anxiety disorders, obsessive–compulsive disorder and posttraumatic stress disorder in primary careQ34271431
Neuronal circuits for fear and anxiety.Q34477053
Differential expression of exosomal microRNAs in prefrontal cortices of schizophrenia and bipolar disorder patientsQ34575008
Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in miceQ35097508
Analysis of microRNA turnover in mammalian cells following Dicer1 ablation.Q35120813
The biological functions of miRNAs: lessons from in vivo studiesQ35132364
Rescue of impaired fear extinction and normalization of cortico-amygdala circuit dysfunction in a genetic mouse model by dietary zinc restrictionQ35146447
Safety Signals Mitigate the Consequences of Uncontrollable Stress Via a Circuit Involving the Sensory Insular Cortex and Bed Nucleus of the Stria TerminalisQ35174566
Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAsQ35189998
microRNA-34c is a novel target to treat dementiasQ35422390
Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanismQ35439618
miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement.Q35487610
Circulating microRNA-144-5p is associated with depressive disordersQ35871861
Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes.Q35892774
Rationally Designed MicroRNA-Based Genetic Classifiers Target Specific Neurons in the BrainQ35990704
miRNA-132: a dynamic regulator of cognitive capacityQ36428643
MicroRNAs in neuronal function and dysfunctionQ36589809
Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neuronsQ36590613
Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.Q36598372
GABAergic mechanisms regulated by miR-33 encode state-dependent fearQ36936672
Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrainQ37013773
Implications of memory modulation for post-traumatic stress and fear disordersQ37118033
Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivoQ37218797
Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinctionQ37414015
miR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depressionQ37633174
Newer insights into the role of miRNA a tiny genetic tool in psychiatric disorders: focus on post-traumatic stress disorder.Q37648299
Neuronal circuits of fear extinctionQ37729302
Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United StatesQ37733842
MicroRNA regulation of neural plasticity and memoryQ37869602
The size and burden of mental disorders and other disorders of the brain in Europe 2010.Q37928182
Fear relief—toward a new conceptual frame work and what endocannabinoids gotta do with itQ37968824
MicroRNAs Shape the Neuronal LandscapeQ38033846
MicroRNA turnover: when, how, and why.Q38037875
Micro-Managing the Circadian Clock: The Role of microRNAs in Biological TimekeepingQ38059069
Neuroepigenetics of memory formation and impairment: the role of microRNAs.Q38184259
MicroRNA-132, -134, and -138: a microRNA troika rules in neuronal dendritesQ38227729
Effects of perinatal mental disorders on the fetus and childQ38278938
Thinking small: towards microRNA-based therapeutics for anxiety disordersQ38310488
Determining the role of microRNAs in psychiatric disordersQ38384194
miRNAs and other non-coding RNAs in posttraumatic stress disorder: A systematic review of clinical and animal studiesQ38431787
MicroRNA-182 regulates amygdala-dependent memory formationQ38455718
Epigenetic germline inheritance in mammals: Looking to the past to understand the futureQ38646209
The role of microRNAs in the therapeutic action of D-cycloserine in a post-traumatic stress disorder animal model: an exploratory study.Q38748692
All Roads Lead to the miRNome: miRNAs Have a Central Role in the Molecular Pathophysiology of Psychiatric Disorders.Q39004820
MicroRNA-144 is a circulating effector of remote ischemic preconditioningQ39154143
miRNAs in synapse development and synaptic plasticityQ39196300
MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activityQ39266200
Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders.Q39312328
The brain-specific microRNA miR-128b regulates the formation of fear-extinction memoryQ39490355
miR-144/451 Promote Cell Proliferation via Targeting PTEN/AKT Pathway in Insulinomas.Q41005611
Systemic delivery of tyrosine-mutant AAV vectors results in robust transduction of neurons in adult miceQ41471833
Switching on and off fear by distinct neuronal circuits.Q42438392
Conditioned reflexes: An investigation of the physiological activity of the cerebral cortexQ42759566
Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAsQ43061388
The economic cost of brain disorders in EuropeQ44814293
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
P577publication date2017-10-13
P1433published inGenes, Brain and BehaviorQ112067
P1476titlePotential of microRNAs as novel targets in the alleviation of pathological fear

Reverse relations

cites work (P2860)
Q91947760A miR-567-PIK3AP1-PI3K/AKT-c-Myc feedback loop regulates tumour growth and chemoresistance in gastric cancer
Q58091557Rodent models of impaired fear extinction

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