N-terminal domains in the NR2 subunit control desensitization of NMDA receptors

scientific article published in February 1998

N-terminal domains in the NR2 subunit control desensitization of NMDA receptors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0896-6273(00)80459-6
P698PubMed publication ID9491992

P2093author name stringHeinemann SF
Westbrook GL
Vissel B
Krupp JJ
P2860cites workThe crystal structure of glutamine-binding protein from Escherichia coliQ27733454
Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNSQ28264941
Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunitQ28278075
Developmental and regional expression in the rat brain and functional properties of four NMDA receptorsQ28570615
Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteinsQ28581418
Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extensionQ29547330
Cloned glutamate receptorsQ29619950
Three-dimensional models of non-NMDA glutamate receptorsQ30177008
Desensitization of N-methyl-D-aspartate receptors: a problem of interpretation.Q33835444
Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gatingQ34047145
Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiineQ34247969
Structural conservation of ion conduction pathways in K channels and glutamate receptorsQ34271863
N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1.Q34327802
Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunitQ34422886
Trapping of organic blockers by closing of voltage-dependent K+ channels: evidence for a trap door mechanism of activation gating.Q36411850
Molecular dissection of the agonist binding site of an AMPA receptor.Q38287925
Unraveling the modular design of glutamate-gated ion channelsQ40401475
N-methyl-D-aspartic acid receptor structure and functionQ40674725
The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteinsQ41074853
Identification of amino acid residues that control functional behavior in GluR5 and GluR6 kainate receptorsQ41082010
AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate.Q41157007
The impact of receptor desensitization on fast synaptic transmissionQ41367149
Calcium-dependent inactivation of heteromeric NMDA receptor-channels expressed in human embryonic kidney cells.Q41377770
Mutations in the channel domain alter desensitization of a neuronal nicotinic receptorQ42617071
Allosteric activation and tuning of ligand efficacy in cyclic-nucleotide-gated channelsQ42654293
Zinc potentiates agonist-lnduced currents at certain splice variants of the NMDA receptorQ45975434
Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteinsQ46739659
Interactions between the glycine and glutamate binding sites of the NMDA receptor.Q48328504
Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calciumQ48344157
Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptorsQ48944206
Differential contribution of the NR1- and NR2A-subunits to the selectivity filter of recombinant NMDA receptor channelsQ49016668
Structural determinants of allosteric regulation in alternatively spliced AMPA receptorsQ49058657
Beta-adrenergic regulation of synaptic NMDA receptors by cAMP-dependent protein kinaseQ49133448
Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines.Q50760890
A venus flytrap mechanism for activation and desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors.Q50761820
Interdomain interactions underlying activation of cyclic nucleotide-gated channels.Q52527323
Synaptic NMDA receptor channels have a low open probability.Q54012474
Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine.Q54112154
Determination of NMDA NR1 subunit copy number in recombinant NMDA receptorsQ57908073
Glycine-insensitive desensitization of NMDA responses in cultured mouse embryonic neuronsQ68461323
Glutamate receptor desensitization and its role in synaptic transmissionQ69378713
Identification of the amino acid subsets accounting for the ligand binding specificity of a glutamate receptorQ71821463
Synaptic desensitization of NMDA receptors by calcineurinQ72600088
Regulation of glycine-insensitive desensitization of the NMDA receptor in outside-out patchesQ72865060
Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptorsQ74023744
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectdesensitizationQ2700499
P304page(s)317-327
P577publication date1998-02-01
P1433published inNeuronQ3338676
P1476titleN-terminal domains in the NR2 subunit control desensitization of NMDA receptors
P478volume20

Reverse relations

cites work (P2860)
Q4037348120-oxo-5beta-pregnan-3alpha-yl sulfate is a use-dependent NMDA receptor inhibitor.
Q42764109A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors.
Q40055046A domain linking the AMPA receptor agonist binding site to the ion pore controls gating and causes lurcher properties when mutated.
Q40996183A point mutation in the glutamate binding site blocks desensitization of AMPA receptors
Q40692616A site in the fourth membrane-associated domain of the N-methyl-D-aspartate receptor regulates desensitization and ion channel gating
Q40803792A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux
Q40782999Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A.
Q40372985Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors
Q77694440Allosteric receptors after 30 years
Q28210064Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain
Q42119843Amino-terminal ligands prolong NMDA Receptor-mediated EPSCs
Q73567660An orphan glutamate channel points the way to the gates
Q40635224Arginine 222 in the pre-transmembrane domain 1 of 5-HT3A receptors links agonist binding to channel gating
Q34126455Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia
Q43088571Asynchronous movements prior to pore opening in NMDA receptors
Q37626413CGX-1007 prevents excitotoxic cell death via actions at multiple types of NMDA receptors
Q40734907Calcineurin acts via the C-terminus of NR2A to modulate desensitization of NMDA receptors
Q28281484Calmodulin mediates calcium-dependent inactivation of N-methyl-D-aspartate receptors
Q35850964Characterization of the gating conformational changes in the felbamate binding site in NMDA channels
Q42580097Cloning and Phylogenetic Analysis of NMDA Receptor Subunits NR1, NR2A and NR2B in Xenopus laevis Tadpoles
Q28363686Desensitization of NMDA receptor channels is modulated by glutamate agonists
Q35013120Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons
Q44681131Developmental decrease in NMDA receptor desensitization associated with shift to synapse and interaction with postsynaptic density-95.
Q43774334Developmental regulation of N-methyl-D-aspartate- and kainate-type glutamate receptor expression in the rat spinal cord
Q91739964Distinct roles of GRIN2A and GRIN2B variants in neurological conditions
Q44944785Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors
Q40778163Dominance of the lurcher mutation in heteromeric kainate and AMPA receptor channels
Q40609104Dynorphin A inhibits NMDA receptors through a pH-dependent mechanism
Q53913902Enhancement of NMDA receptor-mediated currents by light in rat neurones in vitro.
Q40778511Ethanol inhibition of N-methyl-D-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue
Q40834702Ethanol sensitivity of recombinant human N-methyl-D-aspartate receptors
Q36476996Expression and characterization of soluble amino-terminal domain of NR2B subunit of N-methyl-D-aspartate receptor.
Q48892598Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors
Q28566552Functional analysis of the rat N-methyl-D-aspartate receptor 2A promoter: multiple transcription starts points, positive regulation by Sp factors, and translational regulation
Q28290774Glutamate receptor ion channels: structure, regulation, and function
Q36990537Glutamate receptor plasticity and activity-regulated cytoskeletal associated protein regulation in the phrenic motor nucleus may mediate spontaneous recovery of the hemidiaphragm following chronic cervical spinal cord injury
Q41767341Glutamate receptor subunit and calmodulin kinase II expression, with and without T maze training, in the rat hippocampus following bilateral vestibular deafferentation.
Q51381870Glutamate-mediated neuroprotection against N-methyl-D-aspartate toxicity: a role for metabotropic glutamate receptors.
Q33846573How well can molecular modelling predict the crystal structure: the case of the ligand-binding domain of glutamate receptors
Q39227836Identification of an atypical calcium-dependent calmodulin binding site on the C-terminal domain of GluN2A
Q44540735Induction of dendritic spines by an extracellular domain of AMPA receptor subunit GluR2.
Q28296865Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+-dependent inactivation of NMDA receptors
Q40761115Intersubunit cooperativity in the NMDA receptor
Q34471132Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics
Q35925883Ionotropic glutamate receptor recognition and activation
Q33695790Ionotropic glutamate receptors
Q40699149Kainate-binding proteins are rendered functional ion channels upon transplantation of two short pore-flanking domains from a kainate receptor
Q42056331Large-scale expression and thermodynamic characterization of a glutamate receptor agonist-binding domain
Q36076557MK-801 upregulates NR2A protein levels and induces functional recovery of the ipsilateral hemidiaphragm following acute C2 hemisection in adult rats
Q44067007Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors.
Q35415834Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators
Q47255869Memantine and Ketamine Differentially Alter NMDA Receptor Desensitization.
Q39450031Modulating synaptic NMDA receptors
Q28776368Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptors
Q43694844Molecular dynamics simulations of the conformational changes of the glutamate receptor ligand-binding core in the presence of glutamate and kainate.
Q41737191Molecular neurobiology and genetics: investigation of neural function and dysfunction
Q50719477Molecular organization of a zinc binding n-terminal modulatory domain in a NMDA receptor subunit.
Q35911379Molecular pharmacology of human NMDA receptors
Q43846767Molecular rearrangements of the extracellular vestibule in NMDAR channels during gating
Q40892584Mutation of a glutamate receptor motif reveals its role in gating and delta2 receptor channel properties.
Q48029905NMDA Receptors in the Central Nervous System
Q90715019NMDA receptor channel gating control by the pre-M1 helix
Q48921111NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines
Q36958209On the hypes and falls in neuroprotection: targeting the NMDA receptor
Q42615276Probing of NMDA channels with fast blockers
Q40328621Protein kinase C enhances glycine-insensitive desensitization of NMDA receptors independently of previously identified protein kinase C sites
Q33691516Recent excitement in the ionotropic glutamate receptor field
Q46941543Regulated expression of N-methyl-D-aspartate receptors and associated proteins in teleost electrosensory system and telencephalon
Q48193737Resident Calmodulin Primes NMDA Receptors for Ca2+-Dependent Inactivation
Q28587572Retina-driven dephosphorylation of the NR2A subunit correlates with faster NMDA receptor kinetics at developing retinocollicular synapses
Q33730425Shaping excitation at glutamatergic synapses
Q35144764Signaling molecules and receptor transduction cascades that regulate NMDA receptor-mediated synaptic transmission
Q35514668Specific sites within the ligand-binding domain and ion channel linkers modulate NMDA receptor gating
Q34179425Staggering of subunits in NMDAR channels.
Q31839971Structural determinants of fast desensitization and desensitization-deactivation coupling in GABAa receptors.
Q90425146Structure, function, and allosteric modulation of NMDA receptors
Q40937326Subtype-dependence of NMDA receptor channel open probability.
Q33721650Subunit- and site-specific pharmacology of the NMDA receptor channel
Q40471504Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles.
Q52571510Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit.
Q40955590The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro
Q28579343The structure and function of glutamate receptor ion channels
Q24290661Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains
Q30842128Use of proteoliposomes to generate phage antibodies against native AMPA receptor
Q34509219Zinc reverses glycine-dependent inactivation of NMDARs in cultured rat hippocampal neurons

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