Mutations in the elongation factor 2 gene which confer resistance to diphtheria toxin and Pseudomonas exotoxin A. Genetic and biochemical analyses

scientific article

Mutations in the elongation factor 2 gene which confer resistance to diphtheria toxin and Pseudomonas exotoxin A. Genetic and biochemical analyses is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.270.39.23218
P8608Fatcat IDrelease_xzm2ixfgwvbwped6gwwcacs5hi
P698PubMed publication ID7559470

P2093author name stringMoehring JM
Moehring TJ
Foley BT
P2860cites workTowards a natural system of organisms: proposal for the domains Archaea, Bacteria, and EucaryaQ22066209
Cellular ADP-ribosyltransferase with the same mechanism of action as diphtheria toxin and Pseudomonas toxin AQ24596505
Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferaseQ35340408
Amino acid sequence of mammalian elongation factor 2 deduced from the cDNA sequence: homology with GTP-binding proteinsQ35615941
Posttranslational modification of elongation factor 2 in diphtheria-toxin-resistant mutants of CHO-K1 cellsQ36356607
Homology dependence of targeted recombination at the Chinese hamster APRT locusQ36667309
In vitro biosynthesis of diphthamide, studied with mutant Chinese hamster ovary cells resistant to diphtheria toxinQ36943369
Diphtheria toxin-resistant mutants of Saccharomyces cerevisiaeQ36952490
Identification of calmodulin-dependent protein kinase III and its major Mr 100,000 substrate in mammalian tissuesQ37537893
Discovery, resolution, purification, and function of elongation factorsQ37907182
In vivo selection of conditional-lethal mutations in the gene encoding elongation factor G of Escherichia coliQ39930008
An inexpensive and simple method for DNA purifications on silica particlesQ40405604
Codominant translational mutants of Chinese hamster ovary cells selected with diphtheria toxinQ40617110
Characterization of diphtheria-toxin-resistant mutants lacking receptor function or containing nonribosylatable elongation factor 2.Q41483566
A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirusQ48378635
A mutation in codon 717 of the CHO-K1 elongation factor 2 gene prevents the first step in the biosynthesis of diphthamide.Q54271591
Characterization of the diphtheria toxin-resistance system in Chinese hamster ovary cellsQ66950333
The histidine residue of codon 715 is essential for function of elongation factor 2Q69587060
ADP-ribosylatable content of elongation factor-2 changes during cell cycle of normal and cancerous human cellsQ69973797
GenBankQ72834365
P433issue39
P407language of work or nameEnglishQ1860
P304page(s)23218-23225
P577publication date1995-09-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleMutations in the elongation factor 2 gene which confer resistance to diphtheria toxin and Pseudomonas exotoxin A. Genetic and biochemical analyses
P478volume270

Reverse relations

described by source (P1343)
Q127380433CH-K1W1.P17
Q127380435CH-P1R2.D11
Q127380437CH-P1R2.D20
Q127380438CH-P1R2.D8
Q127380440CH-R1.41
Q127380445CH-RE1.22
Q127380446CH-RE1.22c
Q127380450CH-RE1.32
Q127380455CH-RE5b.2
Q127380456CH-RPE.10
Q127380458CH-RPE.11a

cites work (P2860)
Q36450314A conserved eEF2 coding variant in SCA26 leads to loss of translational fidelity and increased susceptibility to proteostatic insult
Q35230663A guide to taming a toxin--recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer
Q37112692ADP-ribosylation of translation elongation factor 2 by diphtheria toxin in yeast inhibits translation and cell separation
Q33829020Biology and molecular epidemiology of diphtheria toxin and the tox gene
Q33530068Characterization of a Chinese hamster ovary cell mutant having a mutation in elongation factor-2.
Q42646387Cloning and expression of translation elongation factor 2 (EF-2) in zebrafish
Q40260739Construction and use of retroviral vectors encoding the toxic gene barnase.
Q45021734Crystal structure of ADP-ribosylated ribosomal translocase from Saccharomyces cerevisiae
Q36187473Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development
Q64949366Diphtheria Toxin A-Resistant Cell Lines Enable Robust Production and Evaluation of DTA-Encoding Lentiviruses.
Q27643165Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation
Q34444939Engineering toxin-resistant therapeutic stem cells to treat brain tumors
Q38853906Evolution of the archaeal and mammalian information processing systems: towards an archaeal model for human disease
Q36067022Form follows function: structure of an elongation factor G-ribosome complex
Q33210643Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 2.
Q35211777Interaction of pseudomonas aeruginosa with epithelial cells: identification of differentially regulated genes by expression microarray analysis of human cDNAs
Q44441669Morphological and immunological evidence of a unique selective production and endoplasmic reticular accumulation of interleukin-1α in rat peritoneal macrophages induced by Pseudomonas aeruginosa exotoxin A
Q89581152PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis
Q39684059PG13 packaging cells produce recombinant retroviruses carrying a diphtheria toxin mutant which kills cancer cells
Q27323196Pseudomonas aeruginosa exotoxin T induces potent cytotoxicity against a variety of murine and human cancer cell lines.
Q27937056Stm1p alters the ribosome association of eukaryotic elongation factor 3 and affects translation elongation
Q24528153Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa
Q27936235Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 A resolution
Q37882043Unique modifications of translation elongation factors
Q52651261Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy.

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