An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition.

scientific article published on 18 May 2017

An Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/ACS.BIOCHEM.6B01182
P932PMC publication ID5956896
P698PubMed publication ID28516764

P50authorScott E BoykenQ57306990
Amy H. AndreottiQ88093154
P2093author name stringD Bruce Fulton
Raji E Joseph
Sujan Devkota
P2860cites workA crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchangeQ24292431
Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemiaQ24532248
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Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase InhibitionQ27664839
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Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activityQ28249985
Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinasesQ28507413
Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphateQ30009224
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Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemiaQ30195143
Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2.Q33215188
Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.Q33874259
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Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A productionQ34724853
Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancersQ36436853
Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinaseQ36590074
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Bacterial expression and purification of interleukin-2 tyrosine kinase: single step separation of the chaperonin impurityQ36969369
Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferationQ37170806
The Src, Syk, and Tec family kinases: distinct types of molecular switchesQ37703668
Conditional peripheral membrane proteins: facing up to limited specificityQ37970875
Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in LymphocytesQ38395493
Protein Regulation in Signal TransductionQ38851156
Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec.Q39970262
PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes.Q51154659
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P433issue23
P407language of work or nameEnglishQ1860
P304page(s)2938-2949
P577publication date2017-05-25
P1433published inBiochemistryQ764876
P1476titleAn Autoinhibitory Role for the Pleckstrin Homology Domain of Interleukin-2-Inducible Tyrosine Kinase and Its Interplay with Canonical Phospholipid Recognition
P478volume56

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cites work (P2860)
Q92906541A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent Functions
Q90117413HIV-1 Nef dimers short-circuit immune receptor signaling by activating Tec-family kinases at the host cell membrane
Q90573543Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases
Q57752422The Src module: an ancient scaffold in the evolution of cytoplasmic tyrosine kinases