p38 differentially regulates ERK, p21, and mitogenic signalling in two pancreatic carcinoma cell lines

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p38 differentially regulates ERK, p21, and mitogenic signalling in two pancreatic carcinoma cell lines is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12079-017-0444-0
P932PMC publication ID6235781
P698PubMed publication ID29380233

P50authorMonica AasrumQ95966225
P2093author name stringThoralf Christoffersen
G Hege Thoresen
Ingvild J Brusevold
P2860cites workMigration induced by epidermal and hepatocyte growth factors in oral squamous carcinoma cells in vitro: role of MEK/ERK, p38 and PI‐3 kinase/AktQ39380720
SB203580, a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytes.Q39957327
Up-regulation of p21CIP1 expression mediated by ERK-dependent and -independent pathways contributes to hepatocyte growth factor-induced inhibition of HepG2 hepatoma cell proliferationQ40051472
Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells.Q40202337
Increased stability of P21(WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamateQ40244502
MEK/ERK-mediated proliferation is negatively regulated by P38 map kinase in the human pancreatic cancer cell line, PANC-1.Q40799925
High-intensity p38 kinase activity is critical for p21(cip1) induction and the antiproliferative function of G(i) protein-coupled receptorsQ40812213
The Raf-1/MEK/ERK pathway regulates the expression of the p21(Cip1/Waf1) gene in chondrocytesQ40924273
Cooperation of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways during granulocyte colony-stimulating factor-induced hemopoietic cell proliferationQ40975219
Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.Q41173912
Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytesQ42457194
Hepatocyte growth factor stimulates cell growth and enhances the expression of transforming growth factor alpha mRNA in AsPC-1 human pancreatic cancer cellsQ42476349
Hepatocyte growth factor/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1.Q43890944
The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylationQ44023068
Multiple mitogenic pathways in pancreatic cancer cells are blocked by a truncated epidermal growth factor receptorQ44164603
Biological and immunological properties of human hepatocyte growth factor from plasma of patients with fulminant hepatic failureQ44322676
Role of ERK, p38 and PI3-kinase in EGF receptor-mediated mitogenic signalling in cultured rat hepatocytes: requirement for sustained ERK activationQ44522579
p38 MAP kinase signaling is necessary for rat chondrosarcoma cell proliferationQ47677865
Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.Q50749097
HGF-induced DNA synthesis in hepatocytes is suppressed by p38.Q53657877
Genetics and Biology of Pancreatic Ductal AdenocarcinomaQ54255820
ERK1/2 and p38 pathways are required for P2Y receptor-mediated prostate cancer invasion.Q54704420
The involvement of the docking protein Gab1 in mitogenic signalling induced by EGF and HGF in rat hepatocytes.Q54761450
Stimulation of hepatocyte DNA synthesis by prostaglandin E2 and prostaglandin F2 alpha: additivity with the effect of norepinephrine, and synergism with epidermal growth factorQ72317104
Comparative effects of hepatocyte growth factor and epidermal growth factor on motility, morphology, mitogenesis, and signal transduction of primary rat hepatocytesQ72809767
Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cellsQ74366561
One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascadeQ77955135
The p38 transduction pathway in prostatic neoplasiaQ82045634
Pancreatic cancerQ87198210
The selectivity of protein kinase inhibitors: a further updateQ24654622
Examination of the expanding pathways for the regulation of p21 expression and activityQ27692024
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activationQ28131755
A synthetic inhibitor of the mitogen-activated protein kinase cascadeQ28367955
p21 in cancer: intricate networks and multiple activitiesQ30436015
Mist1 regulates pancreatic acinar cell proliferation through p21 CIP1/WAF1Q33783645
Phenotype and genotype of pancreatic cancer cell linesQ33814471
The p38 signal transduction pathway: activation and functionQ33838955
p38 MAP kinases: beyond the stress responseQ33934138
Mechanisms and functions of p38 MAPK signalling.Q34125736
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytesQ34415888
Cell cycle regulation by p38 MAP kinasesQ34454899
ERK implication in cell cycle regulationQ34594561
Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescenceQ35174677
p38 MAP kinase's emerging role as a tumor suppressorQ35941622
Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issuesQ36101745
MAPK signal specificity: the right place at the right timeQ36444123
Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancerQ36547939
Functional p38 MAPK identified by biomarker profiling of pancreatic cancer restrains growth through JNK inhibition and correlates with improved survivalQ36899872
p38alpha: a suppressor of cell proliferation and tumorigenesisQ36980265
Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survivalQ37015135
Non-classical p38 map kinase functions: cell cycle checkpoints and survivalQ37374255
Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control studyQ37485098
Signal integration by JNK and p38 MAPK pathways in cancer developmentQ37560607
p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cellsQ38519488
p21: A Two-Faced Genome Guardian.Q38747952
Lysophosphatidic acid induces both EGFR-dependent and EGFR-independent effects on DNA synthesis and migration in pancreatic and colorectal carcinoma cellsQ38834081
P433issue4
P921main subjectpancreatic carcinomaQ18556536
P304page(s)699-707
P577publication date2018-01-29
P1433published inJournal of Cell Communication and SignalingQ26841964
P1476titlep38 differentially regulates ERK, p21, and mitogenic signalling in two pancreatic carcinoma cell lines
P478volume12

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