Givinostat reduces adverse cardiac remodeling through regulating fibroblasts activation.

scientific article

Givinostat reduces adverse cardiac remodeling through regulating fibroblasts activation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41419-017-0174-5
P932PMC publication ID5833837
P698PubMed publication ID29371598

P50authorGiuseppe MaranoQ54230596
Denisa BaciQ55754927
Elena De FalcoQ56930260
Luca MadaroQ83508004
Marika MilanQ86392715
P2093author name stringRoberto Rizzi
Pier Lorenzo Puri
Giacomo Frati
Claudia Bearzi
Sonia Maccari
Tonino Stati
Valentina Pace
Fabio Maiullari
Maila Chirivì
Silvia Maiullari
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Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagyQ24603793
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Cardiosphere conditioned media influence the plasticity of human mediastinal adipose tissue-derived mesenchymal stem cells.Q51659834
Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritisQ61633704
Transforming growth factor beta 1 induces apoptotic cell death in cultured human umbilical vein endothelial cells with down-regulated expression of bcl-2Q72269420
Good and bad sides of TGFβ-signaling in myocardial infarctionQ26863465
Molecular mechanisms of epithelial-mesenchymal transitionQ27013743
Post-natal cardiomyocytes can generate iPS cells with an enhanced capacity toward cardiomyogenic re-differentationQ30515858
PlGF-MMP9-engineered iPS cells supported on a PEG-fibrinogen hydrogel scaffold possess an enhanced capacity to repair damaged myocardiumQ30573513
Genetic lineage tracing defines myofibroblast origin and function in the injured heartQ33908363
The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivoQ34504770
New generation small-molecule inhibitors in myeloproliferative neoplasms.Q34634950
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The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitroQ35017018
Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in miceQ35135731
Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tractQ35576426
Anti-Fibrotic Effects of Class I HDAC Inhibitor, Mocetinostat Is Associated with IL-6/Stat3 Signaling in Ischemic Heart FailureQ35723859
Histone deacetylases and cardiovascular cell lineage commitmentQ35774293
Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesisQ35847709
Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubulesQ35849001
Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophagesQ36342694
ITF2357 transactivates Id3 and regulate TGFβ/BMP7 signaling pathways to attenuate corneal fibrosisQ36569602
Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemiaQ37045533
HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responsesQ37073624
Histone deacetylase inhibitors as therapeutic agents for acute central nervous system injuriesQ37832963
Therapeutic potential for HDAC inhibitors in the heartQ37937667
Oxidative stress and mitochondrial dysfunction in aluminium neurotoxicity and its amelioration: a review.Q38190319
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Histone deacetylase inhibitors: a potential epigenetic treatment for Duchenne muscular dystrophy.Q38272315
Role of innate and adaptive immune mechanisms in cardiac injury and repairQ38329556
Knockdown of SOX9 Inhibits the Proliferation, Invasion, and EMT in Thyroid Cancer CellsQ38712987
The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis.Q38875774
Predictors of Ischemic Stroke in Rheumatic Heart DiseaseQ38959776
Metformin mediated reversal of epithelial to mesenchymal transition is triggered by epigenetic changes in E-cadherin promoterQ39480588
Transcriptional activation of cartilage oligomeric matrix protein by Sox9, Sox5, and Sox6 transcription factors and CBP/p300 coactivatorsQ40136077
The potential of GMP-compliant platelet lysate to induce a permissive state for cardiovascular transdifferentiation in human mediastinal adipose tissue-derived mesenchymal stem cells.Q41901872
Up-regulation of alpha-smooth muscle actin in cardiomyocytes from non-hypertrophic and non-failing transgenic mouse hearts expressing N-terminal truncated cardiac troponin I.Q42846330
Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse heartsQ42946844
Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitorsQ44449807
BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injuryQ44479221
BMP-7 blocks the effects of TGF-β-induced EMT in cholangiocarcinomaQ45083311
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue2
P304page(s)108
P577publication date2018-01-25
P1433published inCell Death and DiseaseQ2197222
P1476titleGivinostat reduces adverse cardiac remodeling through regulating fibroblasts activation
P478volume9

Reverse relations

cites work (P2860)
Q92323965Endothelial to Mesenchymal Transition: Role in Physiology and in the Pathogenesis of Human Diseases
Q92465956Epigenetics in Cardiac Hypertrophy and Heart Failure
Q92324516HDAC inhibitors as antifibrotic drugs in cardiac and pulmonary fibrosis
Q90272942Neuroprotective mechanism of TMP269, a selective class IIA histone deacetylase inhibitor, after cerebral ischemia/reperfusion injury
Q64063293Regulation of Chemokines and Cytokines by Histone Deacetylases and an Update on Histone Decetylase Inhibitors in Human Diseases
Q98224256The Roles of Noncardiomyocytes in Cardiac Remodeling

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