The structure of serum resistance-associated protein and its implications for human African trypanosomiasis

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The structure of serum resistance-associated protein and its implications for human African trypanosomiasis is …
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scholarly articleQ13442814

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P356DOI10.1038/S41564-017-0085-3
P2888exact matchhttps://scigraph.springernature.com/pub.10.1038/s41564-017-0085-3
P698PubMed publication ID29358741

P50authorCarol V. RobinsonQ56190
Matthew K. HigginsQ43240638
Mark CarringtonQ56544464
Sebastian ZollQ58833134
P2093author name stringShahid Mehmood
Jonathan Schneider
Harriet Lane-Serff
P2860cites workC-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesienseQ21559412
Apolipoprotein L-I is the trypanosome lytic factor of human serumQ24297009
Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranesQ24307804
Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunityQ24628085
PHENIX: a comprehensive Python-based system for macromolecular structure solutionQ24654617
Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assemblyQ27316710
Structural Characterization and Epitope Mapping of the Glutamic Acid/Alanine-rich Protein from Trypanosoma congolense: DEFINING ASSEMBLY ON THE PARASITE CELL SURFACEQ27667447
Structural basis for trypanosomal haem acquisition and susceptibility to the host innate immune systemQ27696195
XDSQ27860472
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Overview of the CCP4 suite and current developmentsQ27860782
Phasercrystallographic softwareQ27860930
Refinement of macromolecular structures by the maximum-likelihood methodQ27861011
Features and development of CootQ27861079
Lysine methylation as a routine rescue strategy for protein crystallizationQ29619069
Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1Q30663833
Evolution of the primate trypanolytic factor APOL1Q33665446
A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesienseQ34484958
Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: relevance to trypanosome lysisQ35157040
Endosomal localization of the serum resistance-associated protein in African trypanosomes confers human infectivityQ35191822
Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptorQ35248305
Endocytosis of a cytotoxic human high density lipoprotein results in disruption of acidic intracellular vesicles and subsequent killing of African trypanosomes.Q36234397
Trypanosome Lytic Factor-1 Initiates Oxidation-stimulated Osmotic Lysis of Trypanosoma brucei bruceiQ36548456
Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse modelQ36851932
Accurate assessment of mass, models and resolution by small-angle scatteringQ37021738
Identification of the trypanocidal factor in normal human serum: high density lipoproteinQ37591101
Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein familiesQ38180023
The molecular arms race between African trypanosomes and humansQ38224214
Localization of serum resistance-associated protein in Trypanosoma brucei rhodesiense and transgenic Trypanosoma brucei brucei.Q38894984
DAMMIF, a program for rapid ab-initio shape determination in small-angle scatteringQ39388340
Serum resistance-associated protein blocks lysosomal targeting of trypanosome lytic factor in Trypanosoma bruceiQ41863115
Two variant surface glycoproteins of Trypanosoma brucei of different sequence classes have similar 6 A resolution X-ray structuresQ46209223
Creation of recombinant antigen-binding molecules derived from hybridomas secreting specific antibodies.Q46474062
Trypanosome lytic factor, a subclass of high-density lipoprotein, forms cation-selective pores in membranesQ46565343
The origin of the serum resistance associated (SRA) gene and a model of the structure of the SRA polypeptide from Trypanosoma brucei rhodesiense.Q48556887
Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC.Q51066780
PRIMUS: a Windows PC-based system for small-angle scattering data analysisQ57091059
Trypanosoma brucei: biochemical and morphological studies of cytotoxicity caused by normal human serumQ71426931
High-density-lipoprotein-independent killing of Trypanosoma brucei by human serumQ71965406
Universal PCR amplification of mouse immunoglobulin gene variable regions: the design of degenerate primers and an assessment of the effect of DNA polymerase 3' to 5' exonuclease activityQ73387754
P921main subjectprotein structureQ735188
African trypanosomiasisQ203133
trypanosomiasisQ2443552
P577publication date2018-01-22
P1433published inNature MicrobiologyQ23022567
P1476titleThe structure of serum resistance-associated protein and its implications for human African trypanosomiasis

Reverse relations

Q89051422APOL1: The Balance Imposed by Infection, Selection, and Kidney Diseasecites workP2860

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