The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis

scientific article published in February 1999

The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1006/EXNR.1998.7002
P8608Fatcat IDrelease_pljrwhsxgzhzhbpeev722mc72u
P698PubMed publication ID10072306

P50authorMark MattsonQ6768760
P2093author name stringLuo H
Yu Z
Fu W
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
apoptotic processQ14599311
excitotoxicityQ901117
P304page(s)302-314
P577publication date1999-02-01
P1433published inExperimental NeurologyQ5421127
P1476titleThe endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis
P478volume155

Reverse relations

cites work (P2860)
Q40578520A cellular UDP-glucose deficiency causes overexpression of glucose/oxygen-regulated proteins independent of the endoplasmic reticulum stress elements.
Q28259344A molecular chaperone inducer protects neurons from ER stress
Q35894179A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis
Q28572264AGEs induce cell death via oxidative and endoplasmic reticulum stresses in both human SH-SY5Y neuroblastoma cells and rat cortical neurons
Q42441252Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder
Q48333131Activation of caspase-12 by endoplasmic reticulum stress induced by transient middle cerebral artery occlusion in mice.
Q44435156Activation of endoplasmic reticulum stress signaling pathway is associated with neuronal degeneration in MoMuLV-ts1-induced spongiform encephalomyelopathy
Q44163334Activation of stress signaling molecules in bat brain during arousal from hibernation
Q44084444Acute and chronic alterations in calcium homeostasis in 3-nitropropionic acid-treated human NT2-N neurons.
Q39026385Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance
Q33750504Age and energy intake interact to modify cell stress pathways and stroke outcome
Q35771777Age-related thermal response: the cellular resilience of juveniles
Q46606844Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins
Q34990005Alterations in energy metabolism, neuroprotection and visual signal transduction in the retina of Parkinsonian, MPTP-treated monkeys
Q38283033Aminolaevulinic acid-induced photodynamic therapy: cellular responses to glucose starvation
Q33594792Analysis of spatial and temporal protein expression in the cerebral cortex after ischemia-reperfusion injury
Q60937807Apoptosis Induction via ATM Phosphorylation, Cell Cycle Arrest, and ER Stress by Goniothalamin and Chemodrugs Combined Effects on Breast Cancer-Derived MDA-MB-231 Cells
Q33891347Apoptotic and anti-apoptotic synaptic signaling mechanisms
Q44374041Attenuation of N-methyl-D-aspartate-mediated cytoplasmic vacuolization in primary rat hippocampal neurons by mood stabilizers
Q37598601BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis
Q37367025Bcl-2 family proteins as regulators of oxidative stress
Q42489173Beneficial effects of dietary restriction on cerebral cortical synaptic terminals: preservation of glucose and glutamate transport and mitochondrial function after exposure to amyloid beta-peptide, iron, and 3-nitropropionic acid.
Q89495923Benefits of aged garlic extract on Alzheimer's disease: Possible mechanisms of action
Q34687452Cadmium induces the expression of Grp78, an endoplasmic reticulum molecular chaperone, in LLC-PK1 renal epithelial cells
Q55002430Calbindin-D28k in the Brain Influences the Expression of Cellular Prion Protein.
Q33899480Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders
Q34569825Caloric restriction and intermittent fasting: two potential diets for successful brain aging
Q38557903Calorie restriction and stroke
Q35764325Cell degeneration induced by amyloid-beta peptides: implications for Alzheimer's disease.
Q24654460Cellular interplay between neurons and glia: toward a comprehensive mechanism for excitotoxic neuronal loss in neurodegeneration
Q28384232Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders
Q42827985Changes in BiP (GRP78) levels upon HSV-1 infection are strain dependent
Q30487732Changes in brain gene expression during migration in the white-crowned sparrow
Q34815474Chaperones and aging: role in neurodegeneration and in other civilizational diseases
Q37447674Characterization of the endocannabinoid system in human neuronal cells and proteomic analysis of anandamide-induced apoptosis
Q27490910Classic swine fever virus NS2 protein leads to the induction of cell cycle arrest at S-phase and endoplasmic reticulum stress
Q33394120Classical swine fever virus NS2 protein promotes interleukin-8 expression and inhibits MG132-induced apoptosis
Q28582544Cloning and characterization of a novel GRP78-binding protein in the rat brain
Q73387845Concentration- and cell type-specific effects of calbindin D28k on vulnerability of hippocampal neurons to seizure-induced injury
Q57031032Conotoxin MVIIA improves cell viability and antioxidant system after spinal cord injury in rats
Q35038663Contributions of mitochondrial alterations, resulting from bad genes and a hostile environment, to the pathogenesis of Alzheimer's disease
Q35649891Coupling endoplasmic reticulum stress to the cell death program
Q33636122Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat
Q40793113Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation
Q24293643Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78
Q45242538Damage to the endoplasmic reticulum and activation of apoptotic machinery by oxidative stress in ischemic neurons
Q37054253Defects of mitochondrial electron transport chain in bipolar disorder: implications for mood-stabilizing treatment
Q33911655Depletion of calcium stores in injured sensory neurons: anatomic and functional correlates
Q48087848Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation
Q36453964Differential Proteomic Analysis of Human Placenta-Derived Mesenchymal Stem Cells Cultured on Normal Tissue Culture Surface and Hyaluronan-Coated Surface
Q28581651Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons
Q34509797Dysregulation of cellular calcium homeostasis in Alzheimer's disease: bad genes and bad habits
Q80389833ERp29, a general endoplasmic reticulum marker, is highly expressed throughout the brain
Q48848009Effects of 2-Deoxyglucose on ischemic brain injuries in rats
Q24677404Effects of environmental enrichment on gene expression in the brain
Q35643520Effects of hyperbaric oxygen on glucose-regulated protein 78 and c-Jun N-terminal kinase expression after spinal cord injury in rats
Q64094581Efficacy of systemic temozolomide-activated phage-targeted gene therapy in human glioblastoma
Q35122788Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease
Q35644629Endoplasmic reticulum Ca(2+) homeostasis and neuronal death.
Q44292449Endoplasmic reticulum calcium storage and release in cells expressing misfolded growth hormone
Q35238170Endoplasmic reticulum chaperone GRP78 is involved in autophagy activation induced by ischemic preconditioning in neural cells
Q24298757Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation
Q38067205Endoplasmic reticulum dysfunction in neurological disease
Q33730922Endoplasmic reticulum stress and inflammation in the central nervous system
Q46173130Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells
Q39640157Endoplasmic reticulum stress inducers provide protection against 6-hydroxydopamine-induced cytotoxicity
Q28572076Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain
Q28573492Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol
Q36812724Endoplasmic reticulum stress.
Q39042225Endoplasmic reticulum-mediated unfolded protein response and mitochondrial apoptosis in cancer
Q35196245Endoplasmic reticulum: a primary target in various acute disorders and degenerative diseases of the brain
Q28202177Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative Disorders
Q44097741Expression of 150-kd oxygen-regulated protein in the hippocampus suppresses delayed neuronal cell death
Q28364460Expression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicity
Q56973969Expression pattern of heat shock proteins during acute thermal stress in the Antarctic sea urchin, Sterechinus neumayeri
Q53657401Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart.
Q28576134Facilitatory roles of novel compounds designed from cyclopentenone prostaglandins on neurite outgrowth-promoting activities of nerve growth factor
Q28486232Functional investigation of NCI-H460-inducible myofibroblasts on the chemoresistance to VP-16 with a microfluidic 3D co-culture device
Q36507488GLP-2 Prevents Intestinal Mucosal Atrophy and Improves Tissue Antioxidant Capacity in a Mouse Model of Total Parenteral Nutrition
Q24302321GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis
Q38692967GRP78 at the Centre of the Stage in Cancer and Neuroprotection
Q39029371GRP78 suppresses lipid peroxidation and promotes cellular antioxidant levels in glial cells following hydrogen peroxide exposure.
Q44553319GRP94 (94 kDa glucose-regulated protein) suppresses ischemic neuronal cell death against ischemia/reperfusion injury
Q42768469Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons
Q44394219Geldanamycin induction of grp78 requires activation of reactive oxygen species via ER stress responsive elements in 9L rat brain tumour cells
Q35571922Gender-dimorphic regulation of DJ1 and its interactions with metabolic proteins in streptozotocin-induced diabetic rats
Q34023661Genesis and reversal of the ischemic phenotype in epithelial cells
Q40771293Grape seed proanthocyanidin protects liver against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress
Q35181079HSP70s: From Tumor Transformation to Cancer Therapy.
Q59792122Heme Induces Endoplasmic Reticulum Stress (HIER Stress) in Human Aortic Smooth Muscle Cells
Q24337566Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress
Q36627066Hormetic effects of acute methylmercury exposure on grp78 expression in rat brain cortex
Q39674687Hydrogen peroxide regulates glucose‐regulated protein 78 expression via a cyclooxygenase‐2 dependent mechanism
Q37441346Hyperoxia augments ER-stress-induced cell death independent of BiP loss
Q43785302Hypothermic treatment restores glucose regulated protein 78 (GRP78) expression in ischemic brain
Q38293347Identification of AKT-regulated genes in inducible MERAkt cells
Q55475244Increased expression of endoplasmic reticulum stress proteins following chronic valproate treatment of rat C6 glioma cells.
Q40562309Induction of 78 kD glucose-regulated protein (GRP78) expression and redox-regulated transcription factor activity by lead and mercury in C6 rat glioma cells
Q39390536Induction of ER Stress-Mediated Apoptosis by α-Lipoic Acid in A549 Cell Lines
Q46598667Induction of GRP78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death
Q30494698Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice
Q40015897Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins
Q43473290Inositol-requiring protein 1α signaling pathway is activated in the temporal cortex of patients with mesial temporal lobe epilepsy
Q35820531Intermedin protects against renal ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress
Q36810822Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders
Q37328073Intracellular- and extracellular-derived Ca(2+) influence phospholipase A(2)-mediated fatty acid release from brain phospholipids
Q54640197Involvement of IRE1α signaling in the hippocampus in patients with mesial temporal lobe epilepsy
Q54025967Involvement of c-Fos in signaling grp78 induction following ER calcium release.
Q37225282Involvement of calcium-mediated reactive oxygen species in inductive GRP78 expression by geldanamycin in 9L rat brain tumor cells
Q43777394Iodoacetate protects hippocampal neurons against excitotoxic and oxidative injury: involvement of heat-shock proteins and Bcl-2.
Q35092168Kainic Acid-induced neurotoxicity: targeting glial responses and glia-derived cytokines.
Q35066729Lead-induced endoplasmic reticulum (ER) stress responses in the nervous system
Q82357390Localization of GRP78 to mitochondria under the unfolded protein response
Q64374854Long noncoding RNA UCA1 inhibits ischaemia/reperfusion injury induced cardiomyocytes apoptosis via suppression of endoplasmic reticulum stress
Q38056008Loss of endoplasmic reticulum Ca2+ homeostasis: contribution to neuronal cell death during cerebral ischemia
Q34332113Maintenance and neuronal cell differentiation of neural stem cells C17.2 correlated to medium availability sets design criteria in microfluidic systems
Q37140224Melatonin-Mediated Intracellular Insulin during 2-Deoxy-d-glucose Treatment Is Reduced through Autophagy and EDC3 Protein in Insulinoma INS-1E Cells.
Q74302745Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death
Q34711201Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior
Q28593131Molecular Components of a Cell Death Pathway Activated by Endoplasmic Reticulum Stress
Q35197096Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders
Q43712349Molecular analysis of endoplasmic reticulum stress response after global forebrain ischemia/reperfusion in rats: effect of neuroprotectant simvastatin.
Q39877564Molecular mechanisms leading to neuroprotection/ischemic tolerance: effect of preconditioning on the stress reaction of endoplasmic reticulum
Q34553820Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restriction
Q34514357Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death
Q41984401Mutation (D472Y) in the type 3 repeat domain of cartilage oligomeric matrix protein affects its early vesicle trafficking in endoplasmic reticulum and induces apoptosis
Q47786503Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma.
Q35196248Neuronal and glial calcium signaling in Alzheimer's disease
Q35051305Neuronal survival in the balance: are endoplasmic reticulum membrane proteins the fulcrum?
Q34105782Neuroprotective signaling and the aging brain: take away my food and let me run.
Q44574612Neurotoxicity induced by amyloid beta-peptide and ibotenic acid in organotypic hippocampal cultures: protection by S-allyl-L-cysteine, a garlic compound
Q27003450New cellular and molecular approaches to ageing brain
Q45207397Norepinephrine induces endoplasmic reticulum stress and downregulation of norepinephrine transporter density in PC12 cells via oxidative stress
Q38089680Novel interactions of GRP78: UPR and estrogen responses in the brain.
Q28580776OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes
Q28585440ORP150/HSP12A regulates Purkinje cell survival: a role for endoplasmic reticulum stress in cerebellar development
Q42594025Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress.
Q44606732Oxidative Damage to the Endoplasmic Reticulum is Implicated in Ischemic Neuronal Cell Death
Q31034776Oxidative-stress-related proteome changes in Helicobacter pylori-infected human gastric mucosa
Q27026528PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity
Q34040202Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) impairs the regulation of apoptosis in megakaryocytes by activating NF-κB: a proteomic study
Q92997601Presenilin 1 Regulates [Ca2+]i and Mitochondria/ER Interaction in Cultured Rat Hippocampal Neurons
Q40007417Progression of apoptic signaling from mesenteric ischemia-reperfusion injury to lungs: correlation in the level of ER chaperones expression
Q36045242Prophylactic activation of neuroprotective stress response pathways by dietary and behavioral manipulations
Q34364443Protection of taurine and granulocyte colony-stimulating factor against excitotoxicity induced by glutamate in primary cortical neurons
Q44426291Protective effect of S-allyl-l-cysteine, a garlic compound, on amyloid β-protein-induced cell death in nerve growth factor-differentiated PC12 cells
Q37044669Protein quality control in neurodegeneration: walking the tight rope between health and disease
Q34719880Proteomic analysis of primary cultured rat cortical neurons in chemical ischemia
Q45236966Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP78 and Bcl-2.
Q39576447RNA interference (RNAi) of Ufd1 protein can sensitize a hydroxycamptothecin-resistant colon cancer cell line SW1116/HCPT to hydroxycamptothecin
Q28260273Recent advances in methamphetamine neurotoxicity mechanisms and its molecular pathophysiology
Q34692778Regulation of ER stress proteins by valproate: therapeutic implications.
Q38410871Researching glutamate - induced cytotoxicity in different cell lines: a comparative/collective analysis/study
Q28366272Response of neurons to an irreversible inhibition of endoplasmic reticulum Ca(2+)-ATPase: relationship between global protein synthesis and expression and translation of individual genes
Q35123167Rifampicin protects PC12 cells from rotenone-induced cytotoxicity by activating GRP78 via PERK-eIF2α-ATF4 pathway
Q34117384Role of calcium in neuronal cell injury: which subcellular compartment is involved?
Q39231671Role of endoplasmic reticulum stress in light-induced photoreceptor degeneration in mice
Q37899563Role of glucose-regulated Protein 78 in embryonic development and neurological disorders.
Q45194005Role of the GABA-A system in estrogen-induced protection against brain lipid peroxidation in ethanol-withdrawn rats
Q42373415SYVN1, an ERAD E3 Ubiquitin Ligase, Is Involved in GABAAα1 Degradation Associated with Methamphetamine-Induced Conditioned Place Preference
Q57021107Sevoflurane relieves hepatic ischemia-reperfusion injury by inhibiting the expression of Grp78
Q30426463Single Prolonged Stress induces ATF6 alpha-dependent Endoplasmic reticulum stress and the apoptotic process in medial Frontal Cortex neurons
Q42275626Single-prolonged stress induces endoplasmic reticulum-dependent apoptosis in the hippocampus in a rat model of post-traumatic stress disorder
Q30872494Spirotetronate polyketides as leads in drug discovery
Q41354584Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells
Q37018677Syntaxin 5 Overexpression and β-Amyloid 1-42 Accumulation in Endoplasmic Reticulum of Hippocampal Cells in Rat Brain Induced by Ozone Exposure
Q21284187TNF-alpha mediates eosinophil cationic protein-induced apoptosis in BEAS-2B cells
Q39693413Targeting GRP78 to enhance melanoma cell death.
Q46315176Taurine Have Neuroprotective Activity against Oxidative Damage-Induced HT22 Cell Death through Heme Oxygenase-1 Pathway
Q41392048Taurine protection of PC12 cells against endoplasmic reticulum stress induced by oxidative stress
Q29999615Temporal linkage between the phenotypic and genomic responses to caloric restriction
Q41603023The anti-amnesic and neuroprotective effects of donepezil against amyloid beta25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor
Q34768726The endoplasmic reticulum as an integrating signalling organelle: from neuronal signalling to neuronal death
Q33882951The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice.
Q39937578The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated degradation pathway
Q80992836The involvement of copper transporter in lead-induced oxidative stress in astroglia
Q33774254The neuroprotective potential of heat shock protein 70 (HSP70).
Q24646616The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
Q40581127The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells
Q26799511The unfolded protein response in neurodegenerative diseases: a neuropathological perspective
Q39972647The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells
Q24626017Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder
Q44157472Treadmill exercise represses neuronal cell death and inflammation during Aβ-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice
Q37503671Tunicamycin-induced Endoplasmic Reticulum Stress Upregulates the Expression of Pentraxin 3 in Human Retinal Pigment Epithelial Cells
Q48553959Unfolded protein response is activated in the ipsilateral thalamus following focal cerebral infarction in hypertensive rats
Q47624762Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity
Q44297289Valproate inhibits oxidative damage to lipid and protein in primary cultured rat cerebrocortical cells
Q60530540β-Amyloid-induced calcium influx induces apoptosis in culture by oxidative stress rather than tau phosphorylation

Search more.