APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice.

scientific article published on 14 June 2017

APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/ICB.2017.48
P8608Fatcat IDrelease_ru6tyy63avatlhxsqbuke554qm
P698PubMed publication ID28611473

P50authorEmma E Hamilton-WilliamsQ55089467
Raymond J SteptoeQ59556035
F. Susan WongQ63411298
P2093author name stringXiao Liu
Rajeev Rudraraju
Peta Ls Reeves
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Allergen-encoding bone marrow transfer inactivates allergic T cell responses, alleviating airway inflammationQ33752348
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Interleukin-1β produced in response to islet autoantigen presentation differentiates T-helper 17 cells at the expense of regulatory T-cells: Implications for the timing of tolerizing immunotherapyQ34448684
Autoreactive effector/memory CD4+ and CD8+ T cells infiltrating grafted and endogenous islets in diabetic NOD mice exhibit similar T cell receptor usageQ34517586
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Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic MiceQ36255326
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CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunityQ36380997
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T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigensQ37202148
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Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic miceQ37323483
Memory CD8+ T cells exhibit increased antigen threshold requirements for recall proliferationQ37576718
Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejectionQ39933853
Peripheral Proinsulin Expression Controls Low-Avidity Proinsulin-Reactive CD8 T Cells in Type 1 Diabetes.Q40586866
The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cellsQ41146074
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Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector functionQ44234403
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Drug-interaction studies evaluating T-cell proliferation reveal distinct activity of dasatinib and imatinib in combination with cyclosporine A.Q47874171
Autoantigen-specific memory CD4+ T cells are prevalent early in progression to Type 1 diabetes.Q50971564
Steady-state antigen-expressing dendritic cells terminate CD4+ memory T-cell responses.Q51057483
Kinetic analysis of oral tolerance: memory lymphocytes are refractory to oral tolerance.Q52032008
Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells.Q53573163
CD8+ T cell tolerance in nonobese diabetic mice is restored by insulin-dependent diabetes resistance alleles.Q53850293
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NOD mice have a generalized defect in their response to transplantation tolerance induction.Q54095945
Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responsesQ57667259
Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic miceQ71909256
Chronic exposure to low levels of antigen in the periphery causes reversible functional impairment correlating with changes in CD5 levels in monoclonal CD8 T cellsQ73696450
Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetesQ81464244
Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetesQ82746957
P433issue9
P304page(s)765-774
P577publication date2017-06-14
P1433published inImmunology & Cell BiologyQ13731918
P1476titleAPC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice
P478volume95

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