Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment

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Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment is …
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P356DOI10.4049/JIMMUNOL.1701019
P8608Fatcat IDrelease_vgjxjrorejhuzbnhm4lvlwgece
P932PMC publication ID5765878
P698PubMed publication ID29311384

P50authorSuzanne Ostrand-RosenbergQ64683350
P2093author name stringCatherine Fenselau
P2860cites workChemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansionQ79441078
Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cellsQ80274418
TCR zeta down-regulation under chronic inflammation is mediated by myeloid suppressor cells differentially distributed between various lymphatic organsQ80284232
Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 responseQ80582229
CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cellsQ81598364
Granulocytic myeloid derived suppressor cells expand in human pregnancy and modulate T-cell responsesQ88012863
Inhibition of tumor-derived prostaglandin-e2 blocks the induction of myeloid-derived suppressor cells and recovers natural killer cell activityQ88035142
Development of splenic natural suppressor (NS) cells in Ehrlich tumor-bearing miceQ93516113
The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implicationsQ24605052
Myeloid-derived suppressor cells: linking inflammation and cancerQ24641811
Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 proteinQ24641894
Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cellsQ24658240
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standardsQ26744395
Regulation of tumor metastasis by myeloid-derived suppressor cellsQ27022125
Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differencesQ27027064
Myeloid-derived suppressor cells as regulators of the immune systemQ28131637
Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cellsQ28256749
ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosisQ28386923
The Nature of Myeloid-Derived Suppressor Cells in the Tumor MicroenvironmentQ28388630
Coordinated regulation of myeloid cells by tumoursQ28395157
Regulation of immune responses by L-arginine metabolismQ29614284
Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TANQ29619346
Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients.Q33564156
Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4+ and CD8+ T cellsQ33567728
Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteineQ33584867
Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cellsQ33604925
Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cellsQ33707270
Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cellsQ33816455
Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cellsQ33919954
Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cellsQ34060558
Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophilsQ34163579
Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor ProgressionQ34168497
The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumorsQ34228171
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironmentQ34243443
Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathwayQ34314210
HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cellsQ34353413
Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumorsQ34484057
The terminology issue for myeloid-derived suppressor cellsQ42425163
Peptide-based systems analysis of inflammation induced myeloid-derived suppressor cells reveals diverse signaling pathwaysQ42493330
Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumabQ44017442
Granulocytic myeloid-derived suppressor cells are cryosensitive and their frequency does not correlate with serum concentrations of colony-stimulating factors in head and neck cancerQ45344986
Surface Glycoproteins of Exosomes Shed by Myeloid-Derived Suppressor Cells Contribute to FunctionQ46064256
Interferon regulatory factor 4 (IRF4) controls myeloid-derived suppressor cell (MDSC) differentiation and functionQ46492738
Oxidative stress regulates expression of VEGFR1 in myeloid cells: link to tumor-induced immune suppression in renal cell carcinoma.Q46529900
Granulocytic Myeloid-Derived Suppressor Cells Accumulate in Human Placenta and Polarize toward a Th2 Phenotype.Q46617657
Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells.Q47100735
Ubiquitin Conjugation Probed by Inflammation in Myeloid-Derived Suppressor Cell Extracellular Vesicles.Q47615254
Frontline Science: Myeloid-derived suppressor cells (MDSCs) facilitate maternal-fetal tolerance in miceQ47910452
The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell ProductionQ48347565
Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune EvasionQ48769325
Evaluation of Spectral Counting for Relative Quantitation of Proteoforms in Top-Down ProteomicsQ48950646
High fat diet and leptin promote tumor progression by inducing myeloid-derived suppressor cellsQ49973501
Differential induction of hematopoiesis and immune suppressor cells in the bone marrow versus in the spleen by Lewis lung carcinoma variants.Q54164371
Tumor necrosis factor-α blocks differentiation and enhances suppressive activity of immature myeloid cells during chronic inflammation.Q54269192
Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor.Q54421148
Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing HostQ57054792
Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesisQ59276609
Identification of a New Subset of Myeloid Suppressor Cells in Peripheral Blood of Melanoma Patients With Modulation by a Granulocyte-Macrophage Colony-Stimulation Factor–Based Antitumor VaccineQ60311223
Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cellsQ71607047
Chemoattraction of femoral CD34+ progenitor cells by tumor-derived vascular endothelial cell growth factorQ73219365
Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancerQ73311980
Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivoQ77620517
Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and functionQ34616226
Proteomic pathway analysis reveals inflammation increases myeloid-derived suppressor cell resistance to apoptosisQ34616787
Ubiquitinated proteins in exosomes secreted by myeloid-derived suppressor cellsQ34669523
Tumor-induced myeloid dysfunction and its implications for cancer immunotherapyQ34810257
Modulation of the antitumor immune response by complementQ34838919
GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cellsQ34983887
Myeloid-derived suppressor cells express the death receptor Fas and apoptose in response to T cell-expressed FasLQ35029951
Gr-1+ CD11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesityQ35067909
Elevated endoplasmic reticulum stress reinforced immunosuppression in the tumor microenvironment via myeloid-derived suppressor cellsQ35067983
Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma modelQ35345202
Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in miceQ35370005
Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progressionQ35478848
Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells.Q35553327
Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing miceQ35648172
TGF-β receptor II loss promotes mammary carcinoma progression by Th17 dependent mechanismsQ35814020
IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function.Q36026855
Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrainedQ36186882
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancerQ36260673
Transcriptional regulation of myeloid-derived suppressor cellsQ36322351
TNF signaling drives myeloid-derived suppressor cell accumulationQ36357903
Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinomaQ36403544
A core of kinase-regulated interactomes defines the neoplastic MDSC lineageQ36413721
Unopposed production of granulocyte-macrophage colony-stimulating factor by tumors inhibits CD8+ T cell responses by dysregulating antigen-presenting cell maturation.Q36432026
Apoptotic death of CD8+ T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cellsQ36454468
γδT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer.Q36473289
Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor CellsQ36489379
Exosomes and tumor-mediated immune suppressionQ36737920
Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2.Q36767546
Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling.Q36963408
Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice.Q36982546
Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunityQ36996588
Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cellsQ37147482
G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse modelsQ37149710
Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axisQ37200858
Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4Q37232937
Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2.Q37317912
Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells.Q37325176
Induction of myeloid-derived suppressor cells by tumor exosomesQ37375966
Interferon regulatory factor-8 modulates the development of tumour-induced CD11b+Gr-1+ myeloid cells.Q37382352
Targeted STAT3 disruption in myeloid cells alters immunosuppressor cell abundance in a murine model of spontaneous medulloblastomaQ37496791
Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodesQ37544847
Exosomes from myeloid-derived suppressor cells carry biologically active proteinsQ37624283
Regulating the suppressors: apoptosis and inflammation govern the survival of tumor-induced myeloid-derived suppressor cells (MDSC).Q38006616
Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncologyQ38018279
Protumor and antitumor functions of neutrophil granulocytesQ38046098
Immunomonitoring and prognostic relevance of neutrophils in clinical trials.Q38080998
History of myeloid-derived suppressor cellsQ38141522
Myeloid-derived suppressor cell heterogeneity in human cancersQ38223250
Drafting the proteome landscape of myeloid-derived suppressor cells.Q38592376
Human neutrophils: Their role in cancer and relation to myeloid-derived suppressor cells.Q38805069
Tumor-Derived Exosomes and Their Role in Cancer ProgressionQ38818439
RORC1 Regulates Tumor-Promoting "Emergency" Granulo-MonocytopoiesisQ38844181
Axitinib augments antitumor activity in renal cell carcinoma via STAT3-dependent reversal of myeloid-derived suppressor cell accumulationQ38969799
Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progressionQ39087629
Mechanisms overseeing myeloid-derived suppressor cell production in neoplastic diseaseQ39146128
Melanoma-educated CD14+ cells acquire a myeloid-derived suppressor cell phenotype through COX-2-dependent mechanismsQ39158003
Blockade of Myd88 signaling induces antitumor effects by skewing the immunosuppressive function of myeloid-derived suppressor cellsQ39237839
Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth.Q39244686
Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF.Q39770285
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activityQ40013431
Natural Suppressor (NS) Cells, Neonatal Tolerance, and Total Lymphoid Irradiation: Exploring Obscure RelationshipsQ40097097
Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim studyQ40148008
Inflammation induces myeloid-derived suppressor cells that facilitate tumor progressionQ40338318
Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasisQ40339595
High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cellsQ40519826
Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer.Q40605195
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells.Q41974388
Suppression of cytotoxic T-cell generation by natural suppressor cells from mice with GVHD is partially reversed by indomethacinQ42160714
Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samplesQ42219156
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)422-431
P577publication date2018-01-01
P1433published inJournal of ImmunologyQ3521441
P1476titleMyeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment
P478volume200

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