Cangene gold medal award lecture - Genomic analysis and modification of Burkholderia cepacia complex bacteriophages.

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Cangene gold medal award lecture - Genomic analysis and modification of Burkholderia cepacia complex bacteriophages. is …
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P356DOI10.1139/W11-135
P698PubMed publication ID22339239
P5875ResearchGate publication ID221836895

P50authorJonathan J DennisQ56426771
P2093author name stringKarlene H Lynch
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Analysis of high-throughput sequencing and annotation strategies for phage genomesQ30483489
Burkholderia ambifaria sp. nov., a novel member of the Burkholderia cepacia complex including biocontrol and cystic fibrosis-related isolatesQ30658029
5500 Phages examined in the electron microscopeQ33260858
Burkholderia latens sp. nov., Burkholderia diffusa sp. nov., Burkholderia arboris sp. nov., Burkholderia seminalis sp. nov. and Burkholderia metallica sp. nov., novel species within the Burkholderia cepacia complexQ33348917
Preparation of a phage DNA fragment library for whole genome shotgun sequencingQ33392951
Genomic sequence and activity of KS10, a transposable phage of the Burkholderia cepacia complexQ33394398
Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp. nov. and Burkholderia lata sp. nov.Q33397958
Quality-controlled small-scale production of a well-defined bacteriophage cocktail for use in human clinical trialsQ33419859
Efficacy of bacteriophage therapy in a model of Burkholderia cenocepacia pulmonary infectionQ33622945
Genetic and phenotypic diversity in Burkholderia: contributions by prophage and phage-like elementsQ33643800
Genomic analysis and relatedness of P2-like phages of the Burkholderia cepacia complexQ33727287
Serotype-converting bacteriophages and O-antigen modification in Shigella flexneriQ33818885
The complete nucleotide sequence of phi CTX, a cytotoxin-converting phage of Pseudomonas aeruginosa: implications for phage evolution and horizontal gene transfer via bacteriophagesQ33852693
Comparative phage genomics and the evolution of Siphoviridae: insights from dairy phagesQ33929777
Lysogenic conversion by a filamentous phage encoding cholera toxinQ34062735
The genome sequence of Clostridium botulinum type C neurotoxin-converting phage and the molecular mechanisms of unstable lysogenyQ34132692
The prospect for bacteriophage therapy in Western medicineQ34201438
Divergence and mosaicism among virulent soil phages of the Burkholderia cepacia complexQ34233220
Multidrug-resistant enterococci lack CRISPR-casQ34285916
Old dogma, new tricks--21st Century phage therapyQ34287638
Conserved translational frameshift in dsDNA bacteriophage tail assembly genes.Q34356558
Phages of dairy bacteriaQ34360779
Structural analysis of dispersin B, a biofilm-releasing glycoside hydrolase from the periodontopathogen Actinobacillus actinomycetemcomitansQ34416551
Comparative genomics and evolution of the tailed-bacteriophages.Q34433982
Effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa.Q34483463
Mucociliary clearance in cystic fibrosisQ34581003
Unifying classical and molecular taxonomic classification: analysis of the Podoviridae using BLASTP-based toolsQ34786602
Use of genetically engineered phage to deliver antimicrobial agents to bacteria: an alternative therapy for treatment of bacterial infections.Q34885744
Prevalence, conservation and functional analysis of Yersinia and Escherichia CRISPR regions in clinical Pseudomonas aeruginosa isolatesQ34954589
Common themes among bacteriophage-encoded virulence factors and diversity among the bacteriophages involvedQ34990712
Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trial.Q34996099
Genomes and characterization of phages Bcep22 and BcepIL02, founders of a novel phage type in Burkholderia cenocepaciaQ35274632
Burkholderia cenocepacia and Burkholderia multivorans: influence on survival in cystic fibrosis.Q35536317
Population and evolutionary dynamics of phage therapyQ35709197
Case studies of the spatial heterogeneity of DNA viruses in the cystic fibrosis lungQ35991304
Epidemiology of Burkholderia cepacia complex in patients with cystic fibrosis, CanadaQ36014916
Role of phages in the pathogenesis of Burkholderia, or 'Where are the toxin genes in Burkholderia phages?'.Q36118037
Isolation measures for prevention of infection with respiratory pathogens in cystic fibrosis: a systematic review.Q36533618
Comparative genomics and an insect model rapidly identify novel virulence genes of Burkholderia malleiQ36540498
Prediction of lipoprotein signal peptides in Gram-negative bacteriaQ36572165
Burkholderia gladioli: five year experience in a cystic fibrosis and lung transplantation centerQ36669829
Lipid A acylation and bacterial resistance against vertebrate antimicrobial peptides.Q36899142
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patientsQ37033480
Genomic analysis of an emerging multiresistant Staphylococcus aureus strain rapidly spreading in cystic fibrosis patients revealed the presence of an antibiotic inducible bacteriophageQ37069059
The biofilm life cycle and virulence of Pseudomonas aeruginosa are dependent on a filamentous prophageQ37111067
Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapyQ37114251
Preventing biofilms of clinically relevant organisms using bacteriophageQ37375379
CRISPR-based adaptive and heritable immunity in prokaryotesQ37568446
Mycobacteriophages: genes and genomesQ37763219
Studying bacterial transcriptomes using RNA-seqQ37796158
Classification and identification of the Burkholderia cepacia complex: Past, present and futureQ37831692
Bacteriophages for the treatment of Pseudomonas aeruginosa infectionsQ37853657
Predicting genes expressed via -1 and +1 frameshiftsQ38516411
Lysis-deficient phages as novel therapeutic agents for controlling bacterial infectionQ39374494
Reduction in exopolysaccharide viscosity as an aid to bacteriophage penetration through Pseudomonas aeruginosa biofilmsQ39491332
In vitro lung delivery of bacteriophages KS4-M and ΦKZ using dry powder inhalers for treatment of Burkholderia cepacia complex and Pseudomonas aeruginosa infections in cystic fibrosisQ39833543
Therapy of experimental pseudomonas infections with a nonreplicating genetically modified phageQ40164333
Characterization of DC1, a broad-host-range Bcep22-like podovirusQ40598053
Killing of Mycobacterium avium and Mycobacterium tuberculosis by a mycobacteriophage delivered by a nonvirulent mycobacterium: a model for phage therapy of intracellular bacterial pathogensQ40629899
Pseudomonas cepacia infection in cystic fibrosis: an emerging problemQ40829590
Intracellular survival of Burkholderia cepacia complex isolates in the presence of macrophage cell activationQ40907519
Burkholderia cepacia: medical, taxonomic and ecological issuesQ41260421
The population biology of bacterial viruses: why be temperateQ41577540
A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo.Q41857195
Elucidating global epidemiology of Burkholderia multivorans in cases of cystic fibrosis by multilocus sequence typing.Q41913539
Experimental bacteriophage therapy increases survival of Galleria mellonella larvae infected with clinically relevant strains of the Burkholderia cepacia complex.Q42026295
Development of a species-specific fur gene-based method for identification of the Burkholderia cepacia complexQ42083986
High-temperature-induced transposition of insertion elements in burkholderia multivorans ATCC 17616Q42122691
Inactivation of Burkholderia cepacia complex phage KS9 gp41 identifies the phage repressor and generates lytic virionsQ42216737
Antimicrobial susceptibility and synergy studies of Burkholderia cepacia complex isolated from patients with cystic fibrosisQ42948700
Isolation of Burkholderia cenocepacia and Burkholderia vietnamiensis from human sewage.Q43368859
In vitro activity of ceftazidime, ciprofloxacin, meropenem, minocycline, tobramycin and trimethoprim/sulfamethoxazole against planktonic and sessile Burkholderia cepacia complex bacteriaQ43618599
Genetically modified filamentous phage as bactericidal agents: a pilot studyQ43814540
N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms.Q43820097
Community-acquired bacteremic Pseudomonas cepacia pneumonia in an immunocompetent hostQ44045761
P433issue3
P921main subjectBurkholderia cepaciaQ139227
bacteriophageQ165028
P304page(s)221-235
P577publication date2012-02-17
P1433published inCanadian Journal of MicrobiologyQ15752448
P1476titleCangene gold medal award lecture - Genomic analysis and modification of Burkholderia cepacia complex bacteriophages
P478volume58

Reverse relations

cites work (P2860)
Q38020842Bacteriophage based probes for pathogen detection.
Q34296269Comparative analysis of two phenotypically-similar but genomically-distinct Burkholderia cenocepacia-specific bacteriophages
Q34974472Genomic characterization of JG068, a novel virulent podovirus active against Burkholderia cenocepacia.
Q37313625Identification and characterization of ϕH111-1: A novel myovirus with broad activity against clinical isolates of Burkholderia cenocepacia
Q28076246Modular Approach to Select Bacteriophages Targeting Pseudomonas aeruginosa for Their Application to Children Suffering With Cystic Fibrosis

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