Sympatholytic effect of intravascular ATP is independent of nitric oxide, prostaglandins, Na+ /K+ -ATPase and KIR channels in humans

scientific article published on 7 June 2017

Sympatholytic effect of intravascular ATP is independent of nitric oxide, prostaglandins, Na+ /K+ -ATPase and KIR channels in humans is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1113/JP274532
P932PMC publication ID5538228
P698PubMed publication ID28590059

P50authorFrank A DinennoQ88231966
P2093author name stringMichael J Joyner
Dennis G Larson
Gary J Luckasen
Jennifer C Richards
Christopher M Hearon
Mathew L Racine
P2860cites workErythrocyte-derived ATP and perfusion distribution: role of intracellular and intercellular communicationQ24598135
Role for endothelial cell conduction in ascending vasodilatation and exercise hyperaemia in hamster skeletal muscleQ28363241
Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators.Q30277617
Endothelial Ca2+ wavelets and the induction of myoendothelial feedbackQ30513557
Inhibition of alpha-adrenergic vasoconstriction in exercising human thigh musclesQ31034272
Exercise attenuates alpha-adrenergic-receptor responsiveness in skeletal muscle vasculatureQ31776933
Exogenous NO administration and alpha-adrenergic vasoconstriction in human limbsQ33188181
Adenosine activates ATP-sensitive potassium channels in arterial myocytes via A2 receptors and cAMP-dependent protein kinaseQ33680087
Augmented pressor and sympathetic responses to skeletal muscle metaboreflex activation in type 2 diabetes patientsQ33891361
KIR channel activation contributes to onset and steady-state exercise hyperemia in humansQ34296753
Nitric oxide, but not vasodilating prostaglandins, contributes to the improvement of exercise hyperemia via ascorbic acid in healthy older adultsQ34357850
The paradox of sympathetic vasoconstriction in exercising skeletal muscleQ34425925
Pharmacology of adenosine receptors in the vasculatureQ34453222
Potassium channels in the peripheral microcirculationQ34461421
Activation of two sites by adenosine receptor agonists to cause relaxation in rat isolated mesenteric arteryQ35026945
Local release of ATP into the arterial inflow and venous drainage of human skeletal muscle: insight from ATP determination with the intravascular microdialysis techniqueQ60637770
Regional vascular resistance vs. conductance: which index for baroreflex responses?Q68201043
Differential sensitivity of arteriolar alpha 1- and alpha 2-adrenoceptor constriction to metabolic inhibition during rat skeletal muscle contractionQ68241246
A dual function for adenosine 5'-triphosphate in the regulation of vascular tone. Excitatory cotransmitter with noradrenaline from perivascular nerves and locally released inhibitory intravascular agentQ70142019
Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factorQ71958396
Interaction between conducted vasodilation and sympathetic nerve activation in arterioles of hamster striated muscleQ72187923
Inhibition of alpha 2-adrenergic vasoconstriction during contraction of glycolytic, not oxidative, rat hindlimb muscleQ72675196
Vasodilation to bradykinin is mediated by an ouabain-sensitive pathway as a compensatory mechanism for impaired nitric oxide availability in essential hypertensive patientsQ73026267
Gender differences in sensitivity to adrenergic agonists of forearm resistance vasculatureQ73069737
Having it both ways? Vasoconstriction in contracting musclesQ73459148
Nitric oxide mediates contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscleQ74315971
alpha1-adrenergic-receptor responsiveness in skeletal muscle during dynamic exerciseQ77648901
Blood pressure during supine exercise in idiopathic orthostatic hypotensionQ79068596
Functional sympatholysis during muscular activity. Observations on influence of carotid sinus on oxygen uptakeQ79635280
Spreading dilatation to luminal perfusion of ATP and UTP in rat isolated small mesenteric arteriesQ80263814
Mechanical effects of muscle contraction do not blunt sympathetic vasoconstriction in humansQ81795827
Modulation of postjunctional α-adrenergic vasoconstriction during exercise and exogenous ATP infusions in ageing humansQ83842055
Combined inhibition of nitric oxide and vasodilating prostaglandins abolishes forearm vasodilatation to systemic hypoxia in healthy humansQ83842182
ATP-mediated vasodilatation occurs via activation of inwardly rectifying potassium channels in humansQ84552796
Contracting human skeletal muscle maintains the ability to blunt α1 -adrenergic vasoconstriction during KIR channel and Na(+) /K(+) -ATPase inhibitionQ87153080
ATP-induced vasodilation in human skeletal muscleQ35046189
Mechanisms of ATP-mediated vasodilation in humans: modest role for nitric oxide and vasodilating prostaglandinsQ35395499
Impaired skeletal muscle blood flow control with advancing age in humans: attenuated ATP release and local vasodilation during erythrocyte deoxygenationQ36086617
Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilationQ37139803
Mechanism of ATP-induced local and conducted vasomotor responses in isolated rat cerebral penetrating arteriolesQ37169597
What's where and why at a vascular myoendothelial microdomain signalling complex.Q37329195
ATP-sensitive potassium channels mediate contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle.Q37367976
Reactive hyperemia occurs via activation of inwardly rectifying potassium channels and Na+/K+-ATPase in humansQ37410493
Regulation of blood flow distribution in skeletal muscle: role of erythrocyte-released ATP.Q38010153
Intravascular ATP and the regulation of blood flow and oxygen delivery in humansQ38267534
Small- and intermediate-conductance Ca2+-activated K+ channels directly control agonist-evoked nitric oxide synthesis in human vascular endothelial cellsQ40140916
Conducted dilatation to ATP and K+ in rat skeletal muscle arteriolesQ40813751
Neural control of muscle blood flow: importance during dynamic exerciseQ41389735
Prolonged adenosine triphosphate infusion and exercise hyperemia in humansQ42089069
Vasodilatory responsiveness to adenosine triphosphate in ageing humansQ42921063
Crucial importance of the endothelial K+ channel SK3 and connexin40 in arteriolar dilations during skeletal muscle contractionQ43081572
An indirect influence of phenylephrine on the release of endothelium-derived vasodilators in rat small mesenteric arteryQ43262057
Different pathways with distinct properties conduct dilations in the microcirculation in vivoQ43263713
beta-Receptor agonist activity of phenylephrine in the human forearmQ43572844
Impaired modulation of sympathetic vasoconstriction in contracting skeletal muscle of rats with chronic myocardial infarctions: role of oxidative stress.Q43590611
Activation of barium-sensitive inward rectifier potassium channels mediates remote dilation of coronary arteriolesQ43760012
Is sympathetic neural vasoconstriction blunted in the vascular bed of exercising human muscle?Q44013303
Erythrocyte and the regulation of human skeletal muscle blood flow and oxygen delivery: role of circulating ATP.Q44232562
alpha1- and alpha2-adrenergic vasoconstriction is blunted in contracting human muscleQ44317055
Conducted dilations initiated by purines in arterioles are endothelium dependent and require endothelial Ca2+.Q44362057
Augmented leg vasoconstriction in dynamically exercising older men during acute sympathetic stimulationQ44489960
Elevated non-esterified fatty acids impair nitric oxide independent vasodilation, in humans: evidence for a role of inwardly rectifying potassium channelsQ44512729
Blunted sympathetic vasoconstriction in contracting skeletal muscle of healthy humans: is nitric oxide obligatory?Q44569252
Activation of ATP/UTP-selective receptors increases blood flow and blunts sympathetic vasoconstriction in human skeletal muscleQ44585114
Myoendothelial gap junctions may provide the pathway for EDHF in mouse mesenteric artery.Q44635576
Local inhibition of nitric oxide and prostaglandins independently reduces forearm exercise hyperaemia in humansQ44816935
Circulating ATP-induced vasodilatation overrides sympathetic vasoconstrictor activity in human skeletal muscleQ44904872
Combined NO and PG inhibition augments alpha-adrenergic vasoconstriction in contracting human skeletal muscleQ44991344
Inhibition of KATP channel activity augments baroreflex-mediated vasoconstriction in exercising human skeletal muscleQ45042747
Functional sympatholysis is impaired in hypertensive humans.Q45387746
Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivoQ46121556
ATP-induced vasodilation and purinergic receptors in the human leg: roles of nitric oxide, prostaglandins, and adenosineQ46178223
Graded sympatholytic effect of exogenous ATP on postjunctional alpha-adrenergic vasoconstriction in the human forearm: implications for vascular control in contracting muscleQ46490402
Nitric oxide-dependent modulation of sympathetic neural control of oxygenation in exercising human skeletal muscle.Q49148880
Endothelium-dependent vasodilatory signalling modulates α1 -adrenergic vasoconstriction in contracting skeletal muscle of humans.Q51550205
Inward rectifying potassium channels facilitate cell-to-cell communication in hamster retractor muscle feed arteries.Q51808475
Interaction between sympathetic nerve activation and muscle fibre contraction in resistance vessels of hamster retractor muscle.Q51837145
Nitric oxide contributes to the rise in forearm blood flow during mental stress in humans.Q52022552
cAMP-independent dilation of coronary arterioles to adenosine : role of nitric oxide, G proteins, and K(ATP) channels.Q52536526
K+ is an endothelium-derived hyperpolarizing factor in rat arteries.Q54114747
Characterization of ATP-induced vasodilation in the human forearm vascular bed.Q54193800
Resistance or conductance for expression of arterial vascular tone.Q54358451
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)5175-5190
P577publication date2017-06-07
P1433published inJournal of PhysiologyQ7743612
P1476titleSympatholytic effect of intravascular ATP is independent of nitric oxide, prostaglandins, Na+ /K+ -ATPase and KIR channels in humans
P478volume595

Reverse relations

cites work (P2860)
Q90147709Amplification of endothelium-dependent vasodilatation in contracting human skeletal muscle: role of KIR channels
Q64117599Difference in the integrated effects of sympathetic vasoconstriction and local vasodilation in human skeletal muscle and skin microvasculature
Q52617366Inhibition of Na+ /K+ -ATPase and KIR channels abolishes hypoxic hyperaemia in resting but not contracting skeletal muscle of humans.
Q88740250KIR channels mediate vasodilation but not sympatholysis
Q45071370Probenecid Inhibits α-Adrenergic Receptor-Mediated Vasoconstriction in the Human Leg Vasculature.
Q55399934Prostaglandins in the pathogenesis of kidney diseases.
Q48186604Sympatholysis: the more we learn, the less we know

Search more.