Activated B Cells Participating in the Anti-Myelin Response Are Excluded from the Inflamed Central Nervous System in a Model of Autoimmunity that Allows for B Cell Recognition of Autoantigen

scientific article published on 5 June 2017

Activated B Cells Participating in the Anti-Myelin Response Are Excluded from the Inflamed Central Nervous System in a Model of Autoimmunity that Allows for B Cell Recognition of Autoantigen is …
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scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1602042
P698PubMed publication ID28584006

P50authorSteven M. KerfootQ42322197
Rajiv JainQ96248698
P2093author name stringYodit Tesfagiorgis
Sarah L Zhu
P2860cites workMeningeal Tertiary Lymphoid Tissues and Multiple Sclerosis: A Gathering Place for Diverse Types of Immune Cells during CNS AutoimmunityQ26770380
B Cells Are Multifunctional Players in Multiple Sclerosis Pathogenesis: Insights from Therapeutic InterventionsQ26770664
B Cells in the Multiple Sclerosis Central Nervous System: Trafficking and Contribution to CNS-Compartmentalized InflammationQ26770852
Multiple sclerosis-a quiet revolutionQ26826930
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Basic principles of immunological surveillance of the normal central nervous systemQ34398602
Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosisQ34538912
Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation.Q35009513
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Germinal center B cell and T follicular helper cell development initiates in the interfollicular zoneQ35758747
Central Nervous System and Peripheral Expression of CCL19, CCL21 and Their Receptor CCR7 in Experimental Model of Multiple SclerosisQ36065424
Meningeal Infiltration of the Spinal Cord by Non-Classically Activated B Cells is Associated with Chronic Disease Course in a Spontaneous B Cell-Dependent Model of CNS Autoimmune DiseaseQ36097332
Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammationQ36174679
Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived ImmunoglobulinsQ36330016
Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis.Q36370963
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B cells and antibodies in multiple sclerosis pathogenesis and therapyQ38050398
B cell follicle-like structures in multiple sclerosis-with focus on the role of B cell activating factor.Q38222302
Memory B Cells of Mice and HumansQ39112119
B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic miceQ41028078
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Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell responseQ43887998
Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 miceQ44484576
B-cell enrichment and Epstein-Barr virus infection in inflammatory cortical lesions in secondary progressive multiple sclerosisQ45353475
Diversity among memory B cells: origin, consequences, and utility.Q46918689
Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis.Q47357498
Memory B-cell persistence is independent of persisting immunizing antigen.Q47821945
Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology.Q48200750
Dynamic changes in meningeal inflammation correspond to clinical exacerbations in a murine model of relapsing-remitting multiple sclerosisQ48373501
Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosisQ48949792
B cell recognition of myelin oligodendrocyte glycoprotein autoantigen depends on immunization with protein rather than short peptide, while B cell invasion of the CNS in autoimmunity does not.Q50283688
Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.Q51027456
Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesionsQ59070288
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)449-457
P577publication date2017-06-05
P1433published inJournal of ImmunologyQ3521441
P1476titleActivated B Cells Participating in the Anti-Myelin Response Are Excluded from the Inflamed Central Nervous System in a Model of Autoimmunity that Allows for B Cell Recognition of Autoantigen
P478volume199

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Q55512364B cells are capable of independently eliciting rapid reactivation of encephalitogenic CD4 T cells in a murine model of multiple sclerosis.cites workP2860

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