Primary structure of beta-galactoside alpha 2,6-sialyltransferase. Conversion of membrane-bound enzyme to soluble forms by cleavage of the NH2-terminal signal anchor

scientific article published in December 1987

Primary structure of beta-galactoside alpha 2,6-sialyltransferase. Conversion of membrane-bound enzyme to soluble forms by cleavage of the NH2-terminal signal anchor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0021-9258(18)45441-5
P698PubMed publication ID3121604

P2093author name stringJ C Paulson
J Weinstein
K McEntee
Paulson JC
McEntee K
P H Lai
Weinstein J
E U Lee
Lai PH
Lee EU
P2860cites workDNA sequencing with chain-terminating inhibitorsQ22066207
Molecular genetics of human color vision: the genes encoding blue, green, and red pigmentsQ24294339
Immunocytochemical localization of galactosyltransferase in HeLa cells: codistribution with thiamine pyrophosphatase in trans-Golgi cisternaeQ24300756
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseQ26778460
2 New M13 vectors for cloningQ27861042
Multiple upstream AUG codons mediate translational control of GCN4.Q27929995
Molecular cloning and chromosomal localization of human 4-beta-galactosyltransferaseQ28116025
Primary structure of human transferrin receptor deduced from the mRNA sequenceQ28119131
Assembly of asparagine-linked oligosaccharidesQ28131690
Structure of the neuraminidase gene in human influenza virus A/PR/8/34Q28276795
Isolation of a cDNA coding for human galactosyltransferaseQ28290124
Prediction of protein antigenic determinants from amino acid sequencesQ29547548
Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesisQ29547610
RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexaminationQ29547816
Signal sequences. The limits of variationQ29616543
Bovine galactosyltransferase: identification of a clone by direct immunological screening of a cDNA expression libraryQ31142764
Selection of initiation sites by eucaryotic ribosomes: effect of inserting AUG triplets upstream from the coding sequence for preproinsulinQ35278976
Cloning and sequencing of cDNA of bovine N-acetylglucosamine (beta 1-4)galactosyltransferaseQ35614333
Orientation of glycoprotein galactosyltransferase and sialyltransferase enzymes in vesicles derived from rat liver Golgi apparatusQ36204312
Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequenceQ36587130
Localization of galactosyl- and sialyltransferase by immunofluorescence: evidence for different sitesQ37541045
5' untranslated sequences are required for the translational control of a yeast regulatory geneQ37563115
Evidence for translational regulation of the activator of general amino acid control in yeastQ37573526
Compartmental organization of the Golgi stackQ39847933
Elevated glycosyltransferase activities in infected or traumatized hosts: nonspecific response to inflammationQ40860653
Seminal Plasma Biochemistry II Seminal Plasma and Spermatozoal Cytidine Monophosphate-Sialic Acid Synthetase and Sialyltransferase ActivitiesQ42245202
Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphomaQ44720768
Multiple mechanisms of protein insertion into and across membranes.Q53779152
Identification of human glucocorticoid receptor complementary DNA clones by epitope selectionQ56911569
The preparation and characterization of two forms of bovine galactosyl transferaseQ68361348
Porcine sugar nucleotide: glycoprotein glycosyltransferases. I. Blood serum and liver sialyltransferaseQ68627315
Activity and secretion of sialyltransferase in primary monolayer cultures of rat hepatocytes cultured with and without dexamethasoneQ69539765
Demonstration of an extensive trans-tubular network continuous with the Golgi apparatus stack that may function in glycosylationQ70117847
Elevated sialyltransferase activity in the intestinal lymph of colchicine-treated ratsQ70754224
Protein sequence analysis: automated microsequencingQ71243315
P433issue36
P407language of work or nameEnglishQ1860
P1104number of pages9
P304page(s)17735-17743
P577publication date1987-12-01
P1433published inJournal of Biological ChemistryQ867727
P1476titlePrimary structure of beta-galactoside alpha 2,6-sialyltransferase. Conversion of membrane-bound enzyme to soluble forms by cleavage of the NH2-terminal signal anchor
P478volume262

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cites work (P2860)
Q3709382713C-sialic acid labeling of glycans on glycoproteins using ST6Gal-I.
Q24305321A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4
Q73270989A novel subset of murine B cells that expresses unmasked forms of CD22 is enriched in the bone marrow: implications for B-cell homing to the bone marrow
Q26827579A perspective on the structure and receptor binding properties of immunoglobulin G Fc
Q44176615A solid-phase assay for the activity of CMPNeuAc:Gal β1-4GlcNAc-R α-2,6-sialyltransferase
Q50755716A soluble form of Sda-beta 1,4-N-acetylgalactosaminyltransferase is released by differentiated human colon carcinoma CaCo-2 cells.
Q33694538Altered eosinophil profile in mice with ST6Gal-1 deficiency: an additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation
Q35848710Altered granulopoietic profile and exaggerated acute neutrophilic inflammation in mice with targeted deficiency in the sialyltransferase ST6Gal I
Q35671120Alzheimer's beta-secretase cleaves a glycosyltransferase as a physiological substrate
Q33949840Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase
Q24598282An investigation of the role of transmembrane domains in Golgi protein retention
Q24322919Analysis of the substrate binding sites of human galactosyltransferase by protein engineering
Q83230248B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism
Q37065114B-cell-independent sialylation of IgG.
Q71470654Biosynthesis in vitro of neolactotetraosylceramide by a galactosyltransferase from mouse T-lymphoma: purification and kinetic studies; synthesis of neolacto and polylactosamine core
Q42583191Branch-specific sialylation of IgG-Fc glycans by ST6Gal-I.
Q28260435CD22: an inhibitory enigma
Q72091225CDw75 Antigen Expression in Breast Lesions
Q37434568CMP substitutions preferentially inhibit polysialic acid synthesis
Q78757823Clinicopathologic evaluation of CDw75 antigen expression in colorectal adenocarcinomas
Q24563854Cloning and analysis of the Saccharomyces cerevisiae MNN9 and MNN1 genes required for complex glycosylation of secreted proteins
Q36812392Cloning and expression of a porcine UDP-GalNAc: polypeptide N-acetylgalactosaminyl transferase
Q24633703Complete cDNA sequence encoding human beta-galactoside alpha-2,6-sialyltransferase
Q33269110Complete primary structure of porcine tenascin. Detection of tenascin transcripts in adult submaxillary glands
Q33269616Construction and characterization of new piggyBac vectors for constitutive or inducible expression of heterologous gene pairs and the identification of a previously unrecognized activator sequence in piggyBac.
Q72459645Different sialyltransferase activities in human colorectal carcinoma cells from surgical specimens detected by specific glycoprotein and glycolipid acceptors
Q92282635Direct fluorescent glycan labeling with recombinant sialyltransferases
Q43993993Direct interference with rhamnogalacturonan I biosynthesis in Golgi vesicles
Q30873680Engineering the protein N-glycosylation pathway in insect cells for production of biantennary, complex N-glycans.
Q34785036Engineering β1,4-galactosyltransferase I to reduce secretion and enhance N-glycan elongation in insect cells
Q67727848Enhanced CMP-NeuAc:Galβ1, 4GlcNAc-R α2, 6 sialyltransferase activity of human colon cancer xenografts in athymic nude mice and of xenograft-derived cell lines
Q27680447Enzymatic Basis for N-Glycan Sialylation: STRUCTURE OF RAT  2,6-SIALYLTRANSFERASE (ST6GAL1) REVEALS CONSERVED AND UNIQUE FEATURES FOR GLYCAN SIALYLATION
Q39290505Epigenetic Bases of Aberrant Glycosylation in Cancer
Q39993642Evidence for a sialic acid salvaging pathway in lepidopteran insect cells
Q90222396Exploration of the Sialic Acid World
Q24564218Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells
Q34293809Expression of bovine beta-1,4-galactosyltransferase cDNA in COS-7 cells
Q53398450Expression of the CDw75 (beta-galactoside alpha 2,6-sialyltransferase) antigen on normal blood cells and in B-cell chronic lymphocytic leukaemia
Q107349299Fluorescent Glycan Fingerprinting of SARS2 Spike Proteins
Q47070983Functional Characterization of Drosophila Sialyltransferase
Q36290900Functional aspects of glycoprotein N-linked oligosaccharide processing by human tumours
Q35131855Gene silencing of β-galactosamide α-2,6-sialyltransferase 1 inhibits human influenza virus infection of airway epithelial cells
Q46375292Genetic engineering of CHO cells producing human interferon-gamma by transfection of sialyltransferases
Q33804543Genetic engineering of recombinant glycoproteins and the glycosylation pathway in mammalian host cells
Q41240945Genetic engineering of α2,6-sialyltransferase in recombinant CHO cells and its effects on the sialylation of recombinant interferon-γ.
Q37760983Glycosylation in intestinal epithelium
Q42608228High-quality production of human α-2,6-sialyltransferase in Pichia pastoris requires control over N-terminal truncations by host-inherent protease activities
Q44590822Human-specific Regulation of α2–6-linked Sialic Acids
Q36368171Identification of CD22 ligands on bone marrow sinusoidal endothelium implicated in CD22-dependent homing of recirculating B cells
Q35579621Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells
Q38288653Identification of the gonococcal glmU gene encoding the enzyme N-acetylglucosamine 1-phosphate uridyltransferase involved in the synthesis of UDP-GlcNAc
Q88445153IgG and leukocytes: Targets of immunomodulatory α2,6 sialic acids
Q36475650Immune regulation by the ST6Gal sialyltransferase
Q36815622Improved glycosylation of a foreign protein by Tn-5B1-4 cells engineered to express mammalian glycosyltransferases.
Q31118826Involvement of proteases in glycosyltransferase secretion: Alzheimer's beta-secretase-dependent cleavage and a following processing by an aminopeptidase
Q34314796Isolation of a cDNA encoding a murine UDPgalactose:beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase: expression cloning by gene transfer
Q34335605Isolation of a matrix that binds medial Golgi enzymes
Q34289604Isolation of a rat liver Golgi mannosidase II clone by mixed oligonucleotide-primed amplification of cDNA.
Q24644108Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans
Q46155748Large-scale expression of recombinant sialyltransferases and comparison of their kinetic properties with native enzymes
Q48052178Localization of beta-galactoside alpha2,6-sialyltransferase gene on pig chromosome 13q4.1.
Q40990270Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels
Q33318026Molecular cloning and expression of cDNA encoding the enzyme that controls conversion of high-mannose to hybrid and complex N-glycans: UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I
Q24336308Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion
Q24321389Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen
Q37464201Nuclear magnetic resonance structural characterization of substrates bound to the alpha-2,6-sialyltransferase, ST6Gal-I.
Q27938727OCH1 encodes a novel membrane bound mannosyltransferase: outer chain elongation of asparagine-linked oligosaccharides
Q35796018Ovarian angiogenesis. Phenotypic characterization of endothelial cells in a physiological model of blood vessel growth and regression
Q39663097Overexpression of amyloid beta precursor protein enhances expression and secretion of ST6Gal1 in C2C12 myogenic cell line
Q36217283Peptide-specific transfer of N-acetylgalactosamine to O-linked glycans by the glycosyltransferases β1,4-N-acetylgalactosaminyl transferase 3 (β4GalNAc-T3) and β4GalNAc-T4
Q35909612Polyoma and hamster papovavirus large T antigen-mediated replication of expression shuttle vectors in Chinese hamster ovary cells
Q34294088Predicting the orientation of eukaryotic membrane-spanning proteins
Q41153052Protein glycosylation in the endoplasmic reticulum and the Golgi apparatus and cell type-specificity of cell surface glycoconjugate expression: analysis by the protein A-gold and lectin-gold techniques
Q28114903Purification and cDNA Cloning of a Human UDP-N-acetyl-α- D-galactosamine:polypeptide N-Acetylgalactosaminyltransferase
Q34404844Regulation of CD45 engagement by the B-cell receptor CD22.
Q41057192Secretion of alpha1,3-galactosyltransferase by cultured cells and presence of enzyme in animal sera
Q67780963Secretion of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from cultured chick embryo chondrocytes
Q41083198Sequences within and adjacent to the transmembrane segment of alpha-2,6-sialyltransferase specify Golgi retention
Q34807554Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation
Q39038778Sialylation of N-glycans: mechanism, cellular compartmentalization and function.
Q35160084Sialyltransferases in cancer
Q38446053Significance of β-Galactoside α2,6 Sialyltranferase 1 in Cancers.
Q37670596Spin-labeled analogs of CMP-NeuAc as NMR probes of the alpha-2,6-sialyltransferase ST6Gal I.
Q38315869Studies on the effect of mevinolin (lovastatin) and mevastatin (compactin) on the fusion of L6 myoblasts
Q72033816Synthesis of benzyl O-(3-O-methyl-β-d-galactopyranosyl)-(1 → 3)-2-acetamido-2-deoxy-α-d-galactopyranoside and benzyl O-(β-d-galactopyranosyl)-(1 → 3)-2-acetamido-2-deoxy-6-O-methyl-α-d-galactopyranoside as specific acceptors for sialyltransferases
Q33804560Synthesis of oligosaccharides by bacterial enzymes
Q35574792Synthesis of sialoglycopolypeptide for potentially blocking influenza virus infection using a rat alpha2,6-sialyltransferase expressed in BmNPV bacmid-injected silkworm larvae
Q37568588Systems-based candidate genes for human response to influenza infection
Q48566892Targeting of active sialyltransferase to the plant Golgi apparatus
Q40493888Targeting of proteins to the Golgi apparatus
Q34974092Terminal glycosylation in cystic fibrosis (CF): a review emphasizing the airway epithelial cell
Q36531267The 17-residue transmembrane domain of beta-galactoside alpha 2,6-sialyltransferase is sufficient for Golgi retention
Q24682809The B cell antigen CD75 is a cell surface sialytransferase
Q33782199The E1 glycoprotein of an avian coronavirus is targeted to the cis Golgi complex
Q24643944The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase
Q37987919The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond
Q55480200The expression of CMP-NeuAc: Gal beta 1,4GlcNAc alpha 2,6 sialyltransferase [EC 2.4.99.1] and glycoproteins bearing alpha 2,6-linked sialic acids in human brain tumours.
Q35934419The membrane spanning domain of beta-1,4-galactosyltransferase specifies trans Golgi localization
Q64053597The regulatory ZFAS1/miR-150/ST6GAL1 crosstalk modulates sialylation of EGFR via PI3K/Akt pathway in T-cell acute lymphoblastic leukemia
Q41995009The role of a cathepsin D-like activity in the release of Gal beta 1-4GlcNAc alpha 2-6-sialyltransferase from rat liver Golgi membranes during the acute-phase response
Q74552056The role of glycoproteins in neural development function, and disease
Q34292917The sialyl-alpha2,6-lactosaminyl-structure: biosynthesis and functional role
Q34329454The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity
Q39797061Transcriptional regulation of the human ST6GAL2 gene in cerebral cortex and neuronal cells
Q36127847Transcriptome response to heat stress in a chicken hepatocellular carcinoma cell line
Q35063963Treatment response in Kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin G
Q24678675cDNA cloning reveals the molecular structure of a sperm surface protein, PH-20, involved in sperm-egg adhesion and the wide distribution of its gene among mammals
Q28631479gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer
Q67848553n-butyrate reduces the expression of beta-galactoside alpha 2,6-sialyltransferase in Hep G2 cells