Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic-Industry Partnership.

scientific article published on 24 December 2017

Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic-Industry Partnership. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/ACSINFECDIS.7B00122
P932PMC publication ID5893282
P698PubMed publication ID29275629

P50authorRahul M. KohliQ55189769
P2093author name stringTrevor Selwood
Paul M Keller
Amy Quinn
Katherine L Widdowson
Jessica Schneck
Andrew J Pope
Charlie Y Mo
Matthew J Culyba
Zachary M Hostetler
Anthony J Jurewicz
Jeffrey M Kubiak
P2860cites workSOS response induces persistence to fluoroquinolones in Escherichia coliQ21144990
Inhibition of mutation and combating the evolution of antibiotic resistanceQ21146100
Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collectionQ22122301
Autodigestion of lexA and phage lambda repressorsQ24597460
Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesisQ24625342
Quinolone Resistance Reversion by Targeting the SOS Response.Q42264036
Identification of specific inhibitors of human RAD51 recombinase using high-throughput screeningQ42763386
Suramin is a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery.Q43633453
New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applicationsQ44001816
Intramolecular cleavage of LexA and phage lambda repressors: dependence of kinetics on repressor concentration, pH, temperature, and solventQ44913815
In vitro selection of preferred DNA pairing sequences by the Escherichia coli RecA protein.Q45933165
Lessons from 50 years of SOS DNA-damage-induced mutagenesis.Q46014624
RecA Inhibitors Potentiate Antibiotic Activity and Block Evolution of Antibiotic Resistance.Q50868599
University-industry partnership.Q53495128
Effect of recA inactivation on mutagenesis of Escherichia coli exposed to sublethal concentrations of antimicrobials.Q54372713
The Ecstasy and Agony of Assay Interference CompoundsQ60502259
Prospects for productivityQ80070266
Conformationally selective binding of nucleotide analogues to Escherichia coli RecA: a ligand-based analysis of the RecA ATP binding siteQ83052942
Partnering with the professorQ87422390
Directed molecular screening for RecA ATPase inhibitorsQ24684082
The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic–industrial partnershipQ26767471
A systematic review and critical assessment of incentive strategies for discovery and development of novel antibioticsQ26783545
Click chemistry in peptide-based drug designQ26853053
Crystal structure of LexA: a conformational switch for regulation of self-cleavageQ27634783
Structure of the LexA–DNA complex and implications for SOS box measurementQ27664039
Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesisQ27681412
SOS Repair Hypothesis: Phenomenology of an Inducible DNA Repair Which is Accompanied by MutagenesisQ28141658
Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leadsQ28477646
The SOS response controls integron recombination.Q29346620
Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particlesQ30145662
Inhibitors of RecA activity discovered by high-throughput screening: cell-permeable small molecules attenuate the SOS response in Escherichia coliQ30479751
A genetic screen for isolating "lariat" Peptide inhibitors of protein functionQ30921487
A comprehensive library of fluorescent transcriptional reporters for Escherichia coliQ33251466
SOS involvement in stress-inducible biofilm formationQ33625735
Novel Inhibitors of E. coli RecA ATPase ActivityQ33637395
How antibiotics kill bacteria: from targets to networksQ33958766
Emerging principles in protease-based drug discoveryQ34282102
The bacterial LexA transcriptional repressor.Q34813362
Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasisQ35126182
Targets for Combating the Evolution of Acquired Antibiotic ResistanceQ35754447
High-throughput screening for RecA inhibitors using a transcreener adenosine 5'-O-diphosphate assayQ36029187
A complementary pair of rapid molecular screening assays for RecA activitiesQ36091838
Controlling mutation: intervening in evolution as a therapeutic strategyQ36961674
SOS regulation of qnrB expressionQ37072051
Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapyQ37114251
Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating AntibioticsQ37166834
The SOS response promotes qnrB quinolone-resistance determinant expressionQ37304655
Drug discovery: new models for industry-academic partnershipsQ37320886
Reaction of LexA repressor with diisopropyl fluorophosphate. A test of the serine protease model.Q38339756
SOS response in bacteria: Inhibitory activity of lichen secondary metabolites against Escherichia coli RecA proteinQ38780295
Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistanceQ39197564
Specificity determinants for autoproteolysis of LexA, a key regulator of bacterial SOS mutagenesis.Q39867010
Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trialQ40962449
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectSOS responseQ143584
antivirulent agentQ25101109
P304page(s)349-359
P577publication date2018-01-08
P1433published inACS Infectious DiseasesQ24067932
P1476titleInhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic-Industry Partnership
P478volume4

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cites work (P2860)
Q60949764Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response
Q90571043Lytic gene expression in the temperate bacteriophage GIL01 is activated by a phage-encoded LexA homologue
Q90192897Multitarget Approaches against Multiresistant Superbugs
Q89782500Targeting the Class A Carbapenemase GES-5 via Virtual Screening

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