Effect of simvastatin on MMPs and TIMPs in human brain endothelial cells and experimental stroke

scientific article published on 5 December 2014

Effect of simvastatin on MMPs and TIMPs in human brain endothelial cells and experimental stroke is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12975-014-0381-7
P698PubMed publication ID25476155
P5875ResearchGate publication ID269185027

P50authorMichael HennericiQ103148821
P2093author name stringStephen Meairs
Peter Bugert
Marc Fatar
Björn Reuter
Saskia Grudzenski
Claus Rodemer
P2860cites workMultiple roles for MMPs and TIMPs in cerebral ischemiaQ36104645
Matrix metalloproteinases in cerebrovascular diseasesQ36222712
Statin therapy and outcome after ischemic stroke: systematic review and meta-analysis of observational studies and randomized trials.Q38071519
Temporal profile of matrix metalloproteinases and their inhibitors in a human endothelial cell culture model of cerebral ischemiaQ39132066
Blood-brain barrier-specific properties of a human adult brain endothelial cell lineQ40377619
Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability.Q43234063
Statin treatment and stroke outcome in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial.Q43278301
Statins inhibit secretion of metalloproteinases-1, -2, -3, and -9 from vascular smooth muscle cells and macrophagesQ44381124
Effects of statins on matrix metalloproteinases and their endogenous inhibitors in human endothelial cellsQ45774346
Statin use during ischemic stroke hospitalization is strongly associated with improved poststroke survival.Q48825219
Simvastatin could prevent increase of the serum MMP-9/TIMP-1 ratio in acute ischaemic strokeQ79447127
Markers of instability in high-risk carotid plaques are reduced by statinsQ80759664
P433issue2
P921main subjectsimvastatinQ670131
P304page(s)156-159
P577publication date2014-12-05
P1433published inTranslational stroke researchQ26842494
P1476titleEffect of simvastatin on MMPs and TIMPs in human brain endothelial cells and experimental stroke
P478volume6

Reverse relations

cites work (P2860)
Q50052994Association of SNPs in the TIMP-2 gene and large artery atherosclerotic stroke in southern Chinese Han population
Q47910464Blood-brain barrier dysfunction and recovery after ischemic stroke
Q89289786Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection
Q52147983Cyclooxygenase-2 Inhibition Provides Lasting Protection Following Germinal Matrix Hemorrhage in Premature Infant Rats.
Q38592449Factors controlling permeability of the blood-brain barrier
Q51007468Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats.
Q48165537Iptakalim protects against ischemic injury by improving neurovascular unit function in the mouse brain
Q40491247Long-acting statin for aneurysmal subarachnoid hemorrhage: A randomized, double-blind, placebo-controlled trial.
Q36244982Models and mechanisms of vascular dementia
Q39143724Molecular hydrogen: a therapeutic antioxidant and beyond
Q37576181Neuroprotective effect of hyperbaric oxygen therapy in a juvenile rat model of repetitive mild traumatic brain injury
Q37576186Paradigms and mechanisms of inhalational anesthetics mediated neuroprotection against cerebral ischemic stroke.
Q44836823Recent Advances in Stem Cell-Based Therapeutics for Stroke
Q48337519Regulated and Unregulated Clinical Trials of Stem Cell Therapies for Stroke
Q36512688Statin Therapy and the Development of Cerebral Amyloid Angiopathy--A Rodent in Vivo Approach
Q52583601The Role of IRE1 Signaling in Central Nervous System Diseases.
Q38969718The impact of cerebrovascular aging on vascular cognitive impairment and dementia.
Q42368544The production of high dose hydrogen gas by the AMS-H-01 for treatment of disease
Q36731242Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals.
Q28078744Update on Inflammatory Biomarkers and Treatments in Ischemic Stroke
Q36926500Ursolic acid reduces the metalloprotease/anti-metalloprotease imbalance in cerebral ischemia and reperfusion injury
Q38374295Vinpocetine Inhibits NF-κB-Dependent Inflammation in Acute Ischemic Stroke Patients.
Q30959630What's New in Traumatic Brain Injury: Update on Tracking, Monitoring and Treatment

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